Low geriatric nutritional risk index as a poor prognostic biomarker for immune checkpoint inhibitor treatment in solid cancer Article Swipe
Lilong Zhang
,
Kunpeng Wang
,
Tianrui Kuang
,
Wenhong Deng
,
Peng Hu
,
Weixing Wang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fnut.2023.1286583
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fnut.2023.1286583
Objective In this investigation, we focused on the geriatric nutritional risk index (GNRI), a comprehensive metric that takes into account the patient’s ideal weight, actual weight, and serum albumin levels to measure malnutrition. Our primary objective was to examine the predictive value of GNRI-defined malnutrition in determining the response to immunotherapy among cancer patients. Methods Relevant articles for this study were systematically searched in PubMed, the Cochrane Library, EMBASE, and Google Scholar up to July 2023. Our analysis evaluated overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR) as clinical outcomes. Results This analysis comprised a total of eleven articles encompassing 1,417 patients. The pooled results revealed that cancer patients with low GNRI levels exhibited shorter OS (HR: 2.64, 95% CI: 2.08–3.36, p < 0.001) and PFS (HR: 1.87, 95% CI: 1.46–2.41, p < 0.001), and lower ORR (OR: 0.46, 95% CI: 0.33–0.65, p < 0.001) and DCR (OR: 0.42, 95% CI: 0.29–0.61, p < 0.001). Sensitivity analyses confirmed that the above results were stable. Egger’s and Begg’s tests revealed that there was no publication bias in the above results. Conclusion Our results imply that the GNRI is a useful predictor of immunotherapy response in cancer patients.
Related Topics
Concepts
Biomarker
Medicine
Immune checkpoint
Nivolumab
Cancer
Oncology
Internal medicine
Immunotherapy
Biology
Biochemistry
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnut.2023.1286583
- https://www.frontiersin.org/articles/10.3389/fnut.2023.1286583/pdf?isPublishedV2=False
- OA Status
- gold
- Cited By
- 6
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4388126519
All OpenAlex metadata
Raw OpenAlex JSON
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- DOI
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- Title
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Low geriatric nutritional risk index as a poor prognostic biomarker for immune checkpoint inhibitor treatment in solid cancerWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-11-01Full publication date if available
- Authors
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Lilong Zhang, Kunpeng Wang, Tianrui Kuang, Wenhong Deng, Peng Hu, Weixing WangList of authors in order
- Landing page
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https://doi.org/10.3389/fnut.2023.1286583Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fnut.2023.1286583/pdf?isPublishedV2=FalseDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fnut.2023.1286583/pdf?isPublishedV2=FalseDirect OA link when available
- Concepts
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Biomarker, Medicine, Immune checkpoint, Nivolumab, Cancer, Oncology, Internal medicine, Immunotherapy, Biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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6Total citation count in OpenAlex
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2025: 4, 2024: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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