Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy. Article Swipe
Therése Klingstedt
,
Bernardino Ghetti
,
Janice L. Holton
,
Helen Ling
,
K. Peter R. Nilsson
,
Michel Goedert
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.17863/cam.47543
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.17863/cam.47543
Synucleinopathies [Parkinson's disease with or without dementia, dementia with Lewy bodies and multiple system atrophy] are neurodegenerative diseases that are defined by the presence of filamentous α-synuclein inclusions. We investigated the ability of luminescent conjugated oligothiophenes to stain the inclusions of Parkinson's disease and multiple system atrophy. They stained the Lewy pathology of Parkinson's disease and the glial cytoplasmic inclusions of multiple system atrophy. Spectral analysis of HS-68-stained inclusions showed a red shift in multiple system atrophy, but the difference with Parkinson's disease was not significant. However, when inclusions were double-labelled for HS-68 and an antibody specific for α-synuclein phosphorylated at S129, they could be distinguished based on colour shifts with blue designated for Parkinson's disease and red for multiple system atrophy. The inclusions of Parkinson's disease and multiple system atrophy could also be distinguished using fluorescence lifetime imaging. These findings are consistent with the presence of distinct conformers of assembled α-synuclein in Parkinson's disease and multiple system atrophy.
Related Topics
Concepts
Atrophy
Dementia with Lewy bodies
Parkinson's disease
Synucleinopathies
Pathology
Cytoplasmic inclusion
Dementia
Lewy body
Alpha-synuclein
Medicine
Disease
Chemistry
Biochemistry
Cytoplasm
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://www.repository.cam.ac.uk/handle/1810/300471
- OA Status
- green
- Related Works
- 20
- OpenAlex ID
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All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W3000263300Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.17863/cam.47543Digital Object Identifier
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Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy.Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
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2019-12-03Full publication date if available
- Authors
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Therése Klingstedt, Bernardino Ghetti, Janice L. Holton, Helen Ling, K. Peter R. Nilsson, Michel GoedertList of authors in order
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https://www.repository.cam.ac.uk/handle/1810/300471Publisher landing page
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.repository.cam.ac.uk/handle/1810/300471Direct OA link when available
- Concepts
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Atrophy, Dementia with Lewy bodies, Parkinson's disease, Synucleinopathies, Pathology, Cytoplasmic inclusion, Dementia, Lewy body, Alpha-synuclein, Medicine, Disease, Chemistry, Biochemistry, CytoplasmTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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20Other works algorithmically related by OpenAlex
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