Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma Article Swipe
Sara Basbous
,
Lydia Dif
,
Camille Dantzer
,
Sylvaine Di-Tommaso
,
Jean‐William Dupuy
,
Paulette Bioulac‐Sage
,
Anne‐Aurélie Raymond
,
Chantal Desdouets
,
Frédéric Saltel
,
Violaine Moreau
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41419-024-06420-3
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41419-024-06420-3
Entosis is a process that leads to the formation of cell-in-cell structures commonly found in cancers. Here, we identified entosis in hepatocellular carcinoma and the loss of Rnd3 (also known as RhoE) as an efficient inducer of this mechanism. We characterized the different stages and the molecular regulators of entosis induced after Rnd3 silencing. We demonstrated that this process depends on the RhoA/ROCK pathway, but not on E-cadherin. The proteomic profiling of entotic cells allowed us to identify LAMP1 as a protein upregulated by Rnd3 silencing and implicated not only in the degradation final stage of entosis, but also in the full mechanism. Moreover, we found a positive correlation between the presence of entotic cells and the metastatic potential of tumors in human patient samples. Altogether, these data suggest the involvement of entosis in liver tumor progression and highlight a new perspective for entosis analysis in medicine research as a novel therapeutic target.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41419-024-06420-3
- https://www.nature.com/articles/s41419-024-06420-3.pdf
- OA Status
- gold
- Cited By
- 10
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390841042
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4390841042Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41419-024-06420-3Digital Object Identifier
- Title
-
Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinomaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-13Full publication date if available
- Authors
-
Sara Basbous, Lydia Dif, Camille Dantzer, Sylvaine Di-Tommaso, Jean‐William Dupuy, Paulette Bioulac‐Sage, Anne‐Aurélie Raymond, Chantal Desdouets, Frédéric Saltel, Violaine MoreauList of authors in order
- Landing page
-
https://doi.org/10.1038/s41419-024-06420-3Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41419-024-06420-3.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41419-024-06420-3.pdfDirect OA link when available
- Concepts
-
RHOA, Gene silencing, Downregulation and upregulation, Cell biology, Cancer research, Biology, Hepatocellular carcinoma, Signal transduction, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 8, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
34Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4390841042 |
|---|---|
| doi | https://doi.org/10.1038/s41419-024-06420-3 |
| ids.doi | https://doi.org/10.1038/s41419-024-06420-3 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38218945 |
| ids.openalex | https://openalex.org/W4390841042 |
| fwci | 4.78684532 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000235 |
| mesh[1].descriptor_ui | D006528 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | genetics |
| mesh[1].descriptor_name | Carcinoma, Hepatocellular |
| mesh[2].qualifier_ui | Q000235 |
| mesh[2].descriptor_ui | D008113 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | genetics |
| mesh[2].descriptor_name | Liver Neoplasms |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D057691 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Entosis |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D040901 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Proteomics |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D014157 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Transcription Factors |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D020741 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | rho GTP-Binding Proteins |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D052118 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Lysosomal-Associated Membrane Protein 1 |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006801 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Humans |
| mesh[9].qualifier_ui | Q000235 |
| mesh[9].descriptor_ui | D006528 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | genetics |
| mesh[9].descriptor_name | Carcinoma, Hepatocellular |
| mesh[10].qualifier_ui | Q000235 |
| mesh[10].descriptor_ui | D008113 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | genetics |
| mesh[10].descriptor_name | Liver Neoplasms |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D057691 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Entosis |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D040901 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Proteomics |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D014157 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Transcription Factors |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D020741 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | rho GTP-Binding Proteins |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D052118 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Lysosomal-Associated Membrane Protein 1 |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D006801 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Humans |
