Lung Delivery of Lactose-Free Microparticles Loaded with Azithromycin for the Treatment of Bacterial Infections Article Swipe
Gracia Molina
,
Dolores R. Serrano
,
María Auxiliadora Dea‐Ayuela
,
Carmina Rodríguez Fernández
,
Elena González‐Burgos
,
Brayan J. Anaya
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics17060770
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics17060770
Background/Objectives: Respiratory bacterial infections remain a significant global health challenge, with effective drug delivery to the lungs being crucial for successful treatment. This study aimed to develop a lactose-free dry powder inhaler (DPI) formulation containing azithromycin (AZM) microparticles for enhanced pulmonary delivery. Methods: Using a quality-by-design approach, an optimized formulation (4% AZM, 20% leucine, and 76% mannitol) was achieved. Results: The formulation demonstrated excellent aerodynamic properties with a mass median aerodynamic diameter (MMAD) of 2.72 μm ± 0.01 μm and fine particle fraction (FPF) (<5 μm) of 65.42% ± 5.12%. AZM-loaded microparticles exhibited enhanced efficacy against Pseudomonas aeruginosa with a two-fold reduction in the minimum bactericidal concentration (7.81 μg/mL vs. 15.62 μg/mL) compared to unprocessed AZM, while maintaining activity against Streptococcus pneumoniae. AZM microparticles demonstrated good biocompatibility with red blood cells and bronchial epithelial cells at therapeutic concentrations. Conclusions: These findings establish a promising lactose-free antibiotic formulation for targeted pulmonary delivery with enhanced antimicrobial efficacy.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/pharmaceutics17060770
- https://www.mdpi.com/1999-4923/17/6/770/pdf?version=1749643930
- OA Status
- gold
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411211138
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4411211138Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/pharmaceutics17060770Digital Object Identifier
- Title
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Lung Delivery of Lactose-Free Microparticles Loaded with Azithromycin for the Treatment of Bacterial InfectionsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-06-11Full publication date if available
- Authors
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Gracia Molina, Dolores R. Serrano, María Auxiliadora Dea‐Ayuela, Carmina Rodríguez Fernández, Elena González‐Burgos, Brayan J. AnayaList of authors in order
- Landing page
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https://doi.org/10.3390/pharmaceutics17060770Publisher landing page
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https://www.mdpi.com/1999-4923/17/6/770/pdf?version=1749643930Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1999-4923/17/6/770/pdf?version=1749643930Direct OA link when available
- Concepts
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Azithromycin, Lung, Lactose, Medicine, Microbiology, Chemistry, Antibiotics, Biology, Internal medicine, Food scienceTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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49Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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