Low FAT4 expression is associated with a poor prognosis in gastric cancer patients Article Swipe
Xiaoting Jiang
,
Zhengchuang Liu
,
Yingjie Xia
,
Jungang Luo
,
Ji Xu
,
Xujun He
,
Hou‐Quan Tao
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.23702
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.23702
In this study, we investigated the role of Fat atypical cadherin 4 (FAT4) in gastric cancer (GC) progression. Immunohistochemical analysis showed lower FAT4 expression in tumor tissues from GC patients than in normal gastric epithelium. Lower FAT4 expression was associated with poor prognosis, tumor size and invasion, and lymph node and distant metastases. Multivariate analysis showed that TNM stage, lymph node and distant metastases, Lauren classification, and FAT4 expression were independent prognostic factors in GC. Methylation-specific PCR analysis showed increased FAT4 promoter methylation in GC tumor tissues and cell lines. Higher FAT4 promoter methylation was associated with low FAT4 expression and a poor prognosis. BGC-823 cells showed increased FAT4 expression upon treatment with 5-azacytidine, demethylating agent. FAT4 knockdown in BGC-823 cells led to increased cell proliferation, migration and invasiveness. Moreover, xenografts of BGC-823 cells with FAT4 knockdown showed enhanced tumor growth and metastasis in nude mice. These findings demonstrate that low FAT4 expression is associated with a poor prognosis in GC patients.
Related Topics
Concepts
Gene knockdown
Cancer research
Immunohistochemistry
Medicine
Methylation
Demethylating agent
Metastasis
Oncology
DNA methylation
Pathology
Cancer
Internal medicine
Biology
Gene expression
Cell culture
Gene
Biochemistry
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18632/oncotarget.23702
- http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=23702&path%5B%5D=74605
- OA Status
- diamond
- Cited By
- 23
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2778869206
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2778869206Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.18632/oncotarget.23702Digital Object Identifier
- Title
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Low FAT4 expression is associated with a poor prognosis in gastric cancer patientsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2017Year of publication
- Publication date
-
2017-12-26Full publication date if available
- Authors
-
Xiaoting Jiang, Zhengchuang Liu, Yingjie Xia, Jungang Luo, Ji Xu, Xujun He, Hou‐Quan TaoList of authors in order
- Landing page
-
https://doi.org/10.18632/oncotarget.23702Publisher landing page
- PDF URL
-
https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=23702&path%5B%5D=74605Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=23702&path%5B%5D=74605Direct OA link when available
- Concepts
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Gene knockdown, Cancer research, Immunohistochemistry, Medicine, Methylation, Demethylating agent, Metastasis, Oncology, DNA methylation, Pathology, Cancer, Internal medicine, Biology, Gene expression, Cell culture, Gene, Biochemistry, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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23Total citation count in OpenAlex
- Citations by year (recent)
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2024: 2, 2023: 9, 2022: 3, 2021: 2, 2020: 6Per-year citation counts (last 5 years)
- References (count)
-
27Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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