Longitudinal SARS-CoV-2 Testing among the Unvaccinated Is Punctuated by Intermittent Positivity and Variable Rates of Increasing Cycle Threshold Values Article Swipe
Shawn E. Hawken
,
Subhashini A. Sellers
,
Jason R. Smedberg
,
Jeremy D. Ward
,
Avian Elliott
,
Herbert C. Whinna
,
William A. Fischer
,
Melissa B. Miller
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1128/spectrum.02715-21
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1128/spectrum.02715-21
We describe the duration of positivity and the COVID-19 treatment and outcome characteristics of an unvaccinated population of patients with prolonged SARS-CoV-2 positivity. This investigation serves to highlight challenges in using C T values to guide clinical decisions among unvaccinated individuals.
Related Topics
Concepts
Medicine
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Coronavirus disease 2019 (COVID-19)
Longitudinal study
Internal medicine
Pandemic
Retrospective cohort study
Outbreak
Coronavirus
Disease
Pathology
Infectious disease (medical specialty)
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/spectrum.02715-21
- OA Status
- gold
- Cited By
- 3
- References
- 14
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4221029071
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4221029071Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1128/spectrum.02715-21Digital Object Identifier
- Title
-
Longitudinal SARS-CoV-2 Testing among the Unvaccinated Is Punctuated by Intermittent Positivity and Variable Rates of Increasing Cycle Threshold ValuesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-03-22Full publication date if available
- Authors
-
Shawn E. Hawken, Subhashini A. Sellers, Jason R. Smedberg, Jeremy D. Ward, Avian Elliott, Herbert C. Whinna, William A. Fischer, Melissa B. MillerList of authors in order
- Landing page
-
https://doi.org/10.1128/spectrum.02715-21Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1128/spectrum.02715-21Direct OA link when available
- Concepts
-
Medicine, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Coronavirus disease 2019 (COVID-19), Longitudinal study, Internal medicine, Pandemic, Retrospective cohort study, Outbreak, Coronavirus, Disease, Pathology, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
14Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4221029071 |
|---|---|
| doi | https://doi.org/10.1128/spectrum.02715-21 |
| ids.doi | https://doi.org/10.1128/spectrum.02715-21 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/35315712 |
| ids.openalex | https://openalex.org/W4221029071 |
| fwci | 0.37554539 |
| mesh[0].qualifier_ui | Q000175 |
| mesh[0].descriptor_ui | D000086382 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | diagnosis |
| mesh[0].descriptor_name | COVID-19 |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000086742 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | COVID-19 Testing |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D006801 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Humans |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D012313 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | RNA |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D000086402 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | SARS-CoV-2 |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D000093485 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | COVID-19 Drug Treatment |
| mesh[6].qualifier_ui | Q000175 |
| mesh[6].descriptor_ui | D000086382 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | diagnosis |
| mesh[6].descriptor_name | COVID-19 |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D000086742 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | COVID-19 Testing |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006801 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Humans |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D012313 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | RNA |
| mesh[10].qualifier_ui | Q000235 |
| mesh[10].descriptor_ui | D000086402 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | genetics |
| mesh[10].descriptor_name | SARS-CoV-2 |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D000093485 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | COVID-19 Drug Treatment |
| type | article |
| title | Longitudinal SARS-CoV-2 Testing among the Unvaccinated Is Punctuated by Intermittent Positivity and Variable Rates of Increasing Cycle Threshold Values |
| biblio.issue | 2 |
| biblio.volume | 10 |
| biblio.last_page | e0271521 |
| biblio.first_page | e0271521 |
| topics[0].id | https://openalex.org/T11754 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2725 |
| topics[0].subfield.display_name | Infectious Diseases |
| topics[0].display_name | SARS-CoV-2 detection and testing |
| topics[1].id | https://openalex.org/T10041 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9994999766349792 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2725 |
| topics[1].subfield.display_name | Infectious Diseases |
| topics[1].display_name | COVID-19 Clinical Research Studies |
| topics[2].id | https://openalex.org/T10118 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9988999962806702 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2725 |
| topics[2].subfield.display_name | Infectious Diseases |
| topics[2].display_name | SARS-CoV-2 and COVID-19 Research |
| is_xpac | False |
| apc_list.value | 2500 |
| apc_list.currency | USD |
| apc_list.value_usd | 2500 |
| apc_paid.value | 2500 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2500 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.680185079574585 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C3007834351 |
