Longitudinal Cognitive Changes in Genetic Frontotemporal Dementia Within the GENFI Cohort Article Swipe
Related Concepts
C9orf72
Frontotemporal dementia
Dementia
Cohort
Cognitive decline
Neuropsychology
Clinical Dementia Rating
Executive dysfunction
Disease
Frontotemporal lobar degeneration
Oncology
Psychology
Executive functions
Medicine
Cognition
Internal medicine
Psychiatry
Jackie M. Poos
,
Amy MacDougall
,
Esther van den Berg
,
Lize C. Jiskoot
,
Janne M. Papma
,
Emma L. van der Ende
,
Harro Seelaar
,
Lucy L. Russell
,
Georgia Peakman
,
Rhian S. Convery
,
Yolande A.L. Pijnenburg
,
Fermín Moreno
,
Raquel Sánchez‐Valle
,
Barbara Borroni
,
Robert Laforce
,
Marie-Claire Doré
,
Mario Masellis
,
Maria Carmela Tartaglia
,
Caroline Graff
,
Daniela Galimberti
,
James B. Rowe
,
Elizabeth Finger
,
Matthis Synofzik
,
Rik Vandenberghe
,
Alexandre de Mendonça
,
Pietro Tiraboschi
,
Isabel Santana
,
Simon Ducharme
,
Christopher Butler
,
Alexander Gerhard
,
Johannes Levin
,
Adrian Danek
,
Markus Otto
,
Isabelle Le Ber
,
Florence Pasquier
,
John C. van Swieten
,
Jonathan D. Rohrer
,
Martin N. Rossor
,
Nick C. Fox
,
Jason D. Warren
,
Ione Woollacott
,
Rachelle Shafei
,
Carolin Heller
,
Imogen J. Swift
,
Katrina Moore
,
Aitana Sogorb‐Esteve
,
Annabel Nelson
,
Arabella Bouzigues
,
Caroline Greaves
,
David L. Cash
,
Hanya Benotmane
,
Emily Todd
,
Henrik Zetterberg
,
Kiran Samra
,
Martina Bocchetta
,
Rita Guerreiro
,
José Brás
,
David L. Thomas
,
Jennifer Nicholas
,
Simon Mead
,
Lieke Meeter
,
Jessica Panman
,
Lucia Giannini
,
Rick van Minkelen
,
Myriam Barandiarán
,
Begoña Indakoetxea
,
Alazne Gabilondo
,
Mikel Tainta
,
María de Arriba
,
Ana Gorostidi
,
Miren Zulaica
,
Jorge Villanúa
,
Zigor Díaz
,
Ana Gorostidi
,
Marta Cañada
,
Patricia Alves
,
Sergi Borrego‐Écija
,
Jaume Olives
,
Albert Lladó
,
Mircea Balasa
,
Anna Antonell
,
Núria Bargalló
,
Enrico Premi
,
Maura Cosseddu
,
Stefano Gazzina
,
Alessandro Padovani
,
Alberto Benussi
,
Valentina Cantoni
,
Roberto Gasparotti
,
Silvana Archetti
,
Sandra E. Black
,
Sara Mitchell
,
Ekaterina Rogaeva
,
Morris Freedman
,
Ron Keren
,
David F. Tang‐Wai
,
Linn Öijerstedt
,
Christin Andersson
,
Vesna Jelić
,
Håkan Thonberg
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1212/wnl.0000000000200384
· OA: W4225128244
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1212/wnl.0000000000200384
· OA: W4225128244
We confirmed cognitive decline in the asymptomatic and prodromal stage of genetic FTD. Specifically, tests for attention, executive function, language, and memory showed clear differences between genetic groups and controls at baseline, but the speed of change over time differed depending on genetic group and disease stage. This confirms the value of neuropsychological assessment in tracking clinical onset and progression and could inform clinical trials in selecting sensitive end points for measuring treatment effects as well as characterizing the best time window for starting treatment.
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