Low-cost inkjet-printed nanostructured biosensor based on CRISPR/Cas12a system for pathogen detection Article Swipe
Angela Gilda Carota
,
Andrea Bonini
,
Massimo Urban
,
Noemi Poma
,
Federico Maria Vivaldi
,
Arianna Tavanti
,
Marianna Rossetti
,
Giulio Rosati
,
Arben Merkoçi
,
Fabio Di Francesco
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.bios.2024.116340
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.bios.2024.116340
The escalating global incidence of infectious diseases caused by pathogenic bacteria, especially in developing countries, emphasises the urgent need for rapid and portable pathogen detection devices. This study introduces a sensitive and specific electrochemical biosensing platform utilising cost-effective electrodes fabricated by inkjet-printing gold and silver nanoparticles on a plastic substrate. The biosensor exploits the CRISPR/Cas12a system for detecting a specific DNA sequence selected from the genome of the target pathogen. Upon detection, the trans-activity of Cas12a/gRNA is triggered, leading to the cleavage of rationally designed single-strand DNA reporters (linear and hairpin) labelled with methylene blue (ssDNA-MB) and bound to the electrode surface. In principle, this sensing mechanism can be adapted to any bacterium by choosing a proper guide RNA to target a specific sequence of its DNA. The biosensor's performance was assessed for two representative pathogens (a Gram-negative, Escherichia coli, and a Gram-positive, Staphylococcus aureus), and results obtained with inkjet-printed gold electrodes were compared with those obtained by commercial screen-printed gold electrodes. Our results show that the use of inkjet-printed nanostructured gold electrodes, which provide a large surface area, in combination with the use of hairpin reporters containing a poly-T loop can increase the sensitivity of the assay corresponding to a signal variation of 86%. DNA targets amplified from various clinically isolated bacteria, have been tested and demonstrate the potential of the proposed platform for point-of-need applications.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.bios.2024.116340
- https://ars.els-cdn.com/content/image/1-s2.0-S0956566324003452-ga1_lrg.jpg
- OA Status
- hybrid
- Cited By
- 14
- References
- 71
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4395448974
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4395448974Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.bios.2024.116340Digital Object Identifier
- Title
-
Low-cost inkjet-printed nanostructured biosensor based on CRISPR/Cas12a system for pathogen detectionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-25Full publication date if available
- Authors
-
Angela Gilda Carota, Andrea Bonini, Massimo Urban, Noemi Poma, Federico Maria Vivaldi, Arianna Tavanti, Marianna Rossetti, Giulio Rosati, Arben Merkoçi, Fabio Di FrancescoList of authors in order
- Landing page
-
https://doi.org/10.1016/j.bios.2024.116340Publisher landing page
- PDF URL
-
https://ars.els-cdn.com/content/image/1-s2.0-S0956566324003452-ga1_lrg.jpgDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://ars.els-cdn.com/content/image/1-s2.0-S0956566324003452-ga1_lrg.jpgDirect OA link when available
- Concepts
-
Biosensor, Nanotechnology, Colloidal gold, CRISPR, Materials science, DNA, Electrode, Chemistry, Nanoparticle, Physical chemistry, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
14Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 12, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
71Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| publication_date | 2024-04-25 |
| publication_year | 2024 |
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