Low dose oral ketamine treatment on post-traumatic stress disorder (PTSD) (OKTOP): An open-label pilot study Article Swipe
Bonnie L. Quigley
,
Adem Can
,
Megan Dutton
,
Cyrana C. Gallay
,
Grace Forsyth
,
Monique Jones
,
Fiona Randall
,
Timothy O. Wilson
,
Jim Lagopoulos
,
Daniel F. Hermens
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.11.26.24318024
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.11.26.24318024
Ketamine is being actively investigated as a rapid-acting treatment for many conditions with a stress-related psychopathology, including post-traumatic stress disorder (PTSD). The majority of studies regarding ketamine treatment for PTSD to date (including open-label and randomised control trials) have focused on intravenous (IV) ketamine administration. This administration route has limitations that can be overcome with oral ketamine. As such, this study undertook the first open-label low dose Oral Ketamine Trial on PTSD (OKTOP) to determine the safety and feasibility of sub-anaesthetic ketamine for PTSD symptom reduction. Participants with PTSD (n = 22 adults, aged 22-77 years, 55% female, 82% with comorbid depression) followed a weekly treatment course of low dose oral ketamine (titrated from 0.5 mg/kg to a maximum of 3.0 mg/kg) for six weeks. The primary outcome measure was the PTSD Checklist (PCL-5), with secondary measures including scales for depression, anxiety, stress, suicidality, sleep, and wellbeing. Mean PCL-5 scores were significantly reduced from a pre-ketamine baseline score of 40 to a post-ketamine score of 17 and remained at a reduced score (21) at follow-up, 1-month post-treatment. This reduction resulted in a response rate (defined as a ≥50% reduction in PCL-5 score from baseline) of 73% post-ketamine and 59% at follow-up. This response rate is comparable with IV ketamine trials for PTSD and suggests oral ketamine administration is a feasible and tolerable treatment for PTSD.
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Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.11.26.24318024
- https://www.medrxiv.org/content/medrxiv/early/2024/12/05/2024.11.26.24318024.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405042829
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405042829Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2024.11.26.24318024Digital Object Identifier
- Title
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Low dose oral ketamine treatment on post-traumatic stress disorder (PTSD) (OKTOP): An open-label pilot studyWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-12-05Full publication date if available
- Authors
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Bonnie L. Quigley, Adem Can, Megan Dutton, Cyrana C. Gallay, Grace Forsyth, Monique Jones, Fiona Randall, Timothy O. Wilson, Jim Lagopoulos, Daniel F. HermensList of authors in order
- Landing page
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https://doi.org/10.1101/2024.11.26.24318024Publisher landing page
- PDF URL
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https://www.medrxiv.org/content/medrxiv/early/2024/12/05/2024.11.26.24318024.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.medrxiv.org/content/medrxiv/early/2024/12/05/2024.11.26.24318024.full.pdfDirect OA link when available
- Concepts
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Ketamine, Depression (economics), Medicine, Anxiety, Psychopathology, Anesthesia, Psychiatry, Macroeconomics, EconomicsTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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42Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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