Loss of PDK1 Induces Meiotic Defects in Oocytes From Diabetic Mice Article Swipe
Juan Ge
,
Na Zhang
,
Shoubin Tang
,
Feifei Hu
,
Xiaojing Hou
,
Hongzheng Sun
,
Longsen Han
,
Qiang Wang
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fcell.2021.793389
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fcell.2021.793389
Maternal diabetes has been shown to impair oocyte quality; however, the underlying mechanisms remain unclear. Here, using a streptozotocin (STZ)-induced diabetic mouse model, we first detected and reduced expression of pyruvate dehydrogenase kinase 1 (PDK1) in diabetic oocytes, accompanying with the lowered phosphorylation of serine residue 232 on α subunit of the pyruvate dehydrogenase (PDH) complex (Ser232-PDHE1α). Importantly, forced expression of PDK1 not only elevated the phosphorylation level of Ser232-PDHE1α, but also partly prevented the spindle disorganization and chromosome misalignment in oocytes from diabetic mice, with no beneficial effects on metabolic dysfunction. Moreover, a phospho-mimetic S232D-PDHE1α mutant is also capable of ameliorating the maternal diabetes-associated meiotic defects. In sum, our data indicate that PDK1-controlled Ser232-PDHE1α phosphorylation pathway mediates the effects of diabetic environment on oocyte competence.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fcell.2021.793389
- https://www.frontiersin.org/articles/10.3389/fcell.2021.793389/pdf
- OA Status
- gold
- Cited By
- 6
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200028276
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4200028276Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fcell.2021.793389Digital Object Identifier
- Title
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Loss of PDK1 Induces Meiotic Defects in Oocytes From Diabetic MiceWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-12-20Full publication date if available
- Authors
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Juan Ge, Na Zhang, Shoubin Tang, Feifei Hu, Xiaojing Hou, Hongzheng Sun, Longsen Han, Qiang WangList of authors in order
- Landing page
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https://doi.org/10.3389/fcell.2021.793389Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fcell.2021.793389/pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fcell.2021.793389/pdfDirect OA link when available
- Concepts
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Oocyte, Phosphorylation, Pyruvate dehydrogenase complex, Serine, Streptozotocin, Cell biology, Endocrinology, Diabetes mellitus, Internal medicine, Biology, Chemistry, Medicine, Enzyme, Biochemistry, EmbryoTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2023: 2, 2022: 2Per-year citation counts (last 5 years)
- References (count)
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41Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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