LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent Article Swipe
Daniela Puzzo
,
Roberto Piacentini
,
Mauro Fà
,
Walter Gulisano
,
Domenica Donatella Li Puma
,
Agnes Staniszewski
,
Hong Zhang
,
Maria Rosaria Tropea
,
Sara Cocco
,
Agostino Palmeri
,
Paul E. Fraser
,
Luciano D'adamio
,
Claudio Grassi
,
Ottavio Arancio
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.7554/elife.26991
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.7554/elife.26991
The concurrent application of subtoxic doses of soluble oligomeric forms of human amyloid-beta (oAβ) and Tau (oTau) proteins impairs memory and its electrophysiological surrogate long-term potentiation (LTP), effects that may be mediated by intra-neuronal oligomers uptake. Intrigued by these findings, we investigated whether oAβ and oTau share a common mechanism when they impair memory and LTP in mice. We found that as already shown for oAβ, also oTau can bind to amyloid precursor protein (APP). Moreover, efficient intra-neuronal uptake of oAβ and oTau requires expression of APP. Finally, the toxic effect of both extracellular oAβ and oTau on memory and LTP is dependent upon APP since APP-KO mice were resistant to oAβ- and oTau-induced defects in spatial/associative memory and LTP. Thus, APP might serve as a common therapeutic target against Alzheimer's Disease (AD) and a host of other neurodegenerative diseases characterized by abnormal levels of Aβ and/or Tau.
Related Topics
Concepts
Long-term potentiation
Extracellular
Neuroscience
Amyloid precursor protein
Amyloid (mycology)
Amyloid beta
Chemistry
Amyloid precursor protein secretase
Alzheimer's disease
Memory impairment
Cell biology
Biology
Biochemistry
Medicine
Disease
Internal medicine
Cognition
Receptor
Peptide
Inorganic chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.26991
- OA Status
- gold
- Cited By
- 176
- References
- 71
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2735082025
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2735082025Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.7554/elife.26991Digital Object Identifier
- Title
-
LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependentWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-07-11Full publication date if available
- Authors
-
Daniela Puzzo, Roberto Piacentini, Mauro Fà, Walter Gulisano, Domenica Donatella Li Puma, Agnes Staniszewski, Hong Zhang, Maria Rosaria Tropea, Sara Cocco, Agostino Palmeri, Paul E. Fraser, Luciano D'adamio, Claudio Grassi, Ottavio ArancioList of authors in order
- Landing page
-
https://doi.org/10.7554/elife.26991Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.7554/elife.26991Direct OA link when available
- Concepts
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Long-term potentiation, Extracellular, Neuroscience, Amyloid precursor protein, Amyloid (mycology), Amyloid beta, Chemistry, Amyloid precursor protein secretase, Alzheimer's disease, Memory impairment, Cell biology, Biology, Biochemistry, Medicine, Disease, Internal medicine, Cognition, Receptor, Peptide, Inorganic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
176Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 17, 2024: 36, 2023: 23, 2022: 14, 2021: 21Per-year citation counts (last 5 years)
- References (count)
-
71Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.APP | 104, 121 |
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