Longitudinal associations between urinary biomarkers of phthalates and replacements with novel in vivo measures of placental health Article Swipe
Emma M. Rosen
,
Danielle R. Stevens
,
Erin E McNell
,
Mollie E. Wood
,
Stephanie M. Engel
,
Alexander P. Keil
,
Antonia M. Calafat
,
Julianne Cook Botelho
,
Elena Sinkovskaya
,
Ann Przybylska
,
George R. Saade
,
Alfred Abuhamad
,
Kelly K. Ferguson
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/humrep/deae152
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/humrep/deae152
STUDY QUESTION What is the longitudinal association between gestational phthalate exposure and in vivo placental outcomes? SUMMARY ANSWER Phthalates were adversely associated with placental microvasculature, stiffness, and presence of calcification, with different metabolites associated with different outcomes. WHAT IS KNOWN ALREADY Phthalate exposure is ubiquitous and implicated as a contributor to adverse pregnancy outcomes, possibly through impacts on the placenta. STUDY DESIGN, SIZE, DURATION A total of 303 women were recruited in early pregnancy and prospectively followed for up to eight visits across gestation in the Human Placenta and Phthalates study. PARTICIPANTS/MATERIALS, SETTING, METHODS At each visit, women provided urine samples and underwent placental ultrasounds. Urine was analyzed for 18 metabolites of phthalates and replacements. We took the geometric mean of repeated measurements to reflect pregnancy-averaged phthalate or replacement exposure for each participant (n = 303). Placental microvasculature, stiffness, and microcalcification presence were quantified from ultrasounds at each visit. Higher scores reflected worse placental function for all measures. Generalized linear mixed models were created to estimate the association between pregnancy-averaged exposure biomarker concentrations and repeated outcome measurements for microvasculature and stiffness. Gestational age at the time of calcification detection was modeled using Cox proportional hazards models. MAIN RESULTS AND THE ROLE OF CHANCE Monocarboxyisononyl phthalate and summed di(2-ethylhexyl) phthalate metabolites were associated with impaired microvasculature development, such that an interquartile range increase in concentration was associated with 0.11 standard deviation increase in the microvasculature ratio, indicating poorer vascularization (95% CI: 0.00, 0.22); 0.11 [95% CI: −0.01, 0.22], respectively. Monoethyl phthalate was associated with increased placental stiffness (0.09 [95% CI: −0.01, 0.19]) while summed di-iso-butyl phthalate metabolites and monobenzyl phthalate were associated with increased hazard of calcification detection (hazard ratios: 1.18 [95% CI: 0.98, 1.42]; 1.13 [95% CI: 0.96, 1.34]). LIMITATIONS, REASONS FOR CAUTION Outcomes used in this study are novel and further investigation is needed to provide clinical context and relevance. WIDER IMPLICATIONS OF THE FINDINGS We found evidence of associations between select phthalate biomarkers and various aspects of in vivo placental health, although we did not observe consistency across placental outcomes. These findings could illustrate heterogeneous effects of phthalate exposure on placental function. STUDY FUNDING/COMPETING INTEREST(S) This research was supported in part by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (ZIA ES103344), and NIEHS T32ES007018. The authors declare that they have no competing interests to disclose. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Use of trade names is for identification only and does not imply endorsement by the CDC, the Public Health Service, or the US Department of Health and Human Services. TRIAL REGISTRATION NUMBER N/A.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/humrep/deae152
- OA Status
- green
- Cited By
- 5
- References
- 71
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4400379550Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/humrep/deae152Digital Object Identifier
- Title
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Longitudinal associations between urinary biomarkers of phthalates and replacements with novel in vivo measures of placental healthWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-07-06Full publication date if available
- Authors
-
Emma M. Rosen, Danielle R. Stevens, Erin E McNell, Mollie E. Wood, Stephanie M. Engel, Alexander P. Keil, Antonia M. Calafat, Julianne Cook Botelho, Elena Sinkovskaya, Ann Przybylska, George R. Saade, Alfred Abuhamad, Kelly K. FergusonList of authors in order
- Landing page
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https://doi.org/10.1093/humrep/deae152Publisher landing page
- Open access
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/11373341Direct OA link when available
- Concepts
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Phthalate, Interquartile range, Pregnancy, Medicine, Urine, Gestation, Physiology, Obstetrics, Biomarker, Preeclampsia, Placenta, Fetus, Internal medicine, Biology, Chemistry, Genetics, Biochemistry, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 4, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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71Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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