Longitudinal genetically detectable minimal residual disease by fluorescence in situ hybridization confers a poor prognosis in myeloma Article Swipe
Jian Cui
,
Tengteng Yu
,
Rui Lv
,
Jiahui Liu
,
Huishou Fan
,
Wenqiang Yan
,
Jingyu Xu
,
Chenxing Du
,
Shuhui Deng
,
Weiwei Sui
,
Matthew Ho
,
Yan Xu
,
Kenneth C. Anderson
,
Xifeng Dong
,
Lugui Qiu
,
Gang An
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1177/17588359231221340
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1177/17588359231221340
Background: Deeper depth of response (DpR) after induction therapy, especially gain of negative minimal residual disease (MRD), has been linked to prolonged survival in multiple myeloma (MM). However, flow-MRD examination focuses on the numbers but not on the biological characteristics of residual plasma cells (PCs). Objectives: To explore whether the genetic features of residual tumor cells affect the survival time of patients with MM. Design: A retrospective cohort study. Methods: We investigated the clonality of cytogenetic abnormalities (CAs) of the residual PCs using interphase fluorescence in situ hybridization (iFISH) in the National Longitudinal Cohort of Hematological Diseases in China (NCT04645199). Here, a longitudinal cohort of 269 patients with patient-paired diagnostic and post-induction iFISH results was analyzed. Results: Persistent CAs after induction therapy were detected in about half of the patients (118/269, 43%), and patients with undetectable CAs showed significantly improved survival compared with those with genetically detectable MRD [median progression-free survival (mPFS): 59.7 versus 35.7 months, p < 0.001; median overall survival (mOS): 97.1 versus 68.8 months, p = 0.011]. In addition, different patterns of therapy-induced clonal evolution were observed by comparing the clonal structure of residual PCs with paired baseline samples. Patients who maintained at a high risk during follow-up had the worst survival (mPFS: 30.5 months; mOS: 54.4 months), while those who returned to lower risk or had iFISH− at both time points had the best survival (mPFS: 62.0 months, mOS: not reached). Conclusion: These findings highlighted the prognostic value of genetic testing in residual tumor cells, which may provide a deep understanding of clonal evolution and guide clinical therapeutic strategies.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/17588359231221340
- https://journals.sagepub.com/doi/pdf/10.1177/17588359231221340
- OA Status
- gold
- Cited By
- 1
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391053780
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- OpenAlex ID
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https://openalex.org/W4391053780Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/17588359231221340Digital Object Identifier
- Title
-
Longitudinal genetically detectable minimal residual disease by fluorescence in situ hybridization confers a poor prognosis in myelomaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-01-01Full publication date if available
- Authors
-
Jian Cui, Tengteng Yu, Rui Lv, Jiahui Liu, Huishou Fan, Wenqiang Yan, Jingyu Xu, Chenxing Du, Shuhui Deng, Weiwei Sui, Matthew Ho, Yan Xu, Kenneth C. Anderson, Xifeng Dong, Lugui Qiu, Gang AnList of authors in order
- Landing page
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https://doi.org/10.1177/17588359231221340Publisher landing page
- PDF URL
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https://journals.sagepub.com/doi/pdf/10.1177/17588359231221340Direct link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
- OA URL
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https://journals.sagepub.com/doi/pdf/10.1177/17588359231221340Direct OA link when available
- Concepts
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Minimal residual disease, Medicine, Fluorescence in situ hybridization, Internal medicine, Cohort, Oncology, Multiple myeloma, Retrospective cohort study, Stage (stratigraphy), Gastroenterology, Survival analysis, Pathology, Genetics, Bone marrow, Biology, Gene, Paleontology, ChromosomeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
- References (count)
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33Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W3186399416, https://openalex.org/W3185171385, https://openalex.org/W3180549397, https://openalex.org/W3045223998, https://openalex.org/W2978799592, https://openalex.org/W2979296387, https://openalex.org/W4385723906, https://openalex.org/W4211129719, https://openalex.org/W2897472196, https://openalex.org/W2990816134, https://openalex.org/W3164261129, https://openalex.org/W2044799988, https://openalex.org/W2486629951, https://openalex.org/W2340686730, https://openalex.org/W2028286166, https://openalex.org/W4296713147, https://openalex.org/W4226154968, https://openalex.org/W2128192762, https://openalex.org/W2787046878, https://openalex.org/W2132838873, https://openalex.org/W2115385885, https://openalex.org/W3133251387, https://openalex.org/W1907306325, https://openalex.org/W2613977256, https://openalex.org/W4321611606, https://openalex.org/W2096999034, https://openalex.org/W2493385115, https://openalex.org/W2072546530, https://openalex.org/W2294916717, https://openalex.org/W2025013606, https://openalex.org/W2342466412, https://openalex.org/W2807892756, https://openalex.org/W4386695329 |
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| abstract_inverted_index.(mPFS): | 151 |
| abstract_inverted_index.0.011]. | 169 |
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