Long‐Term Outcomes of Cryoballoon Pulmonary Vein Isolation Freeze Using a Modified ICE‐T Protocol With a Double 120 s Applications (ICE‐T 2 × 2) Article Swipe
Andrea Urbani
,
Stefano Bordignon
,
Shota Tohoku
,
David Schaack
,
Jun Hirokami
,
Alexandra Steyer
,
Lukas Urbanek
,
Joseph Antoine Kheir
,
Boris Schmidt
,
K. R. Julian Chun
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/jce.16746
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/jce.16746
Background Cryoballoon (CB) pulmonary vein isolation (PVI) is a well‐established treatment for symptomatic atrial fibrillation (AF). Most centers use application durations of 180 or 240 s. Since freezing‐related complications tend to occur later during the application, empirically shortening the duration may reduce procedural risks. A protocol using two consecutive 120‐s freezes was proposed. Here, we report its long‐term outcomes. Methods We performed a long‐term follow‐up comparison of patients with symptomatic AF undergoing PVI with second‐generation CB between 2019 and 2020. The conventional single 240‐s freeze protocol (CB240) was compared to a modified double 120‐s freeze protocol (CB120). Among 160 consecutive patients, 80 received CB120 and 80 CB240. A total of 140 patients (70/group) completed follow‐up. The primary endpoint was freedom from atrial tachyarrhythmia. Results Persistent AF was more common in the CB240 group (32%) than in the CB120 group (20%), ( p < 0.05). After a mean follow‐up of 948 ± 517 days, freedom from any atrial tachyarrhythmia at 1 year was 90% in the CB120 group and 82% in the CB240 group (log‐rank p = 0.122). The primary outcome was assessed after a single procedure, including antiarrhythmic drug (AAD) use. Conclusions The CB120 protocol appears noninferior to the standard CB240 protocol regarding long‐term efficacy, while offering a potentially more favorable safety profile. This protocol may represent a viable alternative for optimizing the balance between effectiveness and safety.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/jce.16746
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jce.16746
- OA Status
- bronze
- Cited By
- 1
- References
- 18
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411003989
All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W4411003989Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/jce.16746Digital Object Identifier
- Title
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Long‐Term Outcomes of Cryoballoon Pulmonary Vein Isolation Freeze Using a Modified ICE‐T Protocol With a Double 120 s Applications (ICE‐T 2 × 2)Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-06-03Full publication date if available
- Authors
-
Andrea Urbani, Stefano Bordignon, Shota Tohoku, David Schaack, Jun Hirokami, Alexandra Steyer, Lukas Urbanek, Joseph Antoine Kheir, Boris Schmidt, K. R. Julian ChunList of authors in order
- Landing page
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https://doi.org/10.1111/jce.16746Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jce.16746Direct link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jce.16746Direct OA link when available
- Concepts
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Medicine, Pulmonary vein, Atrial fibrillation, Clinical endpoint, Internal medicine, Protocol (science), Cardiology, Surgery, Anesthesia, Randomized controlled trial, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.balance | 224 |
| abstract_inverted_index.between | 77, 225 |
| abstract_inverted_index.centers | 18 |
| abstract_inverted_index.freedom | 120, 154 |
| abstract_inverted_index.freezes | 51 |
| abstract_inverted_index.outcome | 180 |
| abstract_inverted_index.primary | 117, 179 |
| abstract_inverted_index.safety. | 228 |
| abstract_inverted_index.(CB120). | 97 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.assessed | 182 |
| abstract_inverted_index.compared | 89 |
| abstract_inverted_index.duration | 40 |
| abstract_inverted_index.endpoint | 118 |
| abstract_inverted_index.modified | 92 |
| abstract_inverted_index.offering | 207 |
| abstract_inverted_index.patients | 68, 112 |
| abstract_inverted_index.profile. | 213 |
| abstract_inverted_index.protocol | 46, 86, 96, 195, 202, 215 |
| abstract_inverted_index.received | 103 |
| abstract_inverted_index.standard | 200 |
| abstract_inverted_index.completed | 114 |
| abstract_inverted_index.durations | 21 |
| abstract_inverted_index.efficacy, | 205 |
| abstract_inverted_index.favorable | 211 |
| abstract_inverted_index.including | 187 |
| abstract_inverted_index.isolation | 6 |
| abstract_inverted_index.outcomes. | 59 |
| abstract_inverted_index.patients, | 101 |
| abstract_inverted_index.performed | 62 |
| abstract_inverted_index.proposed. | 53 |
| abstract_inverted_index.pulmonary | 4 |
| abstract_inverted_index.regarding | 203 |
| abstract_inverted_index.represent | 217 |
| abstract_inverted_index.treatment | 11 |
| abstract_inverted_index.(70/group) | 113 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Persistent | 125 |
| abstract_inverted_index.comparison | 66 |
| abstract_inverted_index.optimizing | 222 |
| abstract_inverted_index.procedural | 43 |
| abstract_inverted_index.procedure, | 186 |
| abstract_inverted_index.shortening | 38 |
| abstract_inverted_index.undergoing | 72 |
| abstract_inverted_index.(log‐rank | 174 |
| abstract_inverted_index.Conclusions | 192 |
| abstract_inverted_index.Cryoballoon | 2 |
| abstract_inverted_index.alternative | 220 |
| abstract_inverted_index.application | 20 |
| abstract_inverted_index.consecutive | 49, 100 |
| abstract_inverted_index.empirically | 37 |
| abstract_inverted_index.follow‐up | 65, 148 |
| abstract_inverted_index.long‐term | 58, 64, 204 |
| abstract_inverted_index.noninferior | 197 |
| abstract_inverted_index.potentially | 209 |
| abstract_inverted_index.symptomatic | 13, 70 |
| abstract_inverted_index.application, | 36 |
| abstract_inverted_index.conventional | 82 |
| abstract_inverted_index.fibrillation | 15 |
| abstract_inverted_index.follow‐up. | 115 |
| abstract_inverted_index.complications | 29 |
| abstract_inverted_index.effectiveness | 226 |
| abstract_inverted_index.antiarrhythmic | 188 |
| abstract_inverted_index.tachyarrhythmia | 158 |
| abstract_inverted_index.tachyarrhythmia. | 123 |
| abstract_inverted_index.freezing‐related | 28 |
| abstract_inverted_index.well‐established | 10 |
| abstract_inverted_index.second‐generation | 75 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| citation_normalized_percentile.value | 0.87707554 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |