Long‐Term Impact of Early Subclinical Leaflet Thrombosis After Transcatheter Aortic Valve Implantation Article Swipe
Juri Iwata
,
Kentaro Hayashida
,
Ryo Arita
,
T. Moriizumi
,
Akiyoshi Kajino
,
Shingo Sakata
,
Toshinobu Ryuzaki
,
Keitaro Shinada
,
Hikaru Tsuruta
,
Yoshitake Yamada
,
Jungo Kato
,
Tatsuo Takahashi
,
Masataka Yamazaki
,
Masahiro Jinzaki
,
Hideyuki Shimizu
,
Masaki Ieda
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/ccd.31435
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/ccd.31435
Background Hypoattenuated leaflet thickening (HALT) after transcatheter aortic valve implantation (TAVI) detected on multidetector computed tomography (MDCT) is considered leaflet thrombosis. However, its impact on long‐term clinical outcomes remains unclear. This study aimed to investigate the impact of early HALT detection after TAVI on long‐term clinical outcomes and structural valve deterioration beyond 6 years. Methods Of the 672 consecutive patients who underwent TAVI between 2013 and 2018, 448 were treated with either SAPIEN XT or SAPIEN 3 and underwent MDCT analysis within 30 days after TAVI. MDCT results and echocardiographic data were analyzed annually. Results HALT was detected in 68 (15.2%) of 448 eligible patients within 30 days after TAVI. No significant difference in effective orifice area was observed by echocardiography within 30 days after TAVI between the HALT and the non‐HALT groups in SAPIEN XT (HALT vs. non‐HALT: 1.62 ± 0.66 cm 2 vs. 1.72 ± 0.43 cm 2 ; p = 0.26) and in SAPIEN 3 (1.42 ± 0.35 cm 2 vs. 1.45 ± 0.34 cm 2 ; p = 0.63). No significant differences in all‐cause mortality (52.9% vs. 60.0%; hazard ratio (HR): 1.19; 95% confidence interval (CI): 0.83−1.70; p = 0.3), stroke incidence (5.9% vs. 7.1%; HR: 1.06; 95% CI: 0.08−13.7; p = 0.97), heart failure rehospitalization (10.3% vs. 15.0%; HR: 2.3; 95% CI: 0.89−5.99; p = 0.09), and structural valve deterioration (14.7% vs. 17.9%; HR: 0.89; 95% CI: 0.45−1.73; p = 0.73) were observed between the HALT and the non‐HALT groups during the median follow‐up of 1872 (interquartile range; 1203−2468) days. Conclusions HALT within 30 days was not associated with clinical outcomes or hemodynamic performance during long‐term follow‐up.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/ccd.31435
- OA Status
- green
- Cited By
- 1
- References
- 16
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407105456
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407105456Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/ccd.31435Digital Object Identifier
- Title
-
Long‐Term Impact of Early Subclinical Leaflet Thrombosis After Transcatheter Aortic Valve ImplantationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-02-03Full publication date if available
- Authors
-
Juri Iwata, Kentaro Hayashida, Ryo Arita, T. Moriizumi, Akiyoshi Kajino, Shingo Sakata, Toshinobu Ryuzaki, Keitaro Shinada, Hikaru Tsuruta, Yoshitake Yamada, Jungo Kato, Tatsuo Takahashi, Masataka Yamazaki, Masahiro Jinzaki, Hideyuki Shimizu, Masaki IedaList of authors in order
- Landing page
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https://doi.org/10.1002/ccd.31435Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/11962826Direct OA link when available
- Concepts
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Medicine, Cardiology, Internal medicine, Hazard ratio, Confidence interval, Subclinical infection, Aortic valve, Thrombosis, Stroke (engine), Incidence (geometry), Surgery, Physics, Optics, Mechanical engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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16Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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