| mesh[17].qualifier_ui | Q000235 |
| mesh[17].descriptor_ui | D006528 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | genetics |
| mesh[17].descriptor_name | Carcinoma, Hepatocellular |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D008113 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Liver Neoplasms |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D057691 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Entosis |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D040901 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Proteomics |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D014157 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Transcription Factors |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D020741 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | rho GTP-Binding Proteins |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D052118 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Lysosomal-Associated Membrane Protein 1 |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D006801 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Humans |
| mesh[25].qualifier_ui | Q000235 |
| mesh[25].descriptor_ui | D006528 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | genetics |
| mesh[25].descriptor_name | Carcinoma, Hepatocellular |
| mesh[26].qualifier_ui | Q000235 |
| mesh[26].descriptor_ui | D008113 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | genetics |
| mesh[26].descriptor_name | Liver Neoplasms |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D057691 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Entosis |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D040901 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Proteomics |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D014157 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Transcription Factors |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D020741 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | rho GTP-Binding Proteins |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D052118 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Lysosomal-Associated Membrane Protein 1 |
| type | article |
| title | Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma |
| biblio.issue | 1 |
| biblio.volume | 15 |
| biblio.last_page | 46 |
| biblio.first_page | 46 |
| grants[0].funder | https://openalex.org/F4320322361 |
| grants[0].award_id | |
| grants[0].funder_display_name | Fondation ARC pour la Recherche sur le Cancer |
| topics[0].id | https://openalex.org/T12672 |
| topics[0].field.id | https://openalex.org/fields/24 |
| topics[0].field.display_name | Immunology and Microbiology |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2403 |
| topics[0].subfield.display_name | Immunology |
| topics[0].display_name | Phagocytosis and Immune Regulation |
| topics[1].id | https://openalex.org/T12286 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9970999956130981 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2737 |
| topics[1].subfield.display_name | Physiology |
| topics[1].display_name | Erythrocyte Function and Pathophysiology |
| topics[2].id | https://openalex.org/T11313 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.9954000115394592 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2403 |
| topics[2].subfield.display_name | Immunology |
| topics[2].display_name | Immune cells in cancer |
| funders[0].id | https://openalex.org/F4320322361 |
| funders[0].ror | https://ror.org/0489qz649 |
| funders[0].display_name | Fondation ARC pour la Recherche sur le Cancer |
| is_xpac | False |
| apc_list.value | 2790 |
| apc_list.currency | GBP |
| apc_list.value_usd | 3422 |
| apc_paid.value | 2790 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 3422 |
| concepts[0].id | https://openalex.org/C2777093181 |
| concepts[0].level | 3 |
| concepts[0].score | 0.6866936683654785 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q15331450 |
| concepts[0].display_name | RHOA |
| concepts[1].id | https://openalex.org/C119056186 |
| concepts[1].level | 3 |
| concepts[1].score | 0.616649329662323 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1431332 |
| concepts[1].display_name | Gene silencing |
| concepts[2].id | https://openalex.org/C127561419 |
| concepts[2].level | 3 |
| concepts[2].score | 0.539384126663208 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q224527 |
| concepts[2].display_name | Downregulation and upregulation |
| concepts[3].id | https://openalex.org/C95444343 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5050426125526428 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[3].display_name | Cell biology |
| concepts[4].id | https://openalex.org/C502942594 |
| concepts[4].level | 1 |
| concepts[4].score | 0.48686331510543823 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[4].display_name | Cancer research |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.47969576716423035 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C2778019345 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4412401020526886 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1148337 |
| concepts[6].display_name | Hepatocellular carcinoma |
| concepts[7].id | https://openalex.org/C62478195 |
| concepts[7].level | 2 |
| concepts[7].score | 0.37000221014022827 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q828130 |
| concepts[7].display_name | Signal transduction |
| concepts[8].id | https://openalex.org/C104317684 |
| concepts[8].level | 2 |
| concepts[8].score | 0.11790600419044495 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[8].display_name | Gene |
| concepts[9].id | https://openalex.org/C55493867 |
| concepts[9].level | 1 |
| concepts[9].score | 0.0867849588394165 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[9].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/rhoa |
| keywords[0].score | 0.6866936683654785 |
| keywords[0].display_name | RHOA |
| keywords[1].id | https://openalex.org/keywords/gene-silencing |
| keywords[1].score | 0.616649329662323 |
| keywords[1].display_name | Gene silencing |
| keywords[2].id | https://openalex.org/keywords/downregulation-and-upregulation |
| keywords[2].score | 0.539384126663208 |
| keywords[2].display_name | Downregulation and upregulation |
| keywords[3].id | https://openalex.org/keywords/cell-biology |
| keywords[3].score | 0.5050426125526428 |
| keywords[3].display_name | Cell biology |
| keywords[4].id | https://openalex.org/keywords/cancer-research |
| keywords[4].score | 0.48686331510543823 |
| keywords[4].display_name | Cancer research |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.47969576716423035 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/hepatocellular-carcinoma |
| keywords[6].score | 0.4412401020526886 |
| keywords[6].display_name | Hepatocellular carcinoma |
| keywords[7].id | https://openalex.org/keywords/signal-transduction |
| keywords[7].score | 0.37000221014022827 |
| keywords[7].display_name | Signal transduction |
| keywords[8].id | https://openalex.org/keywords/gene |
| keywords[8].score | 0.11790600419044495 |
| keywords[8].display_name | Gene |
| keywords[9].id | https://openalex.org/keywords/biochemistry |
| keywords[9].score | 0.0867849588394165 |
| keywords[9].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.1038/s41419-024-06420-3 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S185208586 |
| locations[0].source.issn | 2041-4889 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2041-4889 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Cell Death and Disease |
| locations[0].source.host_organization | https://openalex.org/P4310319965 |
| locations[0].source.host_organization_name | Springer Nature |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319965 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.nature.com/articles/s41419-024-06420-3.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cell Death & Disease |
| locations[0].landing_page_url | https://doi.org/10.1038/s41419-024-06420-3 |
| locations[1].id | pmid:38218945 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cell death & disease |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38218945 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10787830 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10787830/pdf/41419_2024_Article_6420.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Cell Death Dis |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10787830 |
| locations[3].id | pmh:oai:doaj.org/article:00a999658bed44e197ffd3d054843606 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Cell Death and Disease, Vol 15, Iss 1, Pp 1-14 (2024) |
| locations[3].landing_page_url | https://doaj.org/article/00a999658bed44e197ffd3d054843606 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5058912031 |
| authorships[0].author.orcid | https://orcid.org/0009-0005-9717-6399 |
| authorships[0].author.display_name | Sara Basbous |
| authorships[0].countries | FR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I15057530, https://openalex.org/I154526488 |
| authorships[0].affiliations[0].raw_affiliation_string | University of Bordeaux, INSERM, BRIC, U1312, Bordeaux, France |
| authorships[0].institutions[0].id | https://openalex.org/I154526488 |
| authorships[0].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[0].institutions[0].country_code | FR |
| authorships[0].institutions[0].display_name | Inserm |
| authorships[0].institutions[1].id | https://openalex.org/I15057530 |
| authorships[0].institutions[1].ror | https://ror.org/057qpr032 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I15057530 |
| authorships[0].institutions[1].country_code | FR |
| authorships[0].institutions[1].display_name | Université de Bordeaux |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Sara Basbous |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | University of Bordeaux, INSERM, BRIC, U1312, Bordeaux, France |
| authorships[1].author.id | https://openalex.org/A5052763992 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-5922-141X |
| authorships[1].author.display_name | Lydia Dif |
| authorships[1].countries | FR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I15057530, https://openalex.org/I154526488 |
| authorships[1].affiliations[0].raw_affiliation_string | University of Bordeaux, INSERM, BRIC, U1312, Bordeaux, France |
| authorships[1].institutions[0].id | https://openalex.org/I154526488 |
| authorships[1].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[1].institutions[0].type | government |
| authorships[1].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[1].institutions[0].country_code | FR |
| authorships[1].institutions[0].display_name | Inserm |
| authorships[1].institutions[1].id | https://openalex.org/I15057530 |
| authorships[1].institutions[1].ror | https://ror.org/057qpr032 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I15057530 |
| authorships[1].institutions[1].country_code | FR |
| authorships[1].institutions[1].display_name | Université de Bordeaux |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Lydia Dif |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | University of Bordeaux, INSERM, BRIC, U1312, Bordeaux, France |
| authorships[2].author.id | https://openalex.org/A5092821602 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-3560-3712 |
| authorships[2].author.display_name | Camille Dantzer |
| authorships[2].countries | FR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I15057530, https://openalex.org/I154526488 |
| authorships[2].affiliations[0].raw_affiliation_string | University of Bordeaux, INSERM, BRIC, U1312, Bordeaux, France |
| authorships[2].institutions[0].id | https://openalex.org/I154526488 |
| authorships[2].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[2].institutions[0].type | government |
| authorships[2].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[2].institutions[0].country_code | FR |
| authorships[2].institutions[0].display_name | Inserm |
| authorships[2].institutions[1].id | https://openalex.org/I15057530 |
| authorships[2].institutions[1].ror | https://ror.org/057qpr032 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I15057530 |
| authorships[2].institutions[1].country_code | FR |
| authorships[2].institutions[1].display_name | Université de Bordeaux |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Camille Dantzer |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | University of Bordeaux, INSERM, BRIC, U1312, Bordeaux, France |
| authorships[3].author.id | https://openalex.org/A5062191903 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-4507-2844 |
| authorships[3].author.display_name | Sylvaine Di-Tommaso |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I3018323443 |
| authorships[3].affiliations[0].raw_affiliation_string | CHU de Bordeaux, 33076, Bordeaux, France |
| authorships[3].institutions[0].id | https://openalex.org/I3018323443 |
| authorships[3].institutions[0].ror | https://ror.org/01hq89f96 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I3018323443 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Centre Hospitalier Universitaire de Bordeaux |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Sylvaine Di-Tommaso |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | CHU de Bordeaux, 33076, Bordeaux, France |
| authorships[4].author.id | https://openalex.org/A5055278692 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-2448-4797 |
| authorships[4].author.display_name | Jean‐William Dupuy |
| authorships[4].countries | FR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I15057530 |
| authorships[4].affiliations[0].raw_affiliation_string | Oncoprot Platform, UMS005, TBMCore, University of Bordeaux, 33076, Bordeaux, France |
| authorships[4].institutions[0].id | https://openalex.org/I15057530 |
| authorships[4].institutions[0].ror | https://ror.org/057qpr032 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I15057530 |
| authorships[4].institutions[0].country_code | FR |
| authorships[4].institutions[0].display_name | Université de Bordeaux |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jean-William Dupuy |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Oncoprot Platform, UMS005, TBMCore, University of Bordeaux, 33076, Bordeaux, France |
| authorships[5].author.id | https://openalex.org/A5043787553 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-5952-0623 |
| authorships[5].author.display_name | Paulette Bioulac‐Sage |
| authorships[5].countries | FR |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I15057530, https://openalex.org/I154526488 |
| authorships[5].affiliations[0].raw_affiliation_string | University of Bordeaux, INSERM, BRIC, U1312, Bordeaux, France |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I3018323443 |
| authorships[5].affiliations[1].raw_affiliation_string | CHU de Bordeaux, 33076, Bordeaux, France |
| authorships[5].institutions[0].id | https://openalex.org/I3018323443 |
| authorships[5].institutions[0].ror | https://ror.org/01hq89f96 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I3018323443 |
| authorships[5].institutions[0].country_code | FR |
| authorships[5].institutions[0].display_name | Centre Hospitalier Universitaire de Bordeaux |
| authorships[5].institutions[1].id | https://openalex.org/I154526488 |
| authorships[5].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[5].institutions[1].type | government |
| authorships[5].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[5].institutions[1].country_code | FR |
| authorships[5].institutions[1].display_name | Inserm |
| authorships[5].institutions[2].id | https://openalex.org/I15057530 |
| authorships[5].institutions[2].ror | https://ror.org/057qpr032 |
| authorships[5].institutions[2].type | education |
| authorships[5].institutions[2].lineage | https://openalex.org/I15057530 |
| authorships[5].institutions[2].country_code | FR |
| authorships[5].institutions[2].display_name | Université de Bordeaux |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Paulette Bioulac-Sage |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | CHU de Bordeaux, 33076, Bordeaux, France, University of Bordeaux, INSERM, BRIC, U1312, Bordeaux, France |
| authorships[6].author.id | https://openalex.org/A5085057122 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-2697-9352 |
| authorships[6].author.display_name | Anne‐Aurélie Raymond |
| authorships[6].countries | FR |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I15057530, https://openalex.org/I154526488 |
| authorships[6].affiliations[0].raw_affiliation_string | University of Bordeaux, INSERM, BRIC, U1312, Bordeaux, France |
| authorships[6].institutions[0].id | https://openalex.org/I154526488 |
| authorships[6].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[6].institutions[0].type | government |
| authorships[6].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[6].institutions[0].country_code | FR |
| authorships[6].institutions[0].display_name | Inserm |
| authorships[6].institutions[1].id | https://openalex.org/I15057530 |
| authorships[6].institutions[1].ror | https://ror.org/057qpr032 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I15057530 |
| authorships[6].institutions[1].country_code | FR |
| authorships[6].institutions[1].display_name | Université de Bordeaux |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Anne-Aurélie Raymond |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | University of Bordeaux, INSERM, BRIC, U1312, Bordeaux, France |
| authorships[7].author.id | https://openalex.org/A5064701366 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-1955-8915 |
| authorships[7].author.display_name | Chantal Desdouets |
| authorships[7].countries | FR |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I39804081, https://openalex.org/I4210092322 |
| authorships[7].affiliations[0].raw_affiliation_string | Sorbonne University, INSERM, Centre de Recherche des Cordeliers (CRC), Paris, France |
| authorships[7].institutions[0].id | https://openalex.org/I4210092322 |
| authorships[7].institutions[0].ror | https://ror.org/00dmms154 |
| authorships[7].institutions[0].type | facility |
| authorships[7].institutions[0].lineage | https://openalex.org/I154526488, https://openalex.org/I204730241, https://openalex.org/I39804081, https://openalex.org/I4210092322 |
| authorships[7].institutions[0].country_code | FR |
| authorships[7].institutions[0].display_name | Centre de Recherche des Cordeliers |
| authorships[7].institutions[1].id | https://openalex.org/I154526488 |
| authorships[7].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[7].institutions[1].type | government |
| authorships[7].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[7].institutions[1].country_code | FR |
| authorships[7].institutions[1].display_name | Inserm |
| authorships[7].institutions[2].id | https://openalex.org/I39804081 |
| authorships[7].institutions[2].ror | https://ror.org/02en5vm52 |
| authorships[7].institutions[2].type | education |
| authorships[7].institutions[2].lineage | https://openalex.org/I39804081 |
| authorships[7].institutions[2].country_code | FR |
| authorships[7].institutions[2].display_name | Sorbonne Université |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Chantal Desdouets |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Sorbonne University, INSERM, Centre de Recherche des Cordeliers (CRC), Paris, France |
| authorships[8].author.id | https://openalex.org/A5008363807 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-0724-9680 |
| authorships[8].author.display_name | Frédéric Saltel |
| authorships[8].countries | FR |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I15057530 |
| authorships[8].affiliations[0].raw_affiliation_string | Oncoprot Platform, UMS005, TBMCore, University of Bordeaux, 33076, Bordeaux, France |
