Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteers Article Swipe
Takayuki Kato
,
Yasushi Honda
,
Yusuke Kurita
,
Akito Iwasaki
,
Takamitsu Sato
,
Takaomi Kessoku
,
Shiori Uchiyama
,
Yuji Ogawa
,
Hidenori Ohkubo
,
Takuma Higurashi
,
Takeharu Yamanaka
,
Haruki Usuda
,
Koichiro Wada
,
Atsushi Nakajima
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0175626
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0175626
This study is the first to report an improvement in leaky gut using an available drug in humans. The result suggests that lubiprostone may prevent and ameliorate "leaky gut syndrome". However, a pivotal trial is needed to confirm our finding.
Related Topics
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0175626
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0175626&type=printable
- OA Status
- gold
- Cited By
- 48
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2605530173
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2605530173Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pone.0175626Digital Object Identifier
- Title
-
Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteersWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-04-14Full publication date if available
- Authors
-
Takayuki Kato, Yasushi Honda, Yusuke Kurita, Akito Iwasaki, Takamitsu Sato, Takaomi Kessoku, Shiori Uchiyama, Yuji Ogawa, Hidenori Ohkubo, Takuma Higurashi, Takeharu Yamanaka, Haruki Usuda, Koichiro Wada, Atsushi NakajimaList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pone.0175626Publisher landing page
- PDF URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0175626&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0175626&type=printableDirect OA link when available
- Concepts
-
Lubiprostone, Medicine, Intestinal permeability, Randomized controlled trial, Prospective cohort study, Internal medicine, Constipation, Chronic constipationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
48Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 3, 2023: 9, 2022: 10, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
32Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works_count | 32 |
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| corresponding_author_ids | https://openalex.org/A5047344052, https://openalex.org/A5102976874, https://openalex.org/A5102567624, https://openalex.org/A5002514925, https://openalex.org/A5003859363, https://openalex.org/A5071808903, https://openalex.org/A5020589711, https://openalex.org/A5008918211, https://openalex.org/A5003648443, https://openalex.org/A5104339507, https://openalex.org/A5112186760, https://openalex.org/A5026289585, https://openalex.org/A5068805568, https://openalex.org/A5108560087 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 14 |
| corresponding_institution_ids | https://openalex.org/I169016828, https://openalex.org/I89630735 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8500000238418579 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.91693474 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |