Longitudinal examination of urine pH , specific gravity, protein, culture, and antimicrobial resistance profiles in healthy dogs
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· 2023
· Open Access
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· DOI: https://doi.org/10.1111/jvim.16860
Background Urine is routinely evaluated in dogs to assess health. Reference ranges for many urine properties are well established, but the scope of variation in these properties over time within healthy dogs is not well characterized. Objectives Longitudinally characterize urine properties in healthy dogs over 3 months. Animals Fourteen healthy client‐owned dogs. Methods In this prospective study, dogs were evaluated for health; then, mid‐stream free‐catch urine was collected from each dog at 12 timepoints over 3 months. Urine pH, urine specific gravity (USG), protein, cultures, and antimicrobial resistance profiles were assessed at each timepoint. Results Urine pH varied within and between dogs over time (Friedman's test: within P = .03; between P < .005). However, USG, protein, and bacterial diversity of urine were consistent within dogs over time, and only varied between dogs (Kruskal‐Wallis: between all P < .005). Antimicrobial resistant isolates were identified in 12 out of 14 dogs with 34 of 48 of the isolates demonstrating resistance to amoxicillin. Conclusions and Clinical Importance Urine pH should be assessed at multiple timepoints via pH meter before making clinical decisions. Mid‐stream free‐catch urine with high concentrations of bacteria (>10 5 CFU/mL) should not be considered the only indicator of urinary tract infection. Bacterial isolates from dogs in this study had widespread resistance to amoxicillin/oxacillin underscoring the need for antimicrobial stewardship.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/jvim.16860
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jvim.16860
- OA Status
- gold
- Cited By
- 6
- References
- 66
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4386530250Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/jvim.16860Digital Object Identifier
- Title
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Longitudinal examination of urine
pH , specific gravity, protein, culture, and antimicrobial resistance profiles in healthy dogsWork title - Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-09-08Full publication date if available
- Authors
-
Andrew McGlynn, Ryan Mrofchak, Rushil Madan, Christopher Madden, Mohammad Jawad Jahid, Dixie F. Mollenkopf, Thomas E. Wittum, Sheryl S. Justice, Adam J. Rudinsky, Jessica A. Hokamp, Vanessa L. HaleList of authors in order
- Landing page
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https://doi.org/10.1111/jvim.16860Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jvim.16860Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jvim.16860Direct OA link when available
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Urine, Medicine, Amoxicillin, Antimicrobial, Urinary system, Antibiotic resistance, Urinalysis, Urine specific gravity, Microbiology, Internal medicine, Antibiotics, Physiology, BiologyTop concepts (fields/topics) attached by OpenAlex
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6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 3, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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66Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.amoxicillin/oxacillin | 214 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| citation_normalized_percentile.value | 0.86878275 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |