LRG1 promoted the expression of RUNX1 and CRC cell proliferation. Article Swipe

View

Zhou Ying , Xintian Zhang , Jingjing Zhang , Fang Jingyuan , Ge Zhizheng , Xiaobo Li ·

YOU? · · 2017 · Open Access · · DOI: https://doi.org/10.1371/journal.pone.0175122.g004

(a) SW480 and HCT116 cells were transfection with LRG1 siRNA, and the expression of the tested RUNXs was quantified by RT-PCR. (b) Cells were stimulated with rLRG1 (0–1,000 ng/ml) for 24 h, and the RUNX1 expression was determined by RT-PCR. (c) Cells were stimulated with rLRG1 (0–1000 ng/ml), and a CCK-8 assay was performed to evaluate cell proliferation. (d) The protein levels of cyclin D1, B, E, Bcl-2, Bax, and cleaved caspase-3 in response to LRG1 treatment in SW480 cells were analysed by Western blot. This figure shows representative images of repeated experiments, and the data are presented as the mean±standard deviation. Compared with NC, *P<0.05, **P<0.01, and ***P<0.001.

Related Topics

Concepts

RUNX1 Cell growth Expression (computer science) Cell biology Cancer research Biology Genetics Stem cell Computer science Haematopoiesis Programming language

Metadata

Type: paratext
Language: en
Landing Page: https://figshare.com/articles/figure/LRG1_promoted_the_expression_of_RUNX1_and_CRC_cell_proliferation_/4816420
OA Status: green
Related Works: 20
OpenAlex ID: https://openalex.org/W2978565228

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W2978565228

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1371/journal.pone.0175122.g004

Digital Object Identifier
Title: LRG1 promoted the expression of RUNX1 and CRC cell proliferation.

Work title
Type: paratext

OpenAlex work type
Language: en

Primary language
Publication year: 2017

Year of publication
Publication date: 2017-04-05

Full publication date if available
Authors: Zhou Ying, Xintian Zhang, Jingjing Zhang, Fang Jingyuan, Ge Zhizheng, Xiaobo Li

List of authors in order
Landing page: https://figshare.com/articles/figure/LRG1_promoted_the_expression_of_RUNX1_and_CRC_cell_proliferation_/4816420

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: green

Open access status per OpenAlex
OA URL: https://figshare.com/articles/figure/LRG1_promoted_the_expression_of_RUNX1_and_CRC_cell_proliferation_/4816420

Direct OA link when available
Concepts: RUNX1, Cell growth, Expression (computer science), Cell biology, Cancer research, Biology, Genetics, Stem cell, Computer science, Haematopoiesis, Programming language

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
Related works (count): 20

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W2978565228
doi	https://doi.org/10.1371/journal.pone.0175122.g004
ids.mag	2978565228
ids.openalex	https://openalex.org/W2978565228
fwci
type	paratext
title	LRG1 promoted the expression of RUNX1 and CRC cell proliferation.
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T14364
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9998000264167786
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2730
topics[0].subfield.display_name	Oncology
topics[0].display_name	Clusterin in disease pathology
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2778193527
concepts[0].level	4
concepts[0].score	0.579426646232605
concepts[0].wikidata	https://www.wikidata.org/wiki/Q15320451
concepts[0].display_name	RUNX1
concepts[1].id	https://openalex.org/C62112901
concepts[1].level	2
concepts[1].score	0.5605350732803345
concepts[1].wikidata	https://www.wikidata.org/wiki/Q189159
concepts[1].display_name	Cell growth
concepts[2].id	https://openalex.org/C90559484
concepts[2].level	2
concepts[2].score	0.44308382272720337
concepts[2].wikidata	https://www.wikidata.org/wiki/Q778379
concepts[2].display_name	Expression (computer science)
concepts[3].id	https://openalex.org/C95444343
concepts[3].level	1
concepts[3].score	0.4397045969963074
concepts[3].wikidata	https://www.wikidata.org/wiki/Q7141
concepts[3].display_name	Cell biology
concepts[4].id	https://openalex.org/C502942594
concepts[4].level	1
concepts[4].score	0.3957812488079071
concepts[4].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[4].display_name	Cancer research
concepts[5].id	https://openalex.org/C86803240
concepts[5].level	0
concepts[5].score	0.36080703139305115
concepts[5].wikidata	https://www.wikidata.org/wiki/Q420
concepts[5].display_name	Biology
concepts[6].id	https://openalex.org/C54355233
concepts[6].level	1
concepts[6].score	0.22121691703796387
concepts[6].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[6].display_name	Genetics
concepts[7].id	https://openalex.org/C28328180
concepts[7].level	2
concepts[7].score	0.21013623476028442
concepts[7].wikidata	https://www.wikidata.org/wiki/Q48196
concepts[7].display_name	Stem cell
concepts[8].id	https://openalex.org/C41008148
concepts[8].level	0
concepts[8].score	0.12136375904083252
concepts[8].wikidata	https://www.wikidata.org/wiki/Q21198
concepts[8].display_name	Computer science
concepts[9].id	https://openalex.org/C109159458
concepts[9].level	3
concepts[9].score	0.0
concepts[9].wikidata	https://www.wikidata.org/wiki/Q919283
concepts[9].display_name	Haematopoiesis
concepts[10].id	https://openalex.org/C199360897
concepts[10].level	1
concepts[10].score	0.0
concepts[10].wikidata	https://www.wikidata.org/wiki/Q9143
concepts[10].display_name	Programming language
keywords[0].id	https://openalex.org/keywords/runx1
keywords[0].score	0.579426646232605
keywords[0].display_name	RUNX1
keywords[1].id	https://openalex.org/keywords/cell-growth
keywords[1].score	0.5605350732803345
keywords[1].display_name	Cell growth
keywords[2].id	https://openalex.org/keywords/expression
keywords[2].score	0.44308382272720337
keywords[2].display_name	Expression (computer science)
keywords[3].id	https://openalex.org/keywords/cell-biology
keywords[3].score	0.4397045969963074
keywords[3].display_name	Cell biology
keywords[4].id	https://openalex.org/keywords/cancer-research
keywords[4].score	0.3957812488079071
keywords[4].display_name	Cancer research
keywords[5].id	https://openalex.org/keywords/biology
keywords[5].score	0.36080703139305115
keywords[5].display_name	Biology
keywords[6].id	https://openalex.org/keywords/genetics
keywords[6].score	0.22121691703796387
keywords[6].display_name	Genetics
keywords[7].id	https://openalex.org/keywords/stem-cell
keywords[7].score	0.21013623476028442
keywords[7].display_name	Stem cell
keywords[8].id	https://openalex.org/keywords/computer-science
keywords[8].score	0.12136375904083252
keywords[8].display_name	Computer science
language	en
locations[0].id	pmh:oai:figshare.com:article/4816420
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4306400572
locations[0].source.issn
locations[0].source.type	repository
locations[0].source.is_oa	False
locations[0].source.issn_l
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	OPAL (Open@LaTrobe) (La Trobe University)
locations[0].source.host_organization	https://openalex.org/I196829312
locations[0].source.host_organization_name	La Trobe University
locations[0].source.host_organization_lineage	https://openalex.org/I196829312
locations[0].license	cc-by
locations[0].pdf_url
locations[0].version	submittedVersion
locations[0].raw_type	Image
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	False
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://figshare.com/articles/figure/LRG1_promoted_the_expression_of_RUNX1_and_CRC_cell_proliferation_/4816420
authorships[0].author.id	https://openalex.org/A5101812752
authorships[0].author.orcid	https://orcid.org/0009-0000-8838-0463
authorships[0].author.display_name	Zhou Ying
authorships[0].author_position	first
authorships[0].raw_author_name	Zhou Ying
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5011270379
authorships[1].author.orcid	https://orcid.org/0000-0002-5991-7919
authorships[1].author.display_name	Xintian Zhang
authorships[1].author_position	middle
authorships[1].raw_author_name	Zhang Xintian
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5100369399
authorships[2].author.orcid	https://orcid.org/0000-0002-7953-1159
authorships[2].author.display_name	Jingjing Zhang
authorships[2].author_position	middle
authorships[2].raw_author_name	Zhang Jingjing
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A5102739641
authorships[3].author.orcid
authorships[3].author.display_name	Fang Jingyuan
authorships[3].author_position	middle
authorships[3].raw_author_name	Fang Jingyuan
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A5012332270
authorships[4].author.orcid
authorships[4].author.display_name	Ge Zhizheng
authorships[4].author_position	middle
authorships[4].raw_author_name	Ge Zhizheng
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A5100318759
authorships[5].author.orcid	https://orcid.org/0000-0003-1037-3903
authorships[5].author.display_name	Xiaobo Li
authorships[5].author_position	last
authorships[5].raw_author_name	Li Xiaobo
authorships[5].is_corresponding	False
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://figshare.com/articles/figure/LRG1_promoted_the_expression_of_RUNX1_and_CRC_cell_proliferation_/4816420
open_access.oa_status	green
open_access.any_repository_has_fulltext	False
created_date	2019-10-10T00:00:00
display_name	LRG1 promoted the expression of RUNX1 and CRC cell proliferation.
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T14364
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9998000264167786
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2730
primary_topic.subfield.display_name	Oncology
primary_topic.display_name	Clusterin in disease pathology
related_works	https://openalex.org/W2604644186, https://openalex.org/W2605217619, https://openalex.org/W2530011614, https://openalex.org/W2902606484, https://openalex.org/W2898233117, https://openalex.org/W3043940750, https://openalex.org/W3004824434, https://openalex.org/W2460077718, https://openalex.org/W2606895347, https://openalex.org/W2884820590, https://openalex.org/W3095343134, https://openalex.org/W3205775954, https://openalex.org/W2902952542, https://openalex.org/W2903669968, https://openalex.org/W2939953894, https://openalex.org/W2914018802, https://openalex.org/W2945480548, https://openalex.org/W2912966838, https://openalex.org/W2913174563, https://openalex.org/W3044856686
cited_by_count	0
locations_count	1
best_oa_location.id	pmh:oai:figshare.com:article/4816420
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4306400572
best_oa_location.source.issn
best_oa_location.source.type	repository
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	OPAL (Open@LaTrobe) (La Trobe University)
best_oa_location.source.host_organization	https://openalex.org/I196829312
best_oa_location.source.host_organization_name	La Trobe University
best_oa_location.source.host_organization_lineage	https://openalex.org/I196829312
best_oa_location.license	cc-by
best_oa_location.pdf_url
best_oa_location.version	submittedVersion
best_oa_location.raw_type	Image
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	False
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://figshare.com/articles/figure/LRG1_promoted_the_expression_of_RUNX1_and_CRC_cell_proliferation_/4816420
primary_location.id	pmh:oai:figshare.com:article/4816420
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4306400572
primary_location.source.issn
primary_location.source.type	repository
primary_location.source.is_oa	False
primary_location.source.issn_l
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	OPAL (Open@LaTrobe) (La Trobe University)
primary_location.source.host_organization	https://openalex.org/I196829312
primary_location.source.host_organization_name	La Trobe University
primary_location.source.host_organization_lineage	https://openalex.org/I196829312
primary_location.license	cc-by
primary_location.pdf_url
primary_location.version	submittedVersion
primary_location.raw_type	Image
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	False
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://figshare.com/articles/figure/LRG1_promoted_the_expression_of_RUNX1_and_CRC_cell_proliferation_/4816420
publication_date	2017-04-05
publication_year	2017
referenced_works_count	0
abstract_inverted_index.a	49
abstract_inverted_index.24	30
abstract_inverted_index.B,	65
abstract_inverted_index.E,	66
abstract_inverted_index.as	98
abstract_inverted_index.by	19, 38, 82
abstract_inverted_index.h,	31
abstract_inverted_index.in	72, 77
abstract_inverted_index.of	13, 62, 90
abstract_inverted_index.to	54, 74
abstract_inverted_index.D1,	64
abstract_inverted_index.NC,	104
abstract_inverted_index.The	59
abstract_inverted_index.and	2, 10, 32, 48, 69, 93, 107
abstract_inverted_index.are	96
abstract_inverted_index.for	29
abstract_inverted_index.the	11, 14, 33, 94, 99
abstract_inverted_index.was	17, 36, 52
abstract_inverted_index.Bax,	68
abstract_inverted_index.LRG1	8, 75
abstract_inverted_index.This	85
abstract_inverted_index.cell	56
abstract_inverted_index.data	95
abstract_inverted_index.were	5, 23, 42, 80
abstract_inverted_index.with	7, 25, 44, 103
abstract_inverted_index.CCK-8	50
abstract_inverted_index.Cells	22, 41
abstract_inverted_index.RUNX1	34
abstract_inverted_index.RUNXs	16
abstract_inverted_index.SW480	1, 78
abstract_inverted_index.assay	51
abstract_inverted_index.blot.	84
abstract_inverted_index.cells	4, 79
abstract_inverted_index.rLRG1	26, 45
abstract_inverted_index.shows	87
abstract_inverted_index.Bcl-2,	67
abstract_inverted_index.HCT116	3
abstract_inverted_index.cyclin	63
abstract_inverted_index.figure	86
abstract_inverted_index.images	89
abstract_inverted_index.levels	61
abstract_inverted_index.ng/ml)	28
abstract_inverted_index.siRNA,	9
abstract_inverted_index.tested	15
abstract_inverted_index.RT-PCR.	20, 39
abstract_inverted_index.Western	83
abstract_inverted_index.cleaved	70
abstract_inverted_index.ng/ml),	47
abstract_inverted_index.protein	60
abstract_inverted_index.Compared	102
abstract_inverted_index.analysed	81
abstract_inverted_index.evaluate	55
abstract_inverted_index.repeated	91
abstract_inverted_index.response	73
abstract_inverted_index.(0–1000	46
abstract_inverted_index.caspase-3	71
abstract_inverted_index.performed	53
abstract_inverted_index.presented	97
abstract_inverted_index.treatment	76
abstract_inverted_index.(0–1,000	27
abstract_inverted_index.determined	37
abstract_inverted_index.deviation.	101
abstract_inverted_index.expression	12, 35
abstract_inverted_index.quantified	18
abstract_inverted_index.stimulated	24, 43
abstract_inverted_index.*P<0.05,	105
abstract_inverted_index.**P<0.01,	106
abstract_inverted_index.experiments,	92
abstract_inverted_index.transfection	6
abstract_inverted_index.mean±standard	100
abstract_inverted_index.proliferation.	57
abstract_inverted_index.representative	88
abstract_inverted_index.(<b>b)</b>	21
abstract_inverted_index.(<b>c)</b>	40
abstract_inverted_index.(<b>d)</b>	58
abstract_inverted_index.***P<0.001.</p>	108
abstract_inverted_index.<p><b>(a)</b>	0
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	6
sustainable_development_goals[0].id	https://metadata.un.org/sdg/2
sustainable_development_goals[0].score	0.6200000047683716
sustainable_development_goals[0].display_name	Zero hunger
citation_normalized_percentile