| concepts[1].level | 5 |
| concepts[1].score | 0.5665425062179565 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q82069695 |
| concepts[1].display_name | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| concepts[2].id | https://openalex.org/C3008058167 |
| concepts[2].level | 4 |
| concepts[2].score | 0.5626381635665894 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q84263196 |
| concepts[2].display_name | Coronavirus disease 2019 (COVID-19) |
| concepts[3].id | https://openalex.org/C2777895361 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5109614133834839 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1758614 |
| concepts[3].display_name | Longitudinal study |
| concepts[4].id | https://openalex.org/C126322002 |
| concepts[4].level | 1 |
| concepts[4].score | 0.48401591181755066 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[4].display_name | Internal medicine |
| concepts[5].id | https://openalex.org/C89623803 |
| concepts[5].level | 5 |
| concepts[5].score | 0.4806143641471863 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q12184 |
| concepts[5].display_name | Pandemic |
| concepts[6].id | https://openalex.org/C167135981 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4769531488418579 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2146302 |
| concepts[6].display_name | Retrospective cohort study |
| concepts[7].id | https://openalex.org/C116675565 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4390179514884949 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q3241045 |
| concepts[7].display_name | Outbreak |
| concepts[8].id | https://openalex.org/C2777648638 |
| concepts[8].level | 5 |
| concepts[8].score | 0.41119837760925293 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q57751738 |
| concepts[8].display_name | Coronavirus |
| concepts[9].id | https://openalex.org/C2779134260 |
| concepts[9].level | 2 |
| concepts[9].score | 0.31897759437561035 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[9].display_name | Disease |
| concepts[10].id | https://openalex.org/C142724271 |
| concepts[10].level | 1 |
| concepts[10].score | 0.19781631231307983 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[10].display_name | Pathology |
| concepts[11].id | https://openalex.org/C524204448 |
| concepts[11].level | 3 |
| concepts[11].score | 0.14819976687431335 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q788926 |
| concepts[11].display_name | Infectious disease (medical specialty) |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.680185079574585 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2 |
| keywords[1].score | 0.5665425062179565 |
| keywords[1].display_name | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| keywords[2].id | https://openalex.org/keywords/coronavirus-disease-2019 |
| keywords[2].score | 0.5626381635665894 |
| keywords[2].display_name | Coronavirus disease 2019 (COVID-19) |
| keywords[3].id | https://openalex.org/keywords/longitudinal-study |
| keywords[3].score | 0.5109614133834839 |
| keywords[3].display_name | Longitudinal study |
| keywords[4].id | https://openalex.org/keywords/internal-medicine |
| keywords[4].score | 0.48401591181755066 |
| keywords[4].display_name | Internal medicine |
| keywords[5].id | https://openalex.org/keywords/pandemic |
| keywords[5].score | 0.4806143641471863 |
| keywords[5].display_name | Pandemic |
| keywords[6].id | https://openalex.org/keywords/retrospective-cohort-study |
| keywords[6].score | 0.4769531488418579 |
| keywords[6].display_name | Retrospective cohort study |
| keywords[7].id | https://openalex.org/keywords/outbreak |
| keywords[7].score | 0.4390179514884949 |
| keywords[7].display_name | Outbreak |
| keywords[8].id | https://openalex.org/keywords/coronavirus |
| keywords[8].score | 0.41119837760925293 |
| keywords[8].display_name | Coronavirus |
| keywords[9].id | https://openalex.org/keywords/disease |
| keywords[9].score | 0.31897759437561035 |
| keywords[9].display_name | Disease |
| keywords[10].id | https://openalex.org/keywords/pathology |
| keywords[10].score | 0.19781631231307983 |
| keywords[10].display_name | Pathology |
| keywords[11].id | https://openalex.org/keywords/infectious-disease |
| keywords[11].score | 0.14819976687431335 |
| keywords[11].display_name | Infectious disease (medical specialty) |
| language | en |
| locations[0].id | doi:10.1128/spectrum.02715-21 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2764766708 |
| locations[0].source.issn | 2165-0497 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2165-0497 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Microbiology Spectrum |
| locations[0].source.host_organization | https://openalex.org/P4310320263 |
| locations[0].source.host_organization_name | American Society for Microbiology |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320263 |
| locations[0].source.host_organization_lineage_names | American Society for Microbiology |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Microbiology Spectrum |
| locations[0].landing_page_url | https://doi.org/10.1128/spectrum.02715-21 |
| locations[1].id | pmid:35315712 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Microbiology spectrum |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/35315712 |
| locations[2].id | pmh:oai:doaj.org/article:c0f81158470f4584b62e30a61142ea12 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Microbiology Spectrum, Vol 10, Iss 2 (2022) |
| locations[2].landing_page_url | https://doaj.org/article/c0f81158470f4584b62e30a61142ea12 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:9045176 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Microbiol Spectr |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9045176 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5081196210 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-3274-9230 |