| authorships[8].institutions[0].id | https://openalex.org/I15057530 |
| authorships[8].institutions[0].ror | https://ror.org/057qpr032 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I15057530 |
| authorships[8].institutions[0].country_code | FR |
| authorships[8].institutions[0].display_name | Université de Bordeaux |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Frédéric Saltel |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Oncoprot Platform, UMS005, TBMCore, University of Bordeaux, 33076, Bordeaux, France |
| authorships[9].author.id | https://openalex.org/A5061596661 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-4513-7022 |
| authorships[9].author.display_name | Violaine Moreau |
| authorships[9].countries | FR |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I15057530, https://openalex.org/I154526488 |
| authorships[9].affiliations[0].raw_affiliation_string | University of Bordeaux, INSERM, BRIC, U1312, Bordeaux, France |
| authorships[9].institutions[0].id | https://openalex.org/I154526488 |
| authorships[9].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[9].institutions[0].type | government |
| authorships[9].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[9].institutions[0].country_code | FR |
| authorships[9].institutions[0].display_name | Inserm |
| authorships[9].institutions[1].id | https://openalex.org/I15057530 |
| authorships[9].institutions[1].ror | https://ror.org/057qpr032 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I15057530 |
| authorships[9].institutions[1].country_code | FR |
| authorships[9].institutions[1].display_name | Université de Bordeaux |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Violaine Moreau |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | University of Bordeaux, INSERM, BRIC, U1312, Bordeaux, France |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.nature.com/articles/s41419-024-06420-3.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12672 |
| primary_topic.field.id | https://openalex.org/fields/24 |
| primary_topic.field.display_name | Immunology and Microbiology |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2403 |
| primary_topic.subfield.display_name | Immunology |
| primary_topic.display_name | Phagocytosis and Immune Regulation |
| related_works | https://openalex.org/W2050549532, https://openalex.org/W2287829455, https://openalex.org/W2734942203, https://openalex.org/W4291736526, https://openalex.org/W4285097145, https://openalex.org/W2808743966, https://openalex.org/W2282093804, https://openalex.org/W3075108714, https://openalex.org/W2110133003, https://openalex.org/W2989328101 |
| cited_by_count | 10 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 8 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1038/s41419-024-06420-3 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S185208586 |
| best_oa_location.source.issn | 2041-4889 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2041-4889 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Cell Death and Disease |
| best_oa_location.source.host_organization | https://openalex.org/P4310319965 |
| best_oa_location.source.host_organization_name | Springer Nature |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319965 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.nature.com/articles/s41419-024-06420-3.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cell Death & Disease |
| best_oa_location.landing_page_url | https://doi.org/10.1038/s41419-024-06420-3 |
| primary_location.id | doi:10.1038/s41419-024-06420-3 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S185208586 |
| primary_location.source.issn | 2041-4889 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2041-4889 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Cell Death and Disease |
| primary_location.source.host_organization | https://openalex.org/P4310319965 |
| primary_location.source.host_organization_name | Springer Nature |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319965 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.nature.com/articles/s41419-024-06420-3.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cell Death & Disease |
| primary_location.landing_page_url | https://doi.org/10.1038/s41419-024-06420-3 |
| publication_date | 2024-01-13 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W1949061701, https://openalex.org/W3093810043, https://openalex.org/W2970099101, https://openalex.org/W2995619590, https://openalex.org/W3092866331, https://openalex.org/W3021856505, https://openalex.org/W3169407541, https://openalex.org/W3203524124, https://openalex.org/W2760186642, https://openalex.org/W2112497627, https://openalex.org/W2731058674, https://openalex.org/W3183761590, https://openalex.org/W2736017442, https://openalex.org/W2027468963, https://openalex.org/W2514488812, https://openalex.org/W2013113421, https://openalex.org/W1965137216, https://openalex.org/W4220921716, https://openalex.org/W2020189193, https://openalex.org/W2043133007, https://openalex.org/W2803241531, https://openalex.org/W2331432060, https://openalex.org/W2090570235, https://openalex.org/W2394787723, https://openalex.org/W3096796090, https://openalex.org/W2018418660, https://openalex.org/W2009486394, https://openalex.org/W2018917075, https://openalex.org/W2809504932, https://openalex.org/W2671187014, https://openalex.org/W4308834828, https://openalex.org/W2940095741, https://openalex.org/W4210812663, https://openalex.org/W3093250434 |
| referenced_works_count | 34 |
| abstract_inverted_index.a | 3, 81, 107, 140, 150 |
| abstract_inverted_index.We | 40, 55 |
| abstract_inverted_index.an | 34 |
| abstract_inverted_index.as | 31, 33, 80, 149 |
| abstract_inverted_index.by | 84 |
| abstract_inverted_index.in | 15, 21, 91, 100, 122, 134, 146 |
| abstract_inverted_index.is | 2 |
| abstract_inverted_index.of | 10, 27, 37, 49, 72, 96, 113, 120, 132 |
| abstract_inverted_index.on | 61, 67 |
| abstract_inverted_index.to | 7, 77 |
| abstract_inverted_index.us | 76 |
| abstract_inverted_index.we | 18, 105 |
| abstract_inverted_index.The | 69 |
| abstract_inverted_index.and | 24, 45, 87, 116, 138 |
| abstract_inverted_index.but | 65, 98 |
| abstract_inverted_index.for | 143 |
| abstract_inverted_index.new | 141 |
| abstract_inverted_index.not | 66, 89 |
| abstract_inverted_index.the | 8, 25, 42, 46, 62, 92, 101, 111, 117, 130 |
| abstract_inverted_index.Rnd3 | 28, 53, 85 |
| abstract_inverted_index.also | 99 |
| abstract_inverted_index.data | 128 |
| abstract_inverted_index.full | 102 |
| abstract_inverted_index.loss | 26 |
| abstract_inverted_index.only | 90 |
| abstract_inverted_index.that | 5, 57 |
| abstract_inverted_index.this | 38, 58 |
| abstract_inverted_index.(also | 29 |
| abstract_inverted_index.Here, | 17 |
| abstract_inverted_index.LAMP1 | 79 |
| abstract_inverted_index.RhoE) | 32 |
| abstract_inverted_index.after | 52 |
| abstract_inverted_index.cells | 74, 115 |
| abstract_inverted_index.final | 94 |
| abstract_inverted_index.found | 14, 106 |
| abstract_inverted_index.human | 123 |
| abstract_inverted_index.known | 30 |
| abstract_inverted_index.leads | 6 |
| abstract_inverted_index.liver | 135 |
| abstract_inverted_index.novel | 151 |
| abstract_inverted_index.stage | 95 |
| abstract_inverted_index.these | 127 |
| abstract_inverted_index.tumor | 136 |
| abstract_inverted_index.stages | 44 |
| abstract_inverted_index.tumors | 121 |
| abstract_inverted_index.Entosis | 1 |
| abstract_inverted_index.allowed | 75 |
| abstract_inverted_index.between | 110 |
| abstract_inverted_index.depends | 60 |
| abstract_inverted_index.entosis | 20, 50, 133, 144 |
| abstract_inverted_index.entotic | 73, 114 |
| abstract_inverted_index.induced | 51 |
| abstract_inverted_index.inducer | 36 |
| abstract_inverted_index.patient | 124 |
| abstract_inverted_index.process | 4, 59 |
| abstract_inverted_index.protein | 82 |
| abstract_inverted_index.suggest | 129 |
| abstract_inverted_index.target. | 153 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.analysis | 145 |
| abstract_inverted_index.cancers. | 16 |
| abstract_inverted_index.commonly | 13 |
| abstract_inverted_index.entosis, | 97 |
| abstract_inverted_index.identify | 78 |
| abstract_inverted_index.medicine | 147 |
| abstract_inverted_index.pathway, | 64 |
| abstract_inverted_index.positive | 108 |
| abstract_inverted_index.presence | 112 |
| abstract_inverted_index.research | 148 |
| abstract_inverted_index.samples. | 125 |
| abstract_inverted_index.Moreover, | 104 |
| abstract_inverted_index.RhoA/ROCK | 63 |
| abstract_inverted_index.carcinoma | 23 |
| abstract_inverted_index.different | 43 |
| abstract_inverted_index.efficient | 35 |
| abstract_inverted_index.formation | 9 |
| abstract_inverted_index.highlight | 139 |
| abstract_inverted_index.molecular | 47 |
| abstract_inverted_index.potential | 119 |
| abstract_inverted_index.profiling | 71 |
| abstract_inverted_index.proteomic | 70 |
| abstract_inverted_index.silencing | 86 |
| abstract_inverted_index.identified | 19 |
| abstract_inverted_index.implicated | 88 |
| abstract_inverted_index.mechanism. | 39, 103 |
| abstract_inverted_index.metastatic | 118 |
| abstract_inverted_index.regulators | 48 |
| abstract_inverted_index.silencing. | 54 |
| abstract_inverted_index.structures | 12 |
| abstract_inverted_index.Altogether, | 126 |
| abstract_inverted_index.E-cadherin. | 68 |
| abstract_inverted_index.correlation | 109 |
| abstract_inverted_index.degradation | 93 |
| abstract_inverted_index.involvement | 131 |
| abstract_inverted_index.perspective | 142 |
| abstract_inverted_index.progression | 137 |
| abstract_inverted_index.therapeutic | 152 |
| abstract_inverted_index.upregulated | 83 |
| abstract_inverted_index.cell-in-cell | 11 |
| abstract_inverted_index.demonstrated | 56 |
| abstract_inverted_index.characterized | 41 |
| abstract_inverted_index.hepatocellular | 22 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7200000286102295 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.922008 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |