Low Expression of Programmed Death 1 (PD-1), PD-1 Ligand 1 (PD-L1), and Low CD8+ T Lymphocyte Infiltration Identify a Subgroup of Patients With Gastric and Esophageal Adenocarcinoma With Severe Prognosis Article Swipe
Silvio Däster
,
Serenella Eppenberger‐Castori
,
Valentina Mele
,
Hannah M. Schäfer
,
L. Schmid
,
Benjamin Weixler
,
Savas D. Soysal
,
Raoul A. Droeser
,
Giulio C. Spagnoli
,
Christoph Kettelhack
,
Daniel Oertli
,
Luigi Terracciano
,
Luigi Tornillo
,
Urs von Holzen
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fmed.2020.00144
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fmed.2020.00144
Prognosis of gastric and esophageal cancer is poor and treatment improvements are needed. Programmed cell death 1 receptor (PD-1) interaction with its ligand PD-L1 in tumor micro-environment promotes immune tolerance and blocking monoclonal antibodies have entered clinical practice. However, clinical significance of PD-1 and PD-L1 expression in gastric and esophageal adenocarcinomas, particularly in non-Asian patients, is still unclear. Three tissue microarrays including 190 clinically annotated esophageal (n = 31) and gastric (n = 159) adenocarcinomas and 58 paired mucosa specimens, were stained with PD-1, PD-L1, and CD8-specific reagents in indirect immunohistochemistry assays. PD-L1 expression was detectable in 23.2% of cancer specimens. High PD-1 expression was detectable in 37.3% of cases and high CD8+ infiltration in 76%. PD-L1 and high PD1 expression significantly correlated with each other (r s = 0.404, P < 0.0001) and both significantly correlated with CD8+ infiltration (r s = 0.435, P = 0.0003, and r s = 0.444; P = 0.0004, respectively). CD8+ lymphocyte infiltration correlated with improved survival in univariate (P = 0.009), but not multivariate analysis. Most interestingly, multivariate analysis and Kaplan-Meier curves indicate that combined low PD-1/PD-L1 expression and low CD8+ lymphocyte infiltration significantly correlate with poor prognosis. Our data document the clinical significance of a microenvironmental signature including PD-1/PD-L1 expression and CD8+ lymphocyte infiltration in gastric and esophageal adenocarcinomas and contribute to identify a patients' subset requiring more aggressive peri-operative treatments.
Related Topics
Concepts
Infiltration (HVAC)
CD8
Esophageal adenocarcinoma
PD-L1
Lymphocyte
Medicine
Tumor-infiltrating lymphocytes
Adenocarcinoma
Pathology
Cancer research
Immune system
Internal medicine
Immunology
Immunotherapy
Cancer
Materials science
Composite material
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmed.2020.00144
- https://www.frontiersin.org/articles/10.3389/fmed.2020.00144/pdf
- OA Status
- gold
- Cited By
- 16
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3021168337
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3021168337Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fmed.2020.00144Digital Object Identifier
- Title
-
Low Expression of Programmed Death 1 (PD-1), PD-1 Ligand 1 (PD-L1), and Low CD8+ T Lymphocyte Infiltration Identify a Subgroup of Patients With Gastric and Esophageal Adenocarcinoma With Severe PrognosisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-04-28Full publication date if available
- Authors
-
Silvio Däster, Serenella Eppenberger‐Castori, Valentina Mele, Hannah M. Schäfer, L. Schmid, Benjamin Weixler, Savas D. Soysal, Raoul A. Droeser, Giulio C. Spagnoli, Christoph Kettelhack, Daniel Oertli, Luigi Terracciano, Luigi Tornillo, Urs von HolzenList of authors in order
- Landing page
-
https://doi.org/10.3389/fmed.2020.00144Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fmed.2020.00144/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fmed.2020.00144/pdfDirect OA link when available
- Concepts
-
Infiltration (HVAC), CD8, Esophageal adenocarcinoma, PD-L1, Lymphocyte, Medicine, Tumor-infiltrating lymphocytes, Adenocarcinoma, Pathology, Cancer research, Immune system, Internal medicine, Immunology, Immunotherapy, Cancer, Materials science, Composite materialTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
16Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 6, 2022: 7, 2021: 3Per-year citation counts (last 5 years)
- References (count)
-
50Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3021168337 |
|---|---|
| doi | https://doi.org/10.3389/fmed.2020.00144 |
| ids.doi | https://doi.org/10.3389/fmed.2020.00144 |
| ids.mag | 3021168337 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/32411711 |
| ids.openalex | https://openalex.org/W3021168337 |
| fwci | 1.60940456 |
| type | article |
| title | Low Expression of Programmed Death 1 (PD-1), PD-1 Ligand 1 (PD-L1), and Low CD8+ T Lymphocyte Infiltration Identify a Subgroup of Patients With Gastric and Esophageal Adenocarcinoma With Severe Prognosis |
| biblio.issue | |
| biblio.volume | 7 |
| biblio.last_page | 144 |
| biblio.first_page | 144 |
| topics[0].id | https://openalex.org/T10158 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2730 |
| topics[0].subfield.display_name | Oncology |
| topics[0].display_name | Cancer Immunotherapy and Biomarkers |
| topics[1].id | https://openalex.org/T10696 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9990000128746033 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2740 |
| topics[1].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[1].display_name | Gastric Cancer Management and Outcomes |
| topics[2].id | https://openalex.org/T11485 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9984999895095825 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2715 |
| topics[2].subfield.display_name | Gastroenterology |
| topics[2].display_name | Gastrointestinal Tumor Research and Treatment |
| is_xpac | False |
| apc_list.value | 2490 |
| apc_list.currency | USD |
| apc_list.value_usd | 2490 |
| apc_paid.value | 2490 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2490 |
| concepts[0].id | https://openalex.org/C153400128 |
| concepts[0].level | 2 |
| concepts[0].score | 0.6851269006729126 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q3150731 |
| concepts[0].display_name | Infiltration (HVAC) |
| concepts[1].id | https://openalex.org/C167672396 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6421535611152649 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q417800 |
| concepts[1].display_name | CD8 |
| concepts[2].id | https://openalex.org/C2992824209 |
| concepts[2].level | 4 |
| concepts[2].score | 0.5970422029495239 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q372701 |
| concepts[2].display_name | Esophageal adenocarcinoma |
| concepts[3].id | https://openalex.org/C2781053074 |
| concepts[3].level | 4 |
| concepts[3].score | 0.496521532535553 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q21100639 |
| concepts[3].display_name | PD-L1 |
| concepts[4].id | https://openalex.org/C2777761686 |
| concepts[4].level | 2 |
| concepts[4].score | 0.476802796125412 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q715347 |
| concepts[4].display_name | Lymphocyte |
| concepts[5].id | https://openalex.org/C71924100 |
| concepts[5].level | 0 |
| concepts[5].score | 0.468797504901886 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[5].display_name | Medicine |
| concepts[6].id | https://openalex.org/C2778326572 |
| concepts[6].level | 4 |
| concepts[6].score | 0.4469899535179138 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7852668 |
| concepts[6].display_name | Tumor-infiltrating lymphocytes |
| concepts[7].id | https://openalex.org/C2781182431 |
| concepts[7].level | 3 |
| concepts[7].score | 0.40039053559303284 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q356033 |
| concepts[7].display_name | Adenocarcinoma |
| concepts[8].id | https://openalex.org/C142724271 |
| concepts[8].level | 1 |
| concepts[8].score | 0.38073354959487915 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[8].display_name | Pathology |
| concepts[9].id | https://openalex.org/C502942594 |
| concepts[9].level | 1 |
| concepts[9].score | 0.33934128284454346 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[9].display_name | Cancer research |
| concepts[10].id | https://openalex.org/C8891405 |
| concepts[10].level | 2 |
| concepts[10].score | 0.3351353406906128 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[10].display_name | Immune system |
| concepts[11].id | https://openalex.org/C126322002 |
| concepts[11].level | 1 |
| concepts[11].score | 0.3070562183856964 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[11].display_name | Internal medicine |
| concepts[12].id | https://openalex.org/C203014093 |
| concepts[12].level | 1 |
| concepts[12].score | 0.2122296392917633 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[12].display_name | Immunology |
| concepts[13].id | https://openalex.org/C2777701055 |
| concepts[13].level | 3 |
| concepts[13].score | 0.1255778968334198 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q1427096 |
| concepts[13].display_name | Immunotherapy |
| concepts[14].id | https://openalex.org/C121608353 |
| concepts[14].level | 2 |
| concepts[14].score | 0.1146666407585144 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[14].display_name | Cancer |
| concepts[15].id | https://openalex.org/C192562407 |
| concepts[15].level | 0 |
| concepts[15].score | 0.0857548713684082 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[15].display_name | Materials science |
| concepts[16].id | https://openalex.org/C159985019 |
| concepts[16].level | 1 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q181790 |
| concepts[16].display_name | Composite material |
| keywords[0].id | https://openalex.org/keywords/infiltration |
| keywords[0].score | 0.6851269006729126 |
| keywords[0].display_name | Infiltration (HVAC) |
| keywords[1].id | https://openalex.org/keywords/cd8 |
| keywords[1].score | 0.6421535611152649 |
| keywords[1].display_name | CD8 |
| keywords[2].id | https://openalex.org/keywords/esophageal-adenocarcinoma |
| keywords[2].score | 0.5970422029495239 |
| keywords[2].display_name | Esophageal adenocarcinoma |
| keywords[3].id | https://openalex.org/keywords/pd-l1 |
| keywords[3].score | 0.496521532535553 |
| keywords[3].display_name | PD-L1 |
| keywords[4].id | https://openalex.org/keywords/lymphocyte |
| keywords[4].score | 0.476802796125412 |
| keywords[4].display_name | Lymphocyte |
| keywords[5].id | https://openalex.org/keywords/medicine |
| keywords[5].score | 0.468797504901886 |
| keywords[5].display_name | Medicine |
| keywords[6].id | https://openalex.org/keywords/tumor-infiltrating-lymphocytes |
| keywords[6].score | 0.4469899535179138 |
| keywords[6].display_name | Tumor-infiltrating lymphocytes |
| keywords[7].id | https://openalex.org/keywords/adenocarcinoma |
| keywords[7].score | 0.40039053559303284 |
| keywords[7].display_name | Adenocarcinoma |
| keywords[8].id | https://openalex.org/keywords/pathology |
| keywords[8].score | 0.38073354959487915 |
| keywords[8].display_name | Pathology |
| keywords[9].id | https://openalex.org/keywords/cancer-research |
| keywords[9].score | 0.33934128284454346 |
| keywords[9].display_name | Cancer research |
| keywords[10].id | https://openalex.org/keywords/immune-system |
| keywords[10].score | 0.3351353406906128 |
| keywords[10].display_name | Immune system |
| keywords[11].id | https://openalex.org/keywords/internal-medicine |
| keywords[11].score | 0.3070562183856964 |
| keywords[11].display_name | Internal medicine |
| keywords[12].id | https://openalex.org/keywords/immunology |
| keywords[12].score | 0.2122296392917633 |
| keywords[12].display_name | Immunology |
| keywords[13].id | https://openalex.org/keywords/immunotherapy |
| keywords[13].score | 0.1255778968334198 |
| keywords[13].display_name | Immunotherapy |
| keywords[14].id | https://openalex.org/keywords/cancer |
| keywords[14].score | 0.1146666407585144 |
| keywords[14].display_name | Cancer |
| keywords[15].id | https://openalex.org/keywords/materials-science |
| keywords[15].score | 0.0857548713684082 |
| keywords[15].display_name | Materials science |
| language | en |
| locations[0].id | doi:10.3389/fmed.2020.00144 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2597052008 |
| locations[0].source.issn | 2296-858X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2296-858X |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Medicine |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_lineage_names | Frontiers Media |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.frontiersin.org/articles/10.3389/fmed.2020.00144/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Medicine |
| locations[0].landing_page_url | https://doi.org/10.3389/fmed.2020.00144 |
| locations[1].id | pmid:32411711 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in medicine |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/32411711 |
| locations[2].id | pmh:oai:doaj.org/article:4751443826274a429cf6b643bb3a11d0 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Frontiers in Medicine, Vol 7 (2020) |
| locations[2].landing_page_url | https://doaj.org/article/4751443826274a429cf6b643bb3a11d0 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:7199486 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Front Med (Lausanne) |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7199486 |
| locations[4].id | pmh:oai:scholarworks.indianapolis.iu.edu:1805/23476 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306522653 |
| locations[4].source.issn | |
| locations[4].source.type | journal |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | True |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PMC |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].license | cc-by |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Article |
| locations[4].license_id | https://openalex.org/licenses/cc-by |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | PMC |
| locations[4].landing_page_url | https://hdl.handle.net/1805/23476 |
| locations[5].id | pmh:oai:scholarworks.iupui.edu:1805/23476 |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S4306400987 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | IUScholarWorks (Indiana University) |
| locations[5].source.host_organization | https://openalex.org/I592451 |
| locations[5].source.host_organization_name | Indiana University |
| locations[5].source.host_organization_lineage | https://openalex.org/I592451 |
| locations[5].license | cc-by |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | Article |
| locations[5].license_id | https://openalex.org/licenses/cc-by |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | PMC |
| locations[5].landing_page_url | http://hdl.handle.net/1805/23476 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5025479665 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-5188-4908 |
| authorships[0].author.display_name | Silvio Däster |
| authorships[0].countries | CH |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I2802542264 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[0].institutions[0].id | https://openalex.org/I2802542264 |
| authorships[0].institutions[0].ror | https://ror.org/04k51q396 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I2802542264 |
| authorships[0].institutions[0].country_code | CH |
| authorships[0].institutions[0].display_name | University Hospital of Basel |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Silvio Däster |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[1].author.id | https://openalex.org/A5031592069 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-2194-2913 |
| authorships[1].author.display_name | Serenella Eppenberger‐Castori |
| authorships[1].countries | CH |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2802542264 |
| authorships[1].affiliations[0].raw_affiliation_string | Division of Molecular Pathology, Institute of Pathology, University Hospital Basel, Basel, Switzerland |
| authorships[1].institutions[0].id | https://openalex.org/I2802542264 |
| authorships[1].institutions[0].ror | https://ror.org/04k51q396 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I2802542264 |
| authorships[1].institutions[0].country_code | CH |
| authorships[1].institutions[0].display_name | University Hospital of Basel |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Serenella Eppenberger-Castori |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Division of Molecular Pathology, Institute of Pathology, University Hospital Basel, Basel, Switzerland |
| authorships[2].author.id | https://openalex.org/A5067238118 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-7648-0835 |
| authorships[2].author.display_name | Valentina Mele |
| authorships[2].countries | CH |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1850255 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Biomedicine, University of Basel, Basel, Switzerland |
| authorships[2].institutions[0].id | https://openalex.org/I1850255 |
| authorships[2].institutions[0].ror | https://ror.org/02s6k3f65 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I1850255 |
| authorships[2].institutions[0].country_code | CH |
| authorships[2].institutions[0].display_name | University of Basel |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Valentina Mele |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Biomedicine, University of Basel, Basel, Switzerland |
| authorships[3].author.id | https://openalex.org/A5110718082 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Hannah M. Schäfer |
| authorships[3].countries | CH |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2802542264 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[3].institutions[0].id | https://openalex.org/I2802542264 |
| authorships[3].institutions[0].ror | https://ror.org/04k51q396 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I2802542264 |
| authorships[3].institutions[0].country_code | CH |
| authorships[3].institutions[0].display_name | University Hospital of Basel |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Hannah M. Schäfer |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[4].author.id | https://openalex.org/A5070027070 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-9176-9303 |
| authorships[4].author.display_name | L. Schmid |
| authorships[4].countries | CH |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I2802542264 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[4].institutions[0].id | https://openalex.org/I2802542264 |
| authorships[4].institutions[0].ror | https://ror.org/04k51q396 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I2802542264 |
| authorships[4].institutions[0].country_code | CH |
| authorships[4].institutions[0].display_name | University Hospital of Basel |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Lukas Schmid |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[5].author.id | https://openalex.org/A5061535451 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-3652-4792 |
| authorships[5].author.display_name | Benjamin Weixler |
| authorships[5].countries | CH |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I2802542264 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[5].institutions[0].id | https://openalex.org/I2802542264 |
| authorships[5].institutions[0].ror | https://ror.org/04k51q396 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I2802542264 |
| authorships[5].institutions[0].country_code | CH |
| authorships[5].institutions[0].display_name | University Hospital of Basel |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Benjamin Weixler |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[6].author.id | https://openalex.org/A5057556096 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-0761-449X |
| authorships[6].author.display_name | Savas D. Soysal |
| authorships[6].countries | CH |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I2802542264 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[6].institutions[0].id | https://openalex.org/I2802542264 |
| authorships[6].institutions[0].ror | https://ror.org/04k51q396 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I2802542264 |
| authorships[6].institutions[0].country_code | CH |
| authorships[6].institutions[0].display_name | University Hospital of Basel |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Savas D. Soysal |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[7].author.id | https://openalex.org/A5040620123 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-2000-651X |
| authorships[7].author.display_name | Raoul A. Droeser |
| authorships[7].countries | CH |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I2802542264 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[7].institutions[0].id | https://openalex.org/I2802542264 |
| authorships[7].institutions[0].ror | https://ror.org/04k51q396 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I2802542264 |
| authorships[7].institutions[0].country_code | CH |
| authorships[7].institutions[0].display_name | University Hospital of Basel |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Raoul A. Droeser |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[8].author.id | https://openalex.org/A5038497681 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-1904-2011 |
| authorships[8].author.display_name | Giulio C. Spagnoli |
| authorships[8].countries | IT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210133672, https://openalex.org/I4210155236 |
| authorships[8].affiliations[0].raw_affiliation_string | National Research Council, Institute of Translational Pharmacology, Rome, Italy |
| authorships[8].institutions[0].id | https://openalex.org/I4210133672 |
| authorships[8].institutions[0].ror | https://ror.org/03ta8pf33 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210133672, https://openalex.org/I4210155236 |
| authorships[8].institutions[0].country_code | IT |
| authorships[8].institutions[0].display_name | Istituto di Farmacologia Traslazionale |
| authorships[8].institutions[1].id | https://openalex.org/I4210155236 |
| authorships[8].institutions[1].ror | https://ror.org/04zaypm56 |
| authorships[8].institutions[1].type | nonprofit |
| authorships[8].institutions[1].lineage | https://openalex.org/I4210155236 |
| authorships[8].institutions[1].country_code | IT |
| authorships[8].institutions[1].display_name | National Research Council |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Giulio C. Spagnoli |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | National Research Council, Institute of Translational Pharmacology, Rome, Italy |
| authorships[9].author.id | https://openalex.org/A5066210971 |
| authorships[9].author.orcid | https://orcid.org/0009-0000-3913-0775 |
| authorships[9].author.display_name | Christoph Kettelhack |
| authorships[9].countries | CH |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I2802542264 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[9].institutions[0].id | https://openalex.org/I2802542264 |
| authorships[9].institutions[0].ror | https://ror.org/04k51q396 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I2802542264 |
| authorships[9].institutions[0].country_code | CH |
| authorships[9].institutions[0].display_name | University Hospital of Basel |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Christoph Kettelhack |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[10].author.id | https://openalex.org/A5008894098 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-1936-300X |
| authorships[10].author.display_name | Daniel Oertli |
| authorships[10].countries | CH |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I2802542264 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[10].institutions[0].id | https://openalex.org/I2802542264 |
| authorships[10].institutions[0].ror | https://ror.org/04k51q396 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I2802542264 |
| authorships[10].institutions[0].country_code | CH |
| authorships[10].institutions[0].display_name | University Hospital of Basel |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Daniel Oertli |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[11].author.id | https://openalex.org/A5023044832 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-9393-9660 |
| authorships[11].author.display_name | Luigi Terracciano |
| authorships[11].countries | CH |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I2802542264 |
| authorships[11].affiliations[0].raw_affiliation_string | Division of Molecular Pathology, Institute of Pathology, University Hospital Basel, Basel, Switzerland |
| authorships[11].institutions[0].id | https://openalex.org/I2802542264 |
| authorships[11].institutions[0].ror | https://ror.org/04k51q396 |
| authorships[11].institutions[0].type | healthcare |
| authorships[11].institutions[0].lineage | https://openalex.org/I2802542264 |
| authorships[11].institutions[0].country_code | CH |
| authorships[11].institutions[0].display_name | University Hospital of Basel |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Luigi Terracciano |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Division of Molecular Pathology, Institute of Pathology, University Hospital Basel, Basel, Switzerland |
| authorships[12].author.id | https://openalex.org/A5034103482 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-3610-3733 |
| authorships[12].author.display_name | Luigi Tornillo |
| authorships[12].countries | CH |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I2802542264 |
| authorships[12].affiliations[0].raw_affiliation_string | Division of Molecular Pathology, Institute of Pathology, University Hospital Basel, Basel, Switzerland |
| authorships[12].institutions[0].id | https://openalex.org/I2802542264 |
| authorships[12].institutions[0].ror | https://ror.org/04k51q396 |
| authorships[12].institutions[0].type | healthcare |
| authorships[12].institutions[0].lineage | https://openalex.org/I2802542264 |
| authorships[12].institutions[0].country_code | CH |
| authorships[12].institutions[0].display_name | University Hospital of Basel |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Luigi Tornillo |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Division of Molecular Pathology, Institute of Pathology, University Hospital Basel, Basel, Switzerland |
| authorships[13].author.id | https://openalex.org/A5022845568 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-3746-6237 |
| authorships[13].author.display_name | Urs von Holzen |
| authorships[13].countries | CH, US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I2802542264 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Surgery, University Hospital Basel, Basel, Switzerland |
| authorships[13].affiliations[1].institution_ids | https://openalex.org/I4210160959 |
| authorships[13].affiliations[1].raw_affiliation_string | Goshen Center for Cancer Care, Goshen, IN, United States |
| authorships[13].affiliations[2].institution_ids | https://openalex.org/I4210134870, https://openalex.org/I4394709130 |
| authorships[13].affiliations[2].raw_affiliation_string | Harper Cancer Research Institute, Indiana University School of Medicine South Bend, South Bend, IN, United States |
| authorships[13].institutions[0].id | https://openalex.org/I4394709130 |
| authorships[13].institutions[0].ror | https://ror.org/02ets8c94 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I4394709130, https://openalex.org/I592451 |
| authorships[13].institutions[0].country_code | |
| authorships[13].institutions[0].display_name | Indiana University School of Medicine |
| authorships[13].institutions[1].id | https://openalex.org/I2802542264 |
| authorships[13].institutions[1].ror | https://ror.org/04k51q396 |
| authorships[13].institutions[1].type | healthcare |
| authorships[13].institutions[1].lineage | https://openalex.org/I2802542264 |
| authorships[13].institutions[1].country_code | CH |
| authorships[13].institutions[1].display_name | University Hospital of Basel |
| authorships[13].institutions[2].id | https://openalex.org/I4210160959 |
| authorships[13].institutions[2].ror | https://ror.org/04sggs879 |
| authorships[13].institutions[2].type | healthcare |
| authorships[13].institutions[2].lineage | https://openalex.org/I4210160959 |
| authorships[13].institutions[2].country_code | US |
| authorships[13].institutions[2].display_name | Goshen Health |
| authorships[13].institutions[3].id | https://openalex.org/I4210134870 |
| authorships[13].institutions[3].ror | https://ror.org/02s1hvj37 |
| authorships[13].institutions[3].type | education |
| authorships[13].institutions[3].lineage | https://openalex.org/I4210134870, https://openalex.org/I592451 |
| authorships[13].institutions[3].country_code | US |
| authorships[13].institutions[3].display_name | Indiana University South Bend |
| authorships[13].author_position | last |
| authorships[13].raw_author_name | Urs von Holzen |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Surgery, University Hospital Basel, Basel, Switzerland, Goshen Center for Cancer Care, Goshen, IN, United States, Harper Cancer Research Institute, Indiana University School of Medicine South Bend, South Bend, IN, United States |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.frontiersin.org/articles/10.3389/fmed.2020.00144/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Low Expression of Programmed Death 1 (PD-1), PD-1 Ligand 1 (PD-L1), and Low CD8+ T Lymphocyte Infiltration Identify a Subgroup of Patients With Gastric and Esophageal Adenocarcinoma With Severe Prognosis |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10158 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2730 |
| primary_topic.subfield.display_name | Oncology |
| primary_topic.display_name | Cancer Immunotherapy and Biomarkers |
| related_works | https://openalex.org/W3129526147, https://openalex.org/W4283274326, https://openalex.org/W4384207630, https://openalex.org/W3097631244, https://openalex.org/W3038679504, https://openalex.org/W3111616378, https://openalex.org/W3093619991, https://openalex.org/W2904835427, https://openalex.org/W2980387286, https://openalex.org/W3173283805 |
| cited_by_count | 16 |
| counts_by_year[0].year | 2023 |
| counts_by_year[0].cited_by_count | 6 |
| counts_by_year[1].year | 2022 |
| counts_by_year[1].cited_by_count | 7 |
| counts_by_year[2].year | 2021 |
| counts_by_year[2].cited_by_count | 3 |
| locations_count | 6 |
| best_oa_location.id | doi:10.3389/fmed.2020.00144 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2597052008 |
| best_oa_location.source.issn | 2296-858X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2296-858X |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Medicine |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_lineage_names | Frontiers Media |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.frontiersin.org/articles/10.3389/fmed.2020.00144/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Medicine |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fmed.2020.00144 |
| primary_location.id | doi:10.3389/fmed.2020.00144 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2597052008 |
| primary_location.source.issn | 2296-858X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2296-858X |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Medicine |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_lineage_names | Frontiers Media |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.frontiersin.org/articles/10.3389/fmed.2020.00144/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Medicine |
| primary_location.landing_page_url | https://doi.org/10.3389/fmed.2020.00144 |
| publication_date | 2020-04-28 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W1757407923, https://openalex.org/W4211048478, https://openalex.org/W4211130279, https://openalex.org/W2016732129, https://openalex.org/W2229552798, https://openalex.org/W2097995306, https://openalex.org/W2152897456, https://openalex.org/W2222086386, https://openalex.org/W2198093519, https://openalex.org/W2588916311, https://openalex.org/W2529484692, https://openalex.org/W2767857925, https://openalex.org/W2347070489, https://openalex.org/W2179883330, https://openalex.org/W2808750176, https://openalex.org/W2793364080, https://openalex.org/W2763064222, https://openalex.org/W2802657011, https://openalex.org/W2109485845, https://openalex.org/W2049491375, https://openalex.org/W2150024391, https://openalex.org/W2570401594, https://openalex.org/W2126547130, https://openalex.org/W2884397450, https://openalex.org/W2130207101, https://openalex.org/W2178326595, https://openalex.org/W2521930878, https://openalex.org/W2338607273, https://openalex.org/W2793476888, https://openalex.org/W1498454097, https://openalex.org/W2095864883, https://openalex.org/W995625926, https://openalex.org/W1976269164, https://openalex.org/W1999075493, https://openalex.org/W6685713197, https://openalex.org/W2557604612, https://openalex.org/W2772456202, https://openalex.org/W2300582328, https://openalex.org/W2298468092, https://openalex.org/W6674370923, https://openalex.org/W1550322418, https://openalex.org/W2000560823, https://openalex.org/W2887629404, https://openalex.org/W2051929083, https://openalex.org/W2070332618, https://openalex.org/W2313945592, https://openalex.org/W2792380195, https://openalex.org/W2927046270, https://openalex.org/W2560367415, https://openalex.org/W2572174216 |
| referenced_works_count | 50 |
| abstract_inverted_index.1 | 16 |
| abstract_inverted_index.< | 131 |
| abstract_inverted_index.= | 67, 72, 128, 142, 145, 150, 153, 166 |
| abstract_inverted_index.a | 202, 221 |
| abstract_inverted_index.58 | 76 |
| abstract_inverted_index.in | 24, 46, 52, 88, 96, 106, 114, 163, 212 |
| abstract_inverted_index.is | 6, 55 |
| abstract_inverted_index.of | 1, 41, 98, 108, 201 |
| abstract_inverted_index.to | 219 |
| abstract_inverted_index.190 | 62 |
| abstract_inverted_index.31) | 68 |
| abstract_inverted_index.Our | 195 |
| abstract_inverted_index.PD1 | 119 |
| abstract_inverted_index.and | 3, 8, 30, 43, 48, 69, 75, 85, 110, 117, 133, 147, 176, 185, 208, 214, 217 |
| abstract_inverted_index.are | 11 |
| abstract_inverted_index.but | 168 |
| abstract_inverted_index.its | 21 |
| abstract_inverted_index.low | 182, 186 |
| abstract_inverted_index.not | 169 |
| abstract_inverted_index.the | 198 |
| abstract_inverted_index.was | 94, 104 |
| abstract_inverted_index.159) | 73 |
| abstract_inverted_index.76%. | 115 |
| abstract_inverted_index.CD8+ | 112, 138, 156, 187, 209 |
| abstract_inverted_index.High | 101 |
| abstract_inverted_index.Most | 172 |
| abstract_inverted_index.PD-1 | 42, 102 |
| abstract_inverted_index.both | 134 |
| abstract_inverted_index.cell | 14 |
| abstract_inverted_index.data | 196 |
| abstract_inverted_index.each | 124 |
| abstract_inverted_index.have | 34 |
| abstract_inverted_index.high | 111, 118 |
| abstract_inverted_index.more | 225 |
| abstract_inverted_index.poor | 7, 193 |
| abstract_inverted_index.that | 180 |
| abstract_inverted_index.were | 80 |
| abstract_inverted_index.with | 20, 82, 123, 137, 160, 192 |
| abstract_inverted_index.23.2% | 97 |
| abstract_inverted_index.37.3% | 107 |
| abstract_inverted_index.PD-1, | 83 |
| abstract_inverted_index.PD-L1 | 23, 44, 92, 116 |
| abstract_inverted_index.Three | 58 |
| abstract_inverted_index.cases | 109 |
| abstract_inverted_index.death | 15 |
| abstract_inverted_index.other | 125 |
| abstract_inverted_index.still | 56 |
| abstract_inverted_index.tumor | 25 |
| abstract_inverted_index.(PD-1) | 18 |
| abstract_inverted_index.0.404, | 129 |
| abstract_inverted_index.0.435, | 143 |
| abstract_inverted_index.0.444; | 151 |
| abstract_inverted_index.PD-L1, | 84 |
| abstract_inverted_index.cancer | 5, 99 |
| abstract_inverted_index.curves | 178 |
| abstract_inverted_index.immune | 28 |
| abstract_inverted_index.ligand | 22 |
| abstract_inverted_index.mucosa | 78 |
| abstract_inverted_index.paired | 77 |
| abstract_inverted_index.subset | 223 |
| abstract_inverted_index.tissue | 59 |
| abstract_inverted_index.0.0001) | 132 |
| abstract_inverted_index.0.0003, | 146 |
| abstract_inverted_index.0.0004, | 154 |
| abstract_inverted_index.0.009), | 167 |
| abstract_inverted_index.assays. | 91 |
| abstract_inverted_index.entered | 35 |
| abstract_inverted_index.gastric | 2, 47, 70, 213 |
| abstract_inverted_index.needed. | 12 |
| abstract_inverted_index.stained | 81 |
| abstract_inverted_index.<i>P</i> | 130, 144, 152 |
| abstract_inverted_index.<i>r</i> | 148 |
| abstract_inverted_index.However, | 38 |
| abstract_inverted_index.analysis | 175 |
| abstract_inverted_index.blocking | 31 |
| abstract_inverted_index.clinical | 36, 39, 199 |
| abstract_inverted_index.combined | 181 |
| abstract_inverted_index.document | 197 |
| abstract_inverted_index.identify | 220 |
| abstract_inverted_index.improved | 161 |
| abstract_inverted_index.indicate | 179 |
| abstract_inverted_index.indirect | 89 |
| abstract_inverted_index.promotes | 27 |
| abstract_inverted_index.reagents | 87 |
| abstract_inverted_index.receptor | 17 |
| abstract_inverted_index.survival | 162 |
| abstract_inverted_index.unclear. | 57 |
| abstract_inverted_index.(<i>P</i> | 165 |
| abstract_inverted_index.(<i>n</i> | 66, 71 |
| abstract_inverted_index.(<i>r</i> | 126, 140 |
| abstract_inverted_index.Prognosis | 0 |
| abstract_inverted_index.analysis. | 171 |
| abstract_inverted_index.annotated | 64 |
| abstract_inverted_index.correlate | 191 |
| abstract_inverted_index.including | 61, 205 |
| abstract_inverted_index.non-Asian | 53 |
| abstract_inverted_index.patients' | 222 |
| abstract_inverted_index.patients, | 54 |
| abstract_inverted_index.practice. | 37 |
| abstract_inverted_index.requiring | 224 |
| abstract_inverted_index.signature | 204 |
| abstract_inverted_index.tolerance | 29 |
| abstract_inverted_index.treatment | 9 |
| abstract_inverted_index.PD-1/PD-L1 | 183, 206 |
| abstract_inverted_index.Programmed | 13 |
| abstract_inverted_index.aggressive | 226 |
| abstract_inverted_index.antibodies | 33 |
| abstract_inverted_index.clinically | 63 |
| abstract_inverted_index.contribute | 218 |
| abstract_inverted_index.correlated | 122, 136, 159 |
| abstract_inverted_index.detectable | 95, 105 |
| abstract_inverted_index.esophageal | 4, 49, 65, 215 |
| abstract_inverted_index.expression | 45, 93, 103, 120, 184, 207 |
| abstract_inverted_index.lymphocyte | 157, 188, 210 |
| abstract_inverted_index.monoclonal | 32 |
| abstract_inverted_index.prognosis. | 194 |
| abstract_inverted_index.specimens, | 79 |
| abstract_inverted_index.specimens. | 100 |
| abstract_inverted_index.univariate | 164 |
| abstract_inverted_index.interaction | 19 |
| abstract_inverted_index.microarrays | 60 |
| abstract_inverted_index.treatments. | 228 |
| abstract_inverted_index.<sub>s</sub> | 127, 141, 149 |
| abstract_inverted_index.CD8-specific | 86 |
| abstract_inverted_index.Kaplan-Meier | 177 |
| abstract_inverted_index.improvements | 10 |
| abstract_inverted_index.infiltration | 113, 139, 158, 189, 211 |
| abstract_inverted_index.multivariate | 170, 174 |
| abstract_inverted_index.particularly | 51 |
| abstract_inverted_index.significance | 40, 200 |
| abstract_inverted_index.significantly | 121, 135, 190 |
| abstract_inverted_index.interestingly, | 173 |
| abstract_inverted_index.peri-operative | 227 |
| abstract_inverted_index.respectively). | 155 |
| abstract_inverted_index.adenocarcinomas | 74, 216 |
| abstract_inverted_index.adenocarcinomas, | 50 |
| abstract_inverted_index.micro-environment | 26 |
| abstract_inverted_index.microenvironmental | 203 |
| abstract_inverted_index.immunohistochemistry | 90 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5025479665 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 14 |
| corresponding_institution_ids | https://openalex.org/I2802542264 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.49000000953674316 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.8369564 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |