Loss of functional OPA 1 unbalances redox state: implications in dominant optic atrophy pathogenesis
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Related Concepts
Medicine
Pathogenesis
Atrophy
Redox
Pathology
Chemistry
Organic chemistry
Aurélie Millet
,
Ambre M. Bertholet
,
Marlène Daloyau
,
Pascal Reynier
,
Anne Galinier
,
Anne Devin
,
Bernd Wissinguer
,
Pascale Belenguer
,
Noélie Davezac
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1002/acn3.305
· OA: W2345282773
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1002/acn3.305
· OA: W2345282773
Our study suggests that the pro-oxidative state induced by OPA1 loss may contribute to DOA pathogenesis and that differences in antioxidant defenses can explain the variability in expressivity. Furthermore, antioxidants may be used as therapy as they could prevent or delay DOA symptoms in patients.
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