| authorships[0].author.display_name | Shawn E. Hawken |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I1333535994 |
| authorships[0].affiliations[0].raw_affiliation_string | Clinical Microbiology Laboratory, McLendon Clinical Laboratories, UNC Medical Center, Chapel Hill, North Carolina, USA |
| authorships[0].institutions[0].id | https://openalex.org/I1333535994 |
| authorships[0].institutions[0].ror | https://ror.org/00qz24g20 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I1333535994 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | University of North Carolina Health Care |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Shawn E. Hawken |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Clinical Microbiology Laboratory, McLendon Clinical Laboratories, UNC Medical Center, Chapel Hill, North Carolina, USA |
| authorships[1].author.id | https://openalex.org/A5054823570 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-2852-4634 |
| authorships[1].author.display_name | Subhashini A. Sellers |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Medicine, Division of Pulmonary Diseases and Critical Care Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA |
| authorships[1].institutions[0].id | https://openalex.org/I114027177 |
| authorships[1].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Subhashini A. Sellers |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Medicine, Division of Pulmonary Diseases and Critical Care Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA |
| authorships[2].author.id | https://openalex.org/A5019855666 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Jason R. Smedberg |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1333535994 |
| authorships[2].affiliations[0].raw_affiliation_string | Clinical Microbiology Laboratory, McLendon Clinical Laboratories, UNC Medical Center, Chapel Hill, North Carolina, USA |
| authorships[2].institutions[0].id | https://openalex.org/I1333535994 |
| authorships[2].institutions[0].ror | https://ror.org/00qz24g20 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I1333535994 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | University of North Carolina Health Care |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Jason R. Smedberg |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Clinical Microbiology Laboratory, McLendon Clinical Laboratories, UNC Medical Center, Chapel Hill, North Carolina, USA |
| authorships[3].author.id | https://openalex.org/A5061283252 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-0410-8559 |
| authorships[3].author.display_name | Jeremy D. Ward |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA |
| authorships[3].institutions[0].id | https://openalex.org/I114027177 |
| authorships[3].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jeremy D. Ward |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA |
| authorships[4].author.id | https://openalex.org/A5007374784 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Avian Elliott |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1333535994 |
| authorships[4].affiliations[0].raw_affiliation_string | Clinical Microbiology Laboratory, McLendon Clinical Laboratories, UNC Medical Center, Chapel Hill, North Carolina, USA |
| authorships[4].institutions[0].id | https://openalex.org/I1333535994 |
| authorships[4].institutions[0].ror | https://ror.org/00qz24g20 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I1333535994 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | University of North Carolina Health Care |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Avian M. Elliott |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Clinical Microbiology Laboratory, McLendon Clinical Laboratories, UNC Medical Center, Chapel Hill, North Carolina, USA |
| authorships[5].author.id | https://openalex.org/A5055212805 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Herbert C. Whinna |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA |
| authorships[5].institutions[0].id | https://openalex.org/I114027177 |
| authorships[5].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Herbert C. Whinna |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA |
| authorships[6].author.id | https://openalex.org/A5002687453 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-4900-098X |
| authorships[6].author.display_name | William A. Fischer |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Medicine, Division of Pulmonary Diseases and Critical Care Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA |
| authorships[6].institutions[0].id | https://openalex.org/I114027177 |
| authorships[6].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | William A. Fischer |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Medicine, Division of Pulmonary Diseases and Critical Care Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA |
| authorships[7].author.id | https://openalex.org/A5041028634 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-0296-3535 |
| authorships[7].author.display_name | Melissa B. Miller |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I1333535994 |
| authorships[7].affiliations[0].raw_affiliation_string | Clinical Microbiology Laboratory, McLendon Clinical Laboratories, UNC Medical Center, Chapel Hill, North Carolina, USA |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I114027177 |
| authorships[7].affiliations[1].raw_affiliation_string | Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA |
| authorships[7].institutions[0].id | https://openalex.org/I1333535994 |
| authorships[7].institutions[0].ror | https://ror.org/00qz24g20 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I1333535994 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | University of North Carolina Health Care |
| authorships[7].institutions[1].id | https://openalex.org/I114027177 |
| authorships[7].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[7].institutions[1].country_code | US |
| authorships[7].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Melissa B. Miller |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Clinical Microbiology Laboratory, McLendon Clinical Laboratories, UNC Medical Center, Chapel Hill, North Carolina, USA, Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1128/spectrum.02715-21 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Longitudinal SARS-CoV-2 Testing among the Unvaccinated Is Punctuated by Intermittent Positivity and Variable Rates of Increasing Cycle Threshold Values |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-23T05:10:03.516525 |
| primary_topic.id | https://openalex.org/T11754 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2725 |
| primary_topic.subfield.display_name | Infectious Diseases |
| primary_topic.display_name | SARS-CoV-2 detection and testing |
| related_works | https://openalex.org/W2373635223, https://openalex.org/W2412355096, https://openalex.org/W3201614372, https://openalex.org/W3048636488, https://openalex.org/W3028088776, https://openalex.org/W3166731206, https://openalex.org/W3002812395, https://openalex.org/W3047950519, https://openalex.org/W3023213585, https://openalex.org/W3046089062 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2022 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1128/spectrum.02715-21 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764766708 |
| best_oa_location.source.issn | 2165-0497 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2165-0497 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Microbiology Spectrum |
| best_oa_location.source.host_organization | https://openalex.org/P4310320263 |
| best_oa_location.source.host_organization_name | American Society for Microbiology |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320263 |
| best_oa_location.source.host_organization_lineage_names | American Society for Microbiology |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Microbiology Spectrum |
| best_oa_location.landing_page_url | https://doi.org/10.1128/spectrum.02715-21 |
| primary_location.id | doi:10.1128/spectrum.02715-21 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2764766708 |
| primary_location.source.issn | 2165-0497 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2165-0497 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Microbiology Spectrum |
| primary_location.source.host_organization | https://openalex.org/P4310320263 |
| primary_location.source.host_organization_name | American Society for Microbiology |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320263 |
| primary_location.source.host_organization_lineage_names | American Society for Microbiology |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Microbiology Spectrum |
| primary_location.landing_page_url | https://doi.org/10.1128/spectrum.02715-21 |
| publication_date | 2022-03-22 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W3015696390, https://openalex.org/W3104457017, https://openalex.org/W3094870207, https://openalex.org/W3110332236, https://openalex.org/W3016173697, https://openalex.org/W3094119287, https://openalex.org/W3016671044, https://openalex.org/W3055651983, https://openalex.org/W3213619622, https://openalex.org/W3144105768, https://openalex.org/W3160891790, https://openalex.org/W3045700899, https://openalex.org/W3132370527, https://openalex.org/W2582743722 |
| referenced_works_count | 14 |
| abstract_inverted_index.C | 31 |
| abstract_inverted_index.T | 32 |
| abstract_inverted_index.We | 0 |
| abstract_inverted_index.an | 14 |
| abstract_inverted_index.in | 29 |
| abstract_inverted_index.of | 4, 13, 17 |
| abstract_inverted_index.to | 26, 34 |
| abstract_inverted_index.and | 6, 10 |
| abstract_inverted_index.the | 2, 7 |
| abstract_inverted_index.This | 23 |
| abstract_inverted_index.with | 19 |
| abstract_inverted_index.among | 38 |
| abstract_inverted_index.guide | 35 |
| abstract_inverted_index.using | 30 |
| abstract_inverted_index.serves | 25 |
| abstract_inverted_index.values | 33 |
| abstract_inverted_index.outcome | 11 |
| abstract_inverted_index.COVID-19 | 8 |
| abstract_inverted_index.clinical | 36 |
| abstract_inverted_index.describe | 1 |
| abstract_inverted_index.duration | 3 |
| abstract_inverted_index.patients | 18 |
| abstract_inverted_index.decisions | 37 |
| abstract_inverted_index.highlight | 27 |
| abstract_inverted_index.prolonged | 20 |
| abstract_inverted_index.treatment | 9 |
| abstract_inverted_index.SARS-CoV-2 | 21 |
| abstract_inverted_index.challenges | 28 |
| abstract_inverted_index.population | 16 |
| abstract_inverted_index.positivity | 5 |
| abstract_inverted_index.positivity. | 22 |
| abstract_inverted_index.individuals. | 40 |
| abstract_inverted_index.unvaccinated | 15, 39 |
| abstract_inverted_index.investigation | 24 |
| abstract_inverted_index.characteristics | 12 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5041028634 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I114027177, https://openalex.org/I1333535994 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8700000047683716 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.55579272 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |