arXiv (Cornell University)
LPD: Learnable Prototypes with Diversity Regularization for Weakly Supervised Histopathology Segmentation
December 2025 • Khang Le, Tuan A. Vu, Ha Thach, Ngoc Bui Lam Quang, Thanh-Huy Nguyen, Minh Hoang Le, Zhu Han, Chandra Mohan, Hien Van Nguyen
Weakly supervised semantic segmentation (WSSS) in histopathology reduces pixel-level labeling by learning from image-level labels, but it is hindered by inter-class homogeneity, intra-class heterogeneity, and CAM-induced region shrinkage (global pooling-based class activation maps whose activations highlight only the most distinctive areas and miss nearby class regions). Recent works address these challenges by constructing a clustering prototype bank and then refining masks in a separate stage; however, such two-…