<i>Spirulina platensis</i> and its ingredient biopterin glucoside improved insulin sensitivity in non-alcoholic steatohepatitis model Article Swipe
Yuri Fujihara
,
Yasumasa Kodo
,
Shin-ichi Miyoshi
,
Ritsuko Watanabe
,
Hiroshi Toyoda
,
Mitsumasa Mankura
,
Hideaki Kabuto
,
Fusako Takayama
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3164/jcbn.20-201
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3164/jcbn.20-201
Non-alcoholic steatohepatitis is the chronic liver disease leading to cirrhosis and cancer and its prevalence is increasing. Some agents are under clinical trials for non-alcoholic steatohepatitis treatment. We previously reported Spirulina (Arthrospira) platensis effectively prevented non-alcoholic steatohepatitis progression in our model rats. The contribution of phycocyanin, an ingredient of Spirulina (Arthrospira) platensis, was limited. We, therefore, have looked for more active components of Spirulina (Arthrospira) platensis. In this study, we pursued the effect of biopterin glucoside, another bioactive ingredient of Spirulina (Arthrospira) platensis. We found Spirulina (Arthrospira) platensis and biopterin glucoside oral administrations effectively alleviated oxidative stress, inflammation and insulin signal failure, and prevented fibroblast growth factor 21 gene overexpression in non-alcoholic steatohepatitis rat livers. We concluded biopterin glucoside is a major component of Spirulina (Arthrospira) platensis action.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3164/jcbn.20-201
- https://www.jstage.jst.go.jp/article/jcbn/69/2/69_20-201/_pdf
- OA Status
- diamond
- Cited By
- 1
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3138580025
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3138580025Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3164/jcbn.20-201Digital Object Identifier
- Title
-
<i>Spirulina platensis</i> and its ingredient biopterin glucoside improved insulin sensitivity in non-alcoholic steatohepatitis modelWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-01-01Full publication date if available
- Authors
-
Yuri Fujihara, Yasumasa Kodo, Shin-ichi Miyoshi, Ritsuko Watanabe, Hiroshi Toyoda, Mitsumasa Mankura, Hideaki Kabuto, Fusako TakayamaList of authors in order
- Landing page
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https://doi.org/10.3164/jcbn.20-201Publisher landing page
- PDF URL
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https://www.jstage.jst.go.jp/article/jcbn/69/2/69_20-201/_pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://www.jstage.jst.go.jp/article/jcbn/69/2/69_20-201/_pdfDirect OA link when available
- Concepts
-
Spirulina (dietary supplement), Steatohepatitis, Arthrospira, Ingredient, Fatty liver, Food science, Chemistry, Medicine, Biology, Internal medicine, Cyanobacteria, Disease, Bacteria, Organic chemistry, Raw material, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1Per-year citation counts (last 5 years)
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40Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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