Long‐term demyelination and aging‐associated changes in mice corpus callosum; evidence for the role of accelerated aging in remyelination failure in a mouse model of multiple sclerosis Article Swipe
Elham Parandavar
,
Mahshid Shafizadeh
,
Shahin Ahmadian
,
Mohammad Javan
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/acel.14211
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/acel.14211
Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disorder affecting the central nervous system. Evidence suggests that age‐related neurodegeneration contributes to disability progression during the chronic stages of MS. Aging is characterized by decreased regeneration potential and impaired myelin repair in the brain. It is hypothesized that accelerated cellular aging contributes to the functional decline associated with neurodegenerative diseases. We assessed the impact of aging on myelin content in the corpus callosum (CC) and compared aging with the long‐term demyelination (LTD) consequents induced by 12 weeks of feeding with a cuprizone (CPZ) diet. Initially, evaluating myelin content in 2‐, 6‐, and 18‐month‐old mice revealed a reduction in myelin content, particularly at 18 months. Myelin thickness was decreased and the g‐ratio increased in aged mice. Although a lower myelin content and higher g‐ratio were observed in LTD model mice, compared to the normally aged mice, both aging and LTD exhibited relatively similar myelin ultrastructure. Our findings provide evidence that LTD exhibits the hallmarks of aging such as elevated expression of senescence‐associated genes, mitochondrial dysfunction, and high level of oxidative stress as observed following normal aging. We also investigated the senescence‐associated β‐galactosidase activity in O4 + late oligodendrocyte progenitor cells (OPCs). The senescent O4 + /β‐galactosidase + cells were elevated in the CPZ diet. Our data showed that the myelin degeneration in CC occurs throughout the lifespan, and LTD induced by CPZ accelerates the aging process which may explain the impairment of myelin repair in patients with progressive MS.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/acel.14211
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.14211
- OA Status
- gold
- Cited By
- 9
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399086609
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399086609Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/acel.14211Digital Object Identifier
- Title
-
Long‐term demyelination and aging‐associated changes in mice corpus callosum; evidence for the role of accelerated aging in remyelination failure in a mouse model of multiple sclerosisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-28Full publication date if available
- Authors
-
Elham Parandavar, Mahshid Shafizadeh, Shahin Ahmadian, Mohammad JavanList of authors in order
- Landing page
-
https://doi.org/10.1111/acel.14211Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.14211Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.14211Direct OA link when available
- Concepts
-
Remyelination, Myelin, Multiple sclerosis, Corpus callosum, Senescence, Biology, Oligodendrocyte, Neurodegeneration, Oxidative stress, Endocrinology, Internal medicine, Central nervous system, Neuroscience, Medicine, Immunology, Cell biology, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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54Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.demyelination | 81 |
| abstract_inverted_index.mitochondrial | 173 |
| abstract_inverted_index.oligodendrocyte | 197 |
| abstract_inverted_index.ultrastructure. | 154 |
| abstract_inverted_index.18‐month‐old | 103 |
| abstract_inverted_index.neurodegeneration | 20 |
| abstract_inverted_index.neurodegenerative | 59 |
| abstract_inverted_index.β‐galactosidase | 191 |
| abstract_inverted_index./β‐galactosidase | 205 |
| abstract_inverted_index.senescence‐associated | 171, 190 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5108038858, https://openalex.org/A5078662901 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| corresponding_institution_ids | https://openalex.org/I1516879, https://openalex.org/I23946033 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.41999998688697815 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.95471065 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |