Lung tumor-infiltrating T_reghave divergent transcriptional profiles and function linked to checkpoint blockade response Article Swipe

PDF

Arbor G. Dykema , Jiajia Zhang , Boyang Zhang , Laurene S. Cheung , Zhen Zeng , Christopher Cherry , Taibo Li , Justina X. Caushi , Marni Nishimoto , Sydney Connor , Zhicheng Ji , Andrew J. Munoz , Wenpin Hou , Wentao Zhan , Dipika Singh , Rufiaat Rashid , Marisa Mitchell-Flack , Sadhana Bom , Ada Tam , Nick Ionta , Yi Wang , Camille A. Sawosik , Lauren E. Tirado , Luke M. Tomasovic , Derek VanDyke , Jamie B. Spangler , Valsamo Anagnostou , Stephen C. Yang , Jonathan Spicer , Roni Rayes , Janis M. Taube , Julie R. Brahmer , Patrick M. Forde , Srinivasan Yegnasubramanian , Hongkai Ji , Drew M. Pardoll , Kellie N. Smith ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.1101/2022.12.13.520329

Regulatory T cells (T reg ) are conventionally viewed to suppress endogenous and therapyinduced anti-tumor immunity; however, their role in modulating responses to immune checkpoint blockade (ICB) is unclear. In this study, we integrated single-cell RNAseq/TCRseq of >73,000 tumor-infiltrating T reg (TIL-T reg ) from anti-PD-1-treated and treatment naive non-small cell lung cancers (NSCLC) with single cell analysis of tumor-associated antigen (TAA)-specific T reg derived from a murine tumor model. We identified 10 subsets of human TIL-T reg , most of which have high concordance with murine TIL-T reg subsets. Notably, one subset selectively expresses high levels of OX40 and GITR, whose engangement by cognate ligand mediated proliferative programs and NF-kB activation, as well as multiple genes involved in T reg suppression, in particular LAG3. Functionally, the OX40 hi GITR hi subset in the most highly suppressive ex vivo and T reg expression of OX40, GITR and LAG3, correlated with resistance to PD-1 blockade. Surprisingly, in the murine tumor model, we found that virtually all TIL-T reg expressing T cell receptors that are specific for TAA fully develop a distinct Th1-like signature over a two-week period after entry into the tumor, down-regulating FoxP3 and up-regulating expression of TBX21 ( Tbet), IFNγ and certain pro-inflammatory granzymes. Application of a gene score from the murine TAA-specific Th1-like T reg subset to the human single-cell dataset revealed a highly analogous subcluster that was enriched in anti-PD-1 responding tumors. These findings demonstrate that TIL-T reg partition into multiple distinct transcriptionally-defined subsets with potentially opposing effects on ICB-induced anti-tumor immunity and suggest that TAA-specific TIL-T reg may positively contribute to anti-tumor responses. One-Sentence Summary We define 10 subsets of lung cancer-infiltrating regulatory T cells, one of which is highly suppressive and enriched in anti-PD-1 non-responders and the other is Th1-like and is enriched in PD-1 responders.

Related Topics

Concepts

FOXP3 Cancer research T cell Immune checkpoint Biology Tumor-infiltrating lymphocytes Blockade Immune system Tumor microenvironment Immunotherapy Immunology Receptor Genetics

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.1101/2022.12.13.520329
PDF: https://www.biorxiv.org/content/biorxiv/early/2022/12/15/2022.12.13.520329.full.pdf
OA Status: green
References: 77
Related Works: 10
OpenAlex ID: https://openalex.org/W4311820175

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4311820175

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1101/2022.12.13.520329

Digital Object Identifier
Title: Lung tumor-infiltrating T_reghave divergent transcriptional profiles and function linked to checkpoint blockade response

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2022

Year of publication
Publication date: 2022-12-15

Full publication date if available
Authors: Arbor G. Dykema, Jiajia Zhang, Boyang Zhang, Laurene S. Cheung, Zhen Zeng, Christopher Cherry, Taibo Li, Justina X. Caushi, Marni Nishimoto, Sydney Connor, Zhicheng Ji, Andrew J. Munoz, Wenpin Hou, Wentao Zhan, Dipika Singh, Rufiaat Rashid, Marisa Mitchell-Flack, Sadhana Bom, Ada Tam, Nick Ionta, Yi Wang, Camille A. Sawosik, Lauren E. Tirado, Luke M. Tomasovic, Derek VanDyke, Jamie B. Spangler, Valsamo Anagnostou, Stephen C. Yang, Jonathan Spicer, Roni Rayes, Janis M. Taube, Julie R. Brahmer, Patrick M. Forde, Srinivasan Yegnasubramanian, Hongkai Ji, Drew M. Pardoll, Kellie N. Smith

List of authors in order
Landing page: https://doi.org/10.1101/2022.12.13.520329

Publisher landing page
PDF URL: https://www.biorxiv.org/content/biorxiv/early/2022/12/15/2022.12.13.520329.full.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: green

Open access status per OpenAlex
OA URL: https://www.biorxiv.org/content/biorxiv/early/2022/12/15/2022.12.13.520329.full.pdf

Direct OA link when available
Concepts: FOXP3, Cancer research, T cell, Immune checkpoint, Biology, Tumor-infiltrating lymphocytes, Blockade, Immune system, Tumor microenvironment, Immunotherapy, Immunology, Receptor, Genetics

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
References (count): 77

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4311820175
doi	https://doi.org/10.1101/2022.12.13.520329
ids.doi	https://doi.org/10.1101/2022.12.13.520329
ids.openalex	https://openalex.org/W4311820175
fwci	0.0
type	preprint
title	Lung tumor-infiltrating T_reghave divergent transcriptional profiles and function linked to checkpoint blockade response
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T10158
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9997000098228455
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2730
topics[0].subfield.display_name	Oncology
topics[0].display_name	Cancer Immunotherapy and Biomarkers
topics[1].id	https://openalex.org/T11491
topics[1].field.id	https://openalex.org/fields/27
topics[1].field.display_name	Medicine
topics[1].score	0.9995999932289124
topics[1].domain.id	https://openalex.org/domains/4
topics[1].domain.display_name	Health Sciences
topics[1].subfield.id	https://openalex.org/subfields/2730
topics[1].subfield.display_name	Oncology
topics[1].display_name	CAR-T cell therapy research
topics[2].id	https://openalex.org/T10580
topics[2].field.id	https://openalex.org/fields/24
topics[2].field.display_name	Immunology and Microbiology
topics[2].score	0.9995999932289124
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/2403
topics[2].subfield.display_name	Immunology
topics[2].display_name	Immunotherapy and Immune Responses
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2779727006
concepts[0].level	3
concepts[0].score	0.6064683794975281
concepts[0].wikidata	https://www.wikidata.org/wiki/Q426188
concepts[0].display_name	FOXP3
concepts[1].id	https://openalex.org/C502942594
concepts[1].level	1
concepts[1].score	0.5798242688179016
concepts[1].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[1].display_name	Cancer research
concepts[2].id	https://openalex.org/C2776090121
concepts[2].level	3
concepts[2].score	0.5788371562957764
concepts[2].wikidata	https://www.wikidata.org/wiki/Q193529
concepts[2].display_name	T cell
concepts[3].id	https://openalex.org/C2780851360
concepts[3].level	4
concepts[3].score	0.5631996393203735
concepts[3].wikidata	https://www.wikidata.org/wiki/Q21686041
concepts[3].display_name	Immune checkpoint
concepts[4].id	https://openalex.org/C86803240
concepts[4].level	0
concepts[4].score	0.5507423281669617
concepts[4].wikidata	https://www.wikidata.org/wiki/Q420
concepts[4].display_name	Biology
concepts[5].id	https://openalex.org/C2778326572
concepts[5].level	4
concepts[5].score	0.4884616434574127
concepts[5].wikidata	https://www.wikidata.org/wiki/Q7852668
concepts[5].display_name	Tumor-infiltrating lymphocytes
concepts[6].id	https://openalex.org/C2778468042
concepts[6].level	3
concepts[6].score	0.4568934440612793
concepts[6].wikidata	https://www.wikidata.org/wiki/Q273976
concepts[6].display_name	Blockade
concepts[7].id	https://openalex.org/C8891405
concepts[7].level	2
concepts[7].score	0.4547204375267029
concepts[7].wikidata	https://www.wikidata.org/wiki/Q1059
concepts[7].display_name	Immune system
concepts[8].id	https://openalex.org/C2776107976
concepts[8].level	3
concepts[8].score	0.4277169704437256
concepts[8].wikidata	https://www.wikidata.org/wiki/Q1786433
concepts[8].display_name	Tumor microenvironment
concepts[9].id	https://openalex.org/C2777701055
concepts[9].level	3
concepts[9].score	0.40062981843948364
concepts[9].wikidata	https://www.wikidata.org/wiki/Q1427096
concepts[9].display_name	Immunotherapy
concepts[10].id	https://openalex.org/C203014093
concepts[10].level	1
concepts[10].score	0.3970022201538086
concepts[10].wikidata	https://www.wikidata.org/wiki/Q101929
concepts[10].display_name	Immunology
concepts[11].id	https://openalex.org/C170493617
concepts[11].level	2
concepts[11].score	0.2620602250099182
concepts[11].wikidata	https://www.wikidata.org/wiki/Q208467
concepts[11].display_name	Receptor
concepts[12].id	https://openalex.org/C54355233
concepts[12].level	1
concepts[12].score	0.06727010011672974
concepts[12].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[12].display_name	Genetics
keywords[0].id	https://openalex.org/keywords/foxp3
keywords[0].score	0.6064683794975281
keywords[0].display_name	FOXP3
keywords[1].id	https://openalex.org/keywords/cancer-research
keywords[1].score	0.5798242688179016
keywords[1].display_name	Cancer research
keywords[2].id	https://openalex.org/keywords/t-cell
keywords[2].score	0.5788371562957764
keywords[2].display_name	T cell
keywords[3].id	https://openalex.org/keywords/immune-checkpoint
keywords[3].score	0.5631996393203735
keywords[3].display_name	Immune checkpoint
keywords[4].id	https://openalex.org/keywords/biology
keywords[4].score	0.5507423281669617
keywords[4].display_name	Biology
keywords[5].id	https://openalex.org/keywords/tumor-infiltrating-lymphocytes
keywords[5].score	0.4884616434574127
keywords[5].display_name	Tumor-infiltrating lymphocytes
keywords[6].id	https://openalex.org/keywords/blockade
keywords[6].score	0.4568934440612793
keywords[6].display_name	Blockade
keywords[7].id	https://openalex.org/keywords/immune-system
keywords[7].score	0.4547204375267029
keywords[7].display_name	Immune system
keywords[8].id	https://openalex.org/keywords/tumor-microenvironment
keywords[8].score	0.4277169704437256
keywords[8].display_name	Tumor microenvironment
keywords[9].id	https://openalex.org/keywords/immunotherapy
keywords[9].score	0.40062981843948364
keywords[9].display_name	Immunotherapy
keywords[10].id	https://openalex.org/keywords/immunology
keywords[10].score	0.3970022201538086
keywords[10].display_name	Immunology
keywords[11].id	https://openalex.org/keywords/receptor
keywords[11].score	0.2620602250099182
keywords[11].display_name	Receptor
keywords[12].id	https://openalex.org/keywords/genetics
keywords[12].score	0.06727010011672974
keywords[12].display_name	Genetics
language	en
locations[0].id	doi:10.1101/2022.12.13.520329
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4306402567
locations[0].source.issn
locations[0].source.type	repository
locations[0].source.is_oa	False
locations[0].source.issn_l
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
locations[0].source.host_organization	https://openalex.org/I2750212522
locations[0].source.host_organization_name	Cold Spring Harbor Laboratory
locations[0].source.host_organization_lineage	https://openalex.org/I2750212522
locations[0].license	cc-by-nc
locations[0].pdf_url	https://www.biorxiv.org/content/biorxiv/early/2022/12/15/2022.12.13.520329.full.pdf
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by-nc
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1101/2022.12.13.520329
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5035749052
authorships[0].author.orcid	https://orcid.org/0000-0001-5835-3261
authorships[0].author.display_name	Arbor G. Dykema
authorships[0].countries	US
authorships[0].affiliations[0].institution_ids	https://openalex.org/I1299907687
authorships[0].affiliations[0].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[0].affiliations[1].institution_ids	https://openalex.org/I4210164401
authorships[0].affiliations[1].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[0].affiliations[2].institution_ids	https://openalex.org/I2802640032
authorships[0].affiliations[2].raw_affiliation_string	The Mark Foundation Center for Advanced Genomics and Imaging, Baltimore, MD, USA
authorships[0].institutions[0].id	https://openalex.org/I1299907687
authorships[0].institutions[0].ror	https://ror.org/02rdpzb15
authorships[0].institutions[0].type	company
authorships[0].institutions[0].lineage	https://openalex.org/I1299907687
authorships[0].institutions[0].country_code	US
authorships[0].institutions[0].display_name	Bloomberg (United States)
authorships[0].institutions[1].id	https://openalex.org/I2802640032
authorships[0].institutions[1].ror	https://ror.org/0377f6951
authorships[0].institutions[1].type	nonprofit
authorships[0].institutions[1].lineage	https://openalex.org/I2802640032
authorships[0].institutions[1].country_code	US
authorships[0].institutions[1].display_name	Foundation Center
authorships[0].institutions[2].id	https://openalex.org/I4210164401
authorships[0].institutions[2].ror	https://ror.org/05m5b8x20
authorships[0].institutions[2].type	facility
authorships[0].institutions[2].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[0].institutions[2].country_code	US
authorships[0].institutions[2].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[0].author_position	first
authorships[0].raw_author_name	Arbor G. Dykema
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA, The Mark Foundation Center for Advanced Genomics and Imaging, Baltimore, MD, USA
authorships[1].author.id	https://openalex.org/A5100417650
authorships[1].author.orcid	https://orcid.org/0000-0003-4623-6134
authorships[1].author.display_name	Jiajia Zhang
authorships[1].countries	US
authorships[1].affiliations[0].institution_ids	https://openalex.org/I2802640032
authorships[1].affiliations[0].raw_affiliation_string	The Mark Foundation Center for Advanced Genomics and Imaging, Baltimore, MD, USA
authorships[1].affiliations[1].institution_ids	https://openalex.org/I4210164401
authorships[1].affiliations[1].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[1].affiliations[2].institution_ids	https://openalex.org/I1299907687
authorships[1].affiliations[2].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[1].institutions[0].id	https://openalex.org/I1299907687
authorships[1].institutions[0].ror	https://ror.org/02rdpzb15
authorships[1].institutions[0].type	company
authorships[1].institutions[0].lineage	https://openalex.org/I1299907687
authorships[1].institutions[0].country_code	US
authorships[1].institutions[0].display_name	Bloomberg (United States)
authorships[1].institutions[1].id	https://openalex.org/I2802640032
authorships[1].institutions[1].ror	https://ror.org/0377f6951
authorships[1].institutions[1].type	nonprofit
authorships[1].institutions[1].lineage	https://openalex.org/I2802640032
authorships[1].institutions[1].country_code	US
authorships[1].institutions[1].display_name	Foundation Center
authorships[1].institutions[2].id	https://openalex.org/I4210164401
authorships[1].institutions[2].ror	https://ror.org/05m5b8x20
authorships[1].institutions[2].type	facility
authorships[1].institutions[2].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[1].institutions[2].country_code	US
authorships[1].institutions[2].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[1].author_position	middle
authorships[1].raw_author_name	Jiajia Zhang
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA, The Mark Foundation Center for Advanced Genomics and Imaging, Baltimore, MD, USA
authorships[2].author.id	https://openalex.org/A5100677422
authorships[2].author.orcid	https://orcid.org/0000-0002-0895-6002
authorships[2].author.display_name	Boyang Zhang
authorships[2].countries	US
authorships[2].affiliations[0].institution_ids	https://openalex.org/I145311948
authorships[2].affiliations[0].raw_affiliation_string	Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
authorships[2].affiliations[1].institution_ids	https://openalex.org/I6059380
authorships[2].affiliations[1].raw_affiliation_string	Baltimore, MD, USA
authorships[2].institutions[0].id	https://openalex.org/I145311948
authorships[2].institutions[0].ror	https://ror.org/00za53h95
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I145311948
authorships[2].institutions[0].country_code	US
authorships[2].institutions[0].display_name	Johns Hopkins University
authorships[2].institutions[1].id	https://openalex.org/I6059380
authorships[2].institutions[1].ror	https://ror.org/024gw2733
authorships[2].institutions[1].type	education
authorships[2].institutions[1].lineage	https://openalex.org/I6059380
authorships[2].institutions[1].country_code	US
authorships[2].institutions[1].display_name	University of Baltimore
authorships[2].author_position	middle
authorships[2].raw_author_name	Boyang Zhang
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Baltimore, MD, USA, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
authorships[3].author.id	https://openalex.org/A5072971770
authorships[3].author.orcid	https://orcid.org/0000-0002-5759-9742
authorships[3].author.display_name	Laurene S. Cheung
authorships[3].countries	US
authorships[3].affiliations[0].institution_ids	https://openalex.org/I4210164401
authorships[3].affiliations[0].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[3].affiliations[1].institution_ids	https://openalex.org/I1299907687
authorships[3].affiliations[1].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[3].institutions[0].id	https://openalex.org/I1299907687
authorships[3].institutions[0].ror	https://ror.org/02rdpzb15
authorships[3].institutions[0].type	company
authorships[3].institutions[0].lineage	https://openalex.org/I1299907687
authorships[3].institutions[0].country_code	US
authorships[3].institutions[0].display_name	Bloomberg (United States)
authorships[3].institutions[1].id	https://openalex.org/I4210164401
authorships[3].institutions[1].ror	https://ror.org/05m5b8x20
authorships[3].institutions[1].type	facility
authorships[3].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[3].institutions[1].country_code	US
authorships[3].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[3].author_position	middle
authorships[3].raw_author_name	Laurene S. Cheung
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[4].author.id	https://openalex.org/A5002937123
authorships[4].author.orcid	https://orcid.org/0000-0002-3443-0637
authorships[4].author.display_name	Zhen Zeng
authorships[4].countries	US
authorships[4].affiliations[0].institution_ids	https://openalex.org/I1299907687
authorships[4].affiliations[0].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[4].affiliations[1].institution_ids	https://openalex.org/I2802640032
authorships[4].affiliations[1].raw_affiliation_string	The Mark Foundation Center for Advanced Genomics and Imaging, Baltimore, MD, USA
authorships[4].affiliations[2].institution_ids	https://openalex.org/I4210164401
authorships[4].affiliations[2].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[4].institutions[0].id	https://openalex.org/I1299907687
authorships[4].institutions[0].ror	https://ror.org/02rdpzb15
authorships[4].institutions[0].type	company
authorships[4].institutions[0].lineage	https://openalex.org/I1299907687
authorships[4].institutions[0].country_code	US
authorships[4].institutions[0].display_name	Bloomberg (United States)
authorships[4].institutions[1].id	https://openalex.org/I2802640032
authorships[4].institutions[1].ror	https://ror.org/0377f6951
authorships[4].institutions[1].type	nonprofit
authorships[4].institutions[1].lineage	https://openalex.org/I2802640032
authorships[4].institutions[1].country_code	US
authorships[4].institutions[1].display_name	Foundation Center
authorships[4].institutions[2].id	https://openalex.org/I4210164401
authorships[4].institutions[2].ror	https://ror.org/05m5b8x20
authorships[4].institutions[2].type	facility
authorships[4].institutions[2].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[4].institutions[2].country_code	US
authorships[4].institutions[2].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[4].author_position	middle
authorships[4].raw_author_name	Zhen Zeng
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA, The Mark Foundation Center for Advanced Genomics and Imaging, Baltimore, MD, USA
authorships[5].author.id	https://openalex.org/A5076970480
authorships[5].author.orcid	https://orcid.org/0000-0002-5481-0055
authorships[5].author.display_name	Christopher Cherry
authorships[5].affiliations[0].raw_affiliation_string	CM Cherry Consulting, Baltimore, MD, USA
authorships[5].author_position	middle
authorships[5].raw_author_name	Christopher M. Cherry
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	CM Cherry Consulting, Baltimore, MD, USA
authorships[6].author.id	https://openalex.org/A5050296122
authorships[6].author.orcid	https://orcid.org/0000-0002-6624-9293
authorships[6].author.display_name	Taibo Li
authorships[6].countries	US
authorships[6].affiliations[0].institution_ids	https://openalex.org/I6059380
authorships[6].affiliations[0].raw_affiliation_string	Baltimore, MD, USA
authorships[6].affiliations[1].institution_ids	https://openalex.org/I145311948
authorships[6].affiliations[1].raw_affiliation_string	Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
authorships[6].institutions[0].id	https://openalex.org/I145311948
authorships[6].institutions[0].ror	https://ror.org/00za53h95
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I145311948
authorships[6].institutions[0].country_code	US
authorships[6].institutions[0].display_name	Johns Hopkins University
authorships[6].institutions[1].id	https://openalex.org/I6059380
authorships[6].institutions[1].ror	https://ror.org/024gw2733
authorships[6].institutions[1].type	education
authorships[6].institutions[1].lineage	https://openalex.org/I6059380
authorships[6].institutions[1].country_code	US
authorships[6].institutions[1].display_name	University of Baltimore
authorships[6].author_position	middle
authorships[6].raw_author_name	Taibo Li
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	Baltimore, MD, USA, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
authorships[7].author.id	https://openalex.org/A5085068204
authorships[7].author.orcid	https://orcid.org/0000-0002-8009-3408
authorships[7].author.display_name	Justina X. Caushi
authorships[7].countries	US
authorships[7].affiliations[0].institution_ids	https://openalex.org/I1299907687
authorships[7].affiliations[0].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[7].affiliations[1].institution_ids	https://openalex.org/I4210164401
authorships[7].affiliations[1].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[7].institutions[0].id	https://openalex.org/I1299907687
authorships[7].institutions[0].ror	https://ror.org/02rdpzb15
authorships[7].institutions[0].type	company
authorships[7].institutions[0].lineage	https://openalex.org/I1299907687
authorships[7].institutions[0].country_code	US
authorships[7].institutions[0].display_name	Bloomberg (United States)
authorships[7].institutions[1].id	https://openalex.org/I4210164401
authorships[7].institutions[1].ror	https://ror.org/05m5b8x20
authorships[7].institutions[1].type	facility
authorships[7].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[7].institutions[1].country_code	US
authorships[7].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[7].author_position	middle
authorships[7].raw_author_name	Justina X. Caushi
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[8].author.id	https://openalex.org/A5014690286
authorships[8].author.orcid	https://orcid.org/0000-0002-0696-579X
authorships[8].author.display_name	Marni Nishimoto
authorships[8].countries	US
authorships[8].affiliations[0].institution_ids	https://openalex.org/I1299907687
authorships[8].affiliations[0].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[8].affiliations[1].institution_ids	https://openalex.org/I4210164401
authorships[8].affiliations[1].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[8].institutions[0].id	https://openalex.org/I1299907687
authorships[8].institutions[0].ror	https://ror.org/02rdpzb15
authorships[8].institutions[0].type	company
authorships[8].institutions[0].lineage	https://openalex.org/I1299907687
authorships[8].institutions[0].country_code	US
authorships[8].institutions[0].display_name	Bloomberg (United States)
authorships[8].institutions[1].id	https://openalex.org/I4210164401
authorships[8].institutions[1].ror	https://ror.org/05m5b8x20
authorships[8].institutions[1].type	facility
authorships[8].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[8].institutions[1].country_code	US
authorships[8].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[8].author_position	middle
authorships[8].raw_author_name	Marni Nishimoto
authorships[8].is_corresponding	False
authorships[8].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[9].author.id	https://openalex.org/A5039974944
authorships[9].author.orcid	https://orcid.org/0000-0002-0692-8008
authorships[9].author.display_name	Sydney Connor
authorships[9].countries	US
authorships[9].affiliations[0].institution_ids	https://openalex.org/I4210164401
authorships[9].affiliations[0].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[9].affiliations[1].institution_ids	https://openalex.org/I1299907687
authorships[9].affiliations[1].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[9].institutions[0].id	https://openalex.org/I1299907687
authorships[9].institutions[0].ror	https://ror.org/02rdpzb15
authorships[9].institutions[0].type	company
authorships[9].institutions[0].lineage	https://openalex.org/I1299907687
authorships[9].institutions[0].country_code	US
authorships[9].institutions[0].display_name	Bloomberg (United States)
authorships[9].institutions[1].id	https://openalex.org/I4210164401
authorships[9].institutions[1].ror	https://ror.org/05m5b8x20
authorships[9].institutions[1].type	facility
authorships[9].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[9].institutions[1].country_code	US
authorships[9].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[9].author_position	middle
authorships[9].raw_author_name	Sydney Connor
authorships[9].is_corresponding	False
authorships[9].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[10].author.id	https://openalex.org/A5077329074
authorships[10].author.orcid	https://orcid.org/0000-0002-9457-4704
authorships[10].author.display_name	Zhicheng Ji
authorships[10].countries	US
authorships[10].affiliations[0].institution_ids	https://openalex.org/I170897317
authorships[10].affiliations[0].raw_affiliation_string	Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, 27710, USA
authorships[10].institutions[0].id	https://openalex.org/I170897317
authorships[10].institutions[0].ror	https://ror.org/00py81415
authorships[10].institutions[0].type	education
authorships[10].institutions[0].lineage	https://openalex.org/I170897317
authorships[10].institutions[0].country_code	US
authorships[10].institutions[0].display_name	Duke University
authorships[10].author_position	middle
authorships[10].raw_author_name	Zhicheng Ji
authorships[10].is_corresponding	False
authorships[10].raw_affiliation_strings	Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, 27710, USA
authorships[11].author.id	https://openalex.org/A5003328729
authorships[11].author.orcid	https://orcid.org/0000-0001-5118-1217
authorships[11].author.display_name	Andrew J. Munoz
authorships[11].countries	US
authorships[11].affiliations[0].institution_ids	https://openalex.org/I4210164401
authorships[11].affiliations[0].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[11].affiliations[1].institution_ids	https://openalex.org/I1299907687
authorships[11].affiliations[1].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[11].institutions[0].id	https://openalex.org/I1299907687
authorships[11].institutions[0].ror	https://ror.org/02rdpzb15
authorships[11].institutions[0].type	company
authorships[11].institutions[0].lineage	https://openalex.org/I1299907687
authorships[11].institutions[0].country_code	US
authorships[11].institutions[0].display_name	Bloomberg (United States)
authorships[11].institutions[1].id	https://openalex.org/I4210164401
authorships[11].institutions[1].ror	https://ror.org/05m5b8x20
authorships[11].institutions[1].type	facility
authorships[11].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[11].institutions[1].country_code	US
authorships[11].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[11].author_position	middle
authorships[11].raw_author_name	Andrew J. Munoz
authorships[11].is_corresponding	False
authorships[11].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[12].author.id	https://openalex.org/A5072013279
authorships[12].author.orcid	https://orcid.org/0000-0003-0972-2192
authorships[12].author.display_name	Wenpin Hou
authorships[12].countries	US
authorships[12].affiliations[0].institution_ids	https://openalex.org/I145311948
authorships[12].affiliations[0].raw_affiliation_string	Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
authorships[12].affiliations[1].institution_ids	https://openalex.org/I6059380
authorships[12].affiliations[1].raw_affiliation_string	Baltimore, MD, USA
authorships[12].institutions[0].id	https://openalex.org/I145311948
authorships[12].institutions[0].ror	https://ror.org/00za53h95
authorships[12].institutions[0].type	education
authorships[12].institutions[0].lineage	https://openalex.org/I145311948
authorships[12].institutions[0].country_code	US
authorships[12].institutions[0].display_name	Johns Hopkins University
authorships[12].institutions[1].id	https://openalex.org/I6059380
authorships[12].institutions[1].ror	https://ror.org/024gw2733
authorships[12].institutions[1].type	education
authorships[12].institutions[1].lineage	https://openalex.org/I6059380
authorships[12].institutions[1].country_code	US
authorships[12].institutions[1].display_name	University of Baltimore
authorships[12].author_position	middle
authorships[12].raw_author_name	Wenpin Hou
authorships[12].is_corresponding	False
authorships[12].raw_affiliation_strings	Baltimore, MD, USA, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
authorships[13].author.id	https://openalex.org/A5005170140
authorships[13].author.orcid	https://orcid.org/0000-0002-2615-7642
authorships[13].author.display_name	Wentao Zhan
authorships[13].countries	US
authorships[13].affiliations[0].institution_ids	https://openalex.org/I145311948
authorships[13].affiliations[0].raw_affiliation_string	Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
authorships[13].affiliations[1].institution_ids	https://openalex.org/I6059380
authorships[13].affiliations[1].raw_affiliation_string	Baltimore, MD, USA
authorships[13].institutions[0].id	https://openalex.org/I145311948
authorships[13].institutions[0].ror	https://ror.org/00za53h95
authorships[13].institutions[0].type	education
authorships[13].institutions[0].lineage	https://openalex.org/I145311948
authorships[13].institutions[0].country_code	US
authorships[13].institutions[0].display_name	Johns Hopkins University
authorships[13].institutions[1].id	https://openalex.org/I6059380
authorships[13].institutions[1].ror	https://ror.org/024gw2733
authorships[13].institutions[1].type	education
authorships[13].institutions[1].lineage	https://openalex.org/I6059380
authorships[13].institutions[1].country_code	US
authorships[13].institutions[1].display_name	University of Baltimore
authorships[13].author_position	middle
authorships[13].raw_author_name	Wentao Zhan
authorships[13].is_corresponding	False
authorships[13].raw_affiliation_strings	Baltimore, MD, USA, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
authorships[14].author.id	https://openalex.org/A5111414246
authorships[14].author.orcid
authorships[14].author.display_name	Dipika Singh
authorships[14].countries	US
authorships[14].affiliations[0].institution_ids	https://openalex.org/I1299907687
authorships[14].affiliations[0].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[14].affiliations[1].institution_ids	https://openalex.org/I4210164401
authorships[14].affiliations[1].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[14].institutions[0].id	https://openalex.org/I1299907687
authorships[14].institutions[0].ror	https://ror.org/02rdpzb15
authorships[14].institutions[0].type	company
authorships[14].institutions[0].lineage	https://openalex.org/I1299907687
authorships[14].institutions[0].country_code	US
authorships[14].institutions[0].display_name	Bloomberg (United States)
authorships[14].institutions[1].id	https://openalex.org/I4210164401
authorships[14].institutions[1].ror	https://ror.org/05m5b8x20
authorships[14].institutions[1].type	facility
authorships[14].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[14].institutions[1].country_code	US
authorships[14].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[14].author_position	middle
authorships[14].raw_author_name	Dipika Singh
authorships[14].is_corresponding	False
authorships[14].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[15].author.id	https://openalex.org/A5114037078
authorships[15].author.orcid
authorships[15].author.display_name	Rufiaat Rashid
authorships[15].countries	US
authorships[15].affiliations[0].institution_ids	https://openalex.org/I4210164401
authorships[15].affiliations[0].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[15].affiliations[1].institution_ids	https://openalex.org/I1299907687
authorships[15].affiliations[1].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[15].institutions[0].id	https://openalex.org/I1299907687
authorships[15].institutions[0].ror	https://ror.org/02rdpzb15
authorships[15].institutions[0].type	company
authorships[15].institutions[0].lineage	https://openalex.org/I1299907687
authorships[15].institutions[0].country_code	US
authorships[15].institutions[0].display_name	Bloomberg (United States)
authorships[15].institutions[1].id	https://openalex.org/I4210164401
authorships[15].institutions[1].ror	https://ror.org/05m5b8x20
authorships[15].institutions[1].type	facility
authorships[15].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[15].institutions[1].country_code	US
authorships[15].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[15].author_position	middle
authorships[15].raw_author_name	Rufiaat Rashid
authorships[15].is_corresponding	False
authorships[15].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[16].author.id	https://openalex.org/A5027779740
authorships[16].author.orcid	https://orcid.org/0000-0003-3192-0865
authorships[16].author.display_name	Marisa Mitchell-Flack
authorships[16].countries	US
authorships[16].affiliations[0].institution_ids	https://openalex.org/I1299907687
authorships[16].affiliations[0].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[16].affiliations[1].institution_ids	https://openalex.org/I4210164401
authorships[16].affiliations[1].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[16].institutions[0].id	https://openalex.org/I1299907687
authorships[16].institutions[0].ror	https://ror.org/02rdpzb15
authorships[16].institutions[0].type	company
authorships[16].institutions[0].lineage	https://openalex.org/I1299907687
authorships[16].institutions[0].country_code	US
authorships[16].institutions[0].display_name	Bloomberg (United States)
authorships[16].institutions[1].id	https://openalex.org/I4210164401
authorships[16].institutions[1].ror	https://ror.org/05m5b8x20
authorships[16].institutions[1].type	facility
authorships[16].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[16].institutions[1].country_code	US
authorships[16].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[16].author_position	middle
authorships[16].raw_author_name	Marisa Mitchell-Flack
authorships[16].is_corresponding	False
authorships[16].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[17].author.id	https://openalex.org/A5042940622
authorships[17].author.orcid	https://orcid.org/0009-0007-2194-1511
authorships[17].author.display_name	Sadhana Bom
authorships[17].countries	US
authorships[17].affiliations[0].institution_ids	https://openalex.org/I4210164401
authorships[17].affiliations[0].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[17].affiliations[1].institution_ids	https://openalex.org/I1299907687
authorships[17].affiliations[1].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[17].institutions[0].id	https://openalex.org/I1299907687
authorships[17].institutions[0].ror	https://ror.org/02rdpzb15
authorships[17].institutions[0].type	company
authorships[17].institutions[0].lineage	https://openalex.org/I1299907687
authorships[17].institutions[0].country_code	US
authorships[17].institutions[0].display_name	Bloomberg (United States)
authorships[17].institutions[1].id	https://openalex.org/I4210164401
authorships[17].institutions[1].ror	https://ror.org/05m5b8x20
authorships[17].institutions[1].type	facility
authorships[17].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[17].institutions[1].country_code	US
authorships[17].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[17].author_position	middle
authorships[17].raw_author_name	Sadhana Bom
authorships[17].is_corresponding	False
authorships[17].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[18].author.id	https://openalex.org/A5067412752
authorships[18].author.orcid	https://orcid.org/0000-0001-6828-5290
authorships[18].author.display_name	Ada Tam
authorships[18].countries	US
authorships[18].affiliations[0].institution_ids	https://openalex.org/I1299907687
authorships[18].affiliations[0].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[18].affiliations[1].institution_ids	https://openalex.org/I4210164401
authorships[18].affiliations[1].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[18].institutions[0].id	https://openalex.org/I1299907687
authorships[18].institutions[0].ror	https://ror.org/02rdpzb15
authorships[18].institutions[0].type	company
authorships[18].institutions[0].lineage	https://openalex.org/I1299907687
authorships[18].institutions[0].country_code	US
authorships[18].institutions[0].display_name	Bloomberg (United States)
authorships[18].institutions[1].id	https://openalex.org/I4210164401
authorships[18].institutions[1].ror	https://ror.org/05m5b8x20
authorships[18].institutions[1].type	facility
authorships[18].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[18].institutions[1].country_code	US
authorships[18].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[18].author_position	middle
authorships[18].raw_author_name	Ada Tam
authorships[18].is_corresponding	False
authorships[18].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[19].author.id	https://openalex.org/A5022288785
authorships[19].author.orcid
authorships[19].author.display_name	Nick Ionta
authorships[19].countries	US
authorships[19].affiliations[0].institution_ids	https://openalex.org/I4210164401
authorships[19].affiliations[0].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[19].affiliations[1].institution_ids	https://openalex.org/I1299907687
authorships[19].affiliations[1].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[19].institutions[0].id	https://openalex.org/I1299907687
authorships[19].institutions[0].ror	https://ror.org/02rdpzb15
authorships[19].institutions[0].type	company
authorships[19].institutions[0].lineage	https://openalex.org/I1299907687
authorships[19].institutions[0].country_code	US
authorships[19].institutions[0].display_name	Bloomberg (United States)
authorships[19].institutions[1].id	https://openalex.org/I4210164401
authorships[19].institutions[1].ror	https://ror.org/05m5b8x20
authorships[19].institutions[1].type	facility
authorships[19].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[19].institutions[1].country_code	US
authorships[19].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[19].author_position	middle
authorships[19].raw_author_name	Nick Ionta
authorships[19].is_corresponding	False
authorships[19].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[20].author.id	https://openalex.org/A5101658846
authorships[20].author.orcid	https://orcid.org/0000-0001-6639-0054
authorships[20].author.display_name	Yi Wang
authorships[20].countries	US
authorships[20].affiliations[0].institution_ids	https://openalex.org/I6059380
authorships[20].affiliations[0].raw_affiliation_string	Baltimore, MD, USA
authorships[20].affiliations[1].institution_ids	https://openalex.org/I145311948
authorships[20].affiliations[1].raw_affiliation_string	Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
authorships[20].institutions[0].id	https://openalex.org/I145311948
authorships[20].institutions[0].ror	https://ror.org/00za53h95
authorships[20].institutions[0].type	education
authorships[20].institutions[0].lineage	https://openalex.org/I145311948
authorships[20].institutions[0].country_code	US
authorships[20].institutions[0].display_name	Johns Hopkins University
authorships[20].institutions[1].id	https://openalex.org/I6059380
authorships[20].institutions[1].ror	https://ror.org/024gw2733
authorships[20].institutions[1].type	education
authorships[20].institutions[1].lineage	https://openalex.org/I6059380
authorships[20].institutions[1].country_code	US
authorships[20].institutions[1].display_name	University of Baltimore
authorships[20].author_position	middle
authorships[20].raw_author_name	Yi Wang
authorships[20].is_corresponding	False
authorships[20].raw_affiliation_strings	Baltimore, MD, USA, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
authorships[21].author.id	https://openalex.org/A5060136207
authorships[21].author.orcid
authorships[21].author.display_name	Camille A. Sawosik
authorships[21].countries	US
authorships[21].affiliations[0].institution_ids	https://openalex.org/I4210164401
authorships[21].affiliations[0].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[21].affiliations[1].institution_ids	https://openalex.org/I1299907687
authorships[21].affiliations[1].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[21].institutions[0].id	https://openalex.org/I1299907687
authorships[21].institutions[0].ror	https://ror.org/02rdpzb15
authorships[21].institutions[0].type	company
authorships[21].institutions[0].lineage	https://openalex.org/I1299907687
authorships[21].institutions[0].country_code	US
authorships[21].institutions[0].display_name	Bloomberg (United States)
authorships[21].institutions[1].id	https://openalex.org/I4210164401
authorships[21].institutions[1].ror	https://ror.org/05m5b8x20
authorships[21].institutions[1].type	facility
authorships[21].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[21].institutions[1].country_code	US
authorships[21].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[21].author_position	middle
authorships[21].raw_author_name	Camille A. Sawosik
authorships[21].is_corresponding	False
authorships[21].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[22].author.id	https://openalex.org/A5006776456
authorships[22].author.orcid
authorships[22].author.display_name	Lauren E. Tirado
authorships[22].countries	US
authorships[22].affiliations[0].institution_ids	https://openalex.org/I4210164401
authorships[22].affiliations[0].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[22].affiliations[1].institution_ids	https://openalex.org/I1299907687
authorships[22].affiliations[1].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[22].institutions[0].id	https://openalex.org/I1299907687
authorships[22].institutions[0].ror	https://ror.org/02rdpzb15
authorships[22].institutions[0].type	company
authorships[22].institutions[0].lineage	https://openalex.org/I1299907687
authorships[22].institutions[0].country_code	US
authorships[22].institutions[0].display_name	Bloomberg (United States)
authorships[22].institutions[1].id	https://openalex.org/I4210164401
authorships[22].institutions[1].ror	https://ror.org/05m5b8x20
authorships[22].institutions[1].type	facility
authorships[22].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[22].institutions[1].country_code	US
authorships[22].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[22].author_position	middle
authorships[22].raw_author_name	Lauren E. Tirado
authorships[22].is_corresponding	False
authorships[22].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[23].author.id	https://openalex.org/A5007150765
authorships[23].author.orcid	https://orcid.org/0000-0002-1459-3252
authorships[23].author.display_name	Luke M. Tomasovic
authorships[23].countries	US
authorships[23].affiliations[0].institution_ids	https://openalex.org/I4210164401
authorships[23].affiliations[0].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[23].affiliations[1].institution_ids	https://openalex.org/I1299907687
authorships[23].affiliations[1].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[23].institutions[0].id	https://openalex.org/I1299907687
authorships[23].institutions[0].ror	https://ror.org/02rdpzb15
authorships[23].institutions[0].type	company
authorships[23].institutions[0].lineage	https://openalex.org/I1299907687
authorships[23].institutions[0].country_code	US
authorships[23].institutions[0].display_name	Bloomberg (United States)
authorships[23].institutions[1].id	https://openalex.org/I4210164401
authorships[23].institutions[1].ror	https://ror.org/05m5b8x20
authorships[23].institutions[1].type	facility
authorships[23].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[23].institutions[1].country_code	US
authorships[23].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[23].author_position	middle
authorships[23].raw_author_name	Luke M. Tomasovic
authorships[23].is_corresponding	False
authorships[23].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[24].author.id	https://openalex.org/A5012331628
authorships[24].author.orcid	https://orcid.org/0000-0002-0494-7184
authorships[24].author.display_name	Derek VanDyke
authorships[24].countries	US
authorships[24].affiliations[0].institution_ids	https://openalex.org/I6059380
authorships[24].affiliations[0].raw_affiliation_string	Department of Chemical and Biomolecular Engineering, Baltimore, MD, USA
authorships[24].affiliations[1].raw_affiliation_string	Translational Tissue Engineering Center, Baltimore, MD, USA
authorships[24].institutions[0].id	https://openalex.org/I6059380
authorships[24].institutions[0].ror	https://ror.org/024gw2733
authorships[24].institutions[0].type	education
authorships[24].institutions[0].lineage	https://openalex.org/I6059380
authorships[24].institutions[0].country_code	US
authorships[24].institutions[0].display_name	University of Baltimore
authorships[24].author_position	middle
authorships[24].raw_author_name	Derek VanDyke
authorships[24].is_corresponding	False
authorships[24].raw_affiliation_strings	Department of Chemical and Biomolecular Engineering, Baltimore, MD, USA, Translational Tissue Engineering Center, Baltimore, MD, USA
authorships[25].author.id	https://openalex.org/A5083417237
authorships[25].author.orcid	https://orcid.org/0000-0001-8187-3732
authorships[25].author.display_name	Jamie B. Spangler
authorships[25].countries	US
authorships[25].affiliations[0].raw_affiliation_string	Translational Tissue Engineering Center, Baltimore, MD, USA
authorships[25].affiliations[1].institution_ids	https://openalex.org/I6059380
authorships[25].affiliations[1].raw_affiliation_string	Department of Chemical and Biomolecular Engineering, Baltimore, MD, USA
authorships[25].affiliations[2].institution_ids	https://openalex.org/I4210164401
authorships[25].affiliations[2].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[25].affiliations[3].institution_ids	https://openalex.org/I1299907687
authorships[25].affiliations[3].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[25].affiliations[4].institution_ids	https://openalex.org/I6059380
authorships[25].affiliations[4].raw_affiliation_string	Department of Biomedical Engineering, Baltimore, MD, USA
authorships[25].institutions[0].id	https://openalex.org/I1299907687
authorships[25].institutions[0].ror	https://ror.org/02rdpzb15
authorships[25].institutions[0].type	company
authorships[25].institutions[0].lineage	https://openalex.org/I1299907687
authorships[25].institutions[0].country_code	US
authorships[25].institutions[0].display_name	Bloomberg (United States)
authorships[25].institutions[1].id	https://openalex.org/I4210164401
authorships[25].institutions[1].ror	https://ror.org/05m5b8x20
authorships[25].institutions[1].type	facility
authorships[25].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[25].institutions[1].country_code	US
authorships[25].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[25].institutions[2].id	https://openalex.org/I6059380
authorships[25].institutions[2].ror	https://ror.org/024gw2733
authorships[25].institutions[2].type	education
authorships[25].institutions[2].lineage	https://openalex.org/I6059380
authorships[25].institutions[2].country_code	US
authorships[25].institutions[2].display_name	University of Baltimore
authorships[25].author_position	middle
authorships[25].raw_author_name	Jamie B. Spangler
authorships[25].is_corresponding	False
authorships[25].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Department of Biomedical Engineering, Baltimore, MD, USA, Department of Chemical and Biomolecular Engineering, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA, Translational Tissue Engineering Center, Baltimore, MD, USA
authorships[26].author.id	https://openalex.org/A5056510071
authorships[26].author.orcid	https://orcid.org/0000-0001-9480-3047
authorships[26].author.display_name	Valsamo Anagnostou
authorships[26].countries	US
authorships[26].affiliations[0].institution_ids	https://openalex.org/I1299907687
authorships[26].affiliations[0].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[26].affiliations[1].institution_ids	https://openalex.org/I4210164401
authorships[26].affiliations[1].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[26].institutions[0].id	https://openalex.org/I1299907687
authorships[26].institutions[0].ror	https://ror.org/02rdpzb15
authorships[26].institutions[0].type	company
authorships[26].institutions[0].lineage	https://openalex.org/I1299907687
authorships[26].institutions[0].country_code	US
authorships[26].institutions[0].display_name	Bloomberg (United States)
authorships[26].institutions[1].id	https://openalex.org/I4210164401
authorships[26].institutions[1].ror	https://ror.org/05m5b8x20
authorships[26].institutions[1].type	facility
authorships[26].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[26].institutions[1].country_code	US
authorships[26].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[26].author_position	middle
authorships[26].raw_author_name	Valsamo Anagnostou
authorships[26].is_corresponding	False
authorships[26].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[27].author.id	https://openalex.org/A5019578689
authorships[27].author.orcid	https://orcid.org/0000-0003-2188-3407
authorships[27].author.display_name	Stephen C. Yang
authorships[27].countries	US
authorships[27].affiliations[0].institution_ids	https://openalex.org/I4210164401
authorships[27].affiliations[0].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[27].institutions[0].id	https://openalex.org/I4210164401
authorships[27].institutions[0].ror	https://ror.org/05m5b8x20
authorships[27].institutions[0].type	facility
authorships[27].institutions[0].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[27].institutions[0].country_code	US
authorships[27].institutions[0].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[27].author_position	middle
authorships[27].raw_author_name	Stephen Yang
authorships[27].is_corresponding	False
authorships[27].raw_affiliation_strings	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[28].author.id	https://openalex.org/A5049486044
authorships[28].author.orcid	https://orcid.org/0000-0003-2708-1309
authorships[28].author.display_name	Jonathan Spicer
authorships[28].countries	CA
authorships[28].affiliations[0].institution_ids	https://openalex.org/I5023651
authorships[28].affiliations[0].raw_affiliation_string	Department of Surgery, McGill University, Montreal, Canada
authorships[28].institutions[0].id	https://openalex.org/I5023651
authorships[28].institutions[0].ror	https://ror.org/01pxwe438
authorships[28].institutions[0].type	education
authorships[28].institutions[0].lineage	https://openalex.org/I5023651
authorships[28].institutions[0].country_code	CA
authorships[28].institutions[0].display_name	McGill University
authorships[28].author_position	middle
authorships[28].raw_author_name	Jonathan Spicer
authorships[28].is_corresponding	False
authorships[28].raw_affiliation_strings	Department of Surgery, McGill University, Montreal, Canada
authorships[29].author.id	https://openalex.org/A5086581000
authorships[29].author.orcid	https://orcid.org/0000-0001-7508-020X
authorships[29].author.display_name	Roni Rayes
authorships[29].countries	CA
authorships[29].affiliations[0].institution_ids	https://openalex.org/I5023651
authorships[29].affiliations[0].raw_affiliation_string	Department of Surgery, McGill University, Montreal, Canada
authorships[29].institutions[0].id	https://openalex.org/I5023651
authorships[29].institutions[0].ror	https://ror.org/01pxwe438
authorships[29].institutions[0].type	education
authorships[29].institutions[0].lineage	https://openalex.org/I5023651
authorships[29].institutions[0].country_code	CA
authorships[29].institutions[0].display_name	McGill University
authorships[29].author_position	middle
authorships[29].raw_author_name	Roni Rayes
authorships[29].is_corresponding	False
authorships[29].raw_affiliation_strings	Department of Surgery, McGill University, Montreal, Canada
authorships[30].author.id	https://openalex.org/A5035471137
authorships[30].author.orcid	https://orcid.org/0000-0002-8273-4395
authorships[30].author.display_name	Janis M. Taube
authorships[30].countries	US
authorships[30].affiliations[0].institution_ids	https://openalex.org/I1299907687
authorships[30].affiliations[0].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[30].affiliations[1].institution_ids	https://openalex.org/I4210164401
authorships[30].affiliations[1].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[30].affiliations[2].institution_ids	https://openalex.org/I2802640032
authorships[30].affiliations[2].raw_affiliation_string	The Mark Foundation Center for Advanced Genomics and Imaging, Baltimore, MD, USA
authorships[30].institutions[0].id	https://openalex.org/I1299907687
authorships[30].institutions[0].ror	https://ror.org/02rdpzb15
authorships[30].institutions[0].type	company
authorships[30].institutions[0].lineage	https://openalex.org/I1299907687
authorships[30].institutions[0].country_code	US
authorships[30].institutions[0].display_name	Bloomberg (United States)
authorships[30].institutions[1].id	https://openalex.org/I2802640032
authorships[30].institutions[1].ror	https://ror.org/0377f6951
authorships[30].institutions[1].type	nonprofit
authorships[30].institutions[1].lineage	https://openalex.org/I2802640032
authorships[30].institutions[1].country_code	US
authorships[30].institutions[1].display_name	Foundation Center
authorships[30].institutions[2].id	https://openalex.org/I4210164401
authorships[30].institutions[2].ror	https://ror.org/05m5b8x20
authorships[30].institutions[2].type	facility
authorships[30].institutions[2].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[30].institutions[2].country_code	US
authorships[30].institutions[2].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[30].author_position	middle
authorships[30].raw_author_name	Janis Taube
authorships[30].is_corresponding	False
authorships[30].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA, The Mark Foundation Center for Advanced Genomics and Imaging, Baltimore, MD, USA
authorships[31].author.id	https://openalex.org/A5018401879
authorships[31].author.orcid	https://orcid.org/0000-0002-2443-8395
authorships[31].author.display_name	Julie R. Brahmer
authorships[31].countries	US
authorships[31].affiliations[0].institution_ids	https://openalex.org/I1299907687
authorships[31].affiliations[0].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[31].affiliations[1].institution_ids	https://openalex.org/I4210164401
authorships[31].affiliations[1].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[31].institutions[0].id	https://openalex.org/I1299907687
authorships[31].institutions[0].ror	https://ror.org/02rdpzb15
authorships[31].institutions[0].type	company
authorships[31].institutions[0].lineage	https://openalex.org/I1299907687
authorships[31].institutions[0].country_code	US
authorships[31].institutions[0].display_name	Bloomberg (United States)
authorships[31].institutions[1].id	https://openalex.org/I4210164401
authorships[31].institutions[1].ror	https://ror.org/05m5b8x20
authorships[31].institutions[1].type	facility
authorships[31].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[31].institutions[1].country_code	US
authorships[31].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[31].author_position	middle
authorships[31].raw_author_name	Julie R. Brahmer
authorships[31].is_corresponding	False
authorships[31].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[32].author.id	https://openalex.org/A5059543131
authorships[32].author.orcid	https://orcid.org/0000-0001-6925-6344
authorships[32].author.display_name	Patrick M. Forde
authorships[32].countries	US
authorships[32].affiliations[0].institution_ids	https://openalex.org/I4210164401
authorships[32].affiliations[0].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[32].affiliations[1].institution_ids	https://openalex.org/I1299907687
authorships[32].affiliations[1].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[32].institutions[0].id	https://openalex.org/I1299907687
authorships[32].institutions[0].ror	https://ror.org/02rdpzb15
authorships[32].institutions[0].type	company
authorships[32].institutions[0].lineage	https://openalex.org/I1299907687
authorships[32].institutions[0].country_code	US
authorships[32].institutions[0].display_name	Bloomberg (United States)
authorships[32].institutions[1].id	https://openalex.org/I4210164401
authorships[32].institutions[1].ror	https://ror.org/05m5b8x20
authorships[32].institutions[1].type	facility
authorships[32].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[32].institutions[1].country_code	US
authorships[32].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[32].author_position	middle
authorships[32].raw_author_name	Patrick M. Forde
authorships[32].is_corresponding	False
authorships[32].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[33].author.id	https://openalex.org/A5086896931
authorships[33].author.orcid	https://orcid.org/0000-0003-0744-6606
authorships[33].author.display_name	Srinivasan Yegnasubramanian
authorships[33].countries	US
authorships[33].affiliations[0].institution_ids	https://openalex.org/I4210164401
authorships[33].affiliations[0].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[33].affiliations[1].institution_ids	https://openalex.org/I1299907687
authorships[33].affiliations[1].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[33].institutions[0].id	https://openalex.org/I1299907687
authorships[33].institutions[0].ror	https://ror.org/02rdpzb15
authorships[33].institutions[0].type	company
authorships[33].institutions[0].lineage	https://openalex.org/I1299907687
authorships[33].institutions[0].country_code	US
authorships[33].institutions[0].display_name	Bloomberg (United States)
authorships[33].institutions[1].id	https://openalex.org/I4210164401
authorships[33].institutions[1].ror	https://ror.org/05m5b8x20
authorships[33].institutions[1].type	facility
authorships[33].institutions[1].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[33].institutions[1].country_code	US
authorships[33].institutions[1].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[33].author_position	middle
authorships[33].raw_author_name	Srinivasan Yegnasubramanian
authorships[33].is_corresponding	False
authorships[33].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[34].author.id	https://openalex.org/A5020874196
authorships[34].author.orcid	https://orcid.org/0000-0002-6480-0141
authorships[34].author.display_name	Hongkai Ji
authorships[34].countries	US
authorships[34].affiliations[0].institution_ids	https://openalex.org/I6059380
authorships[34].affiliations[0].raw_affiliation_string	Baltimore, MD, USA
authorships[34].affiliations[1].institution_ids	https://openalex.org/I145311948
authorships[34].affiliations[1].raw_affiliation_string	Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
authorships[34].institutions[0].id	https://openalex.org/I145311948
authorships[34].institutions[0].ror	https://ror.org/00za53h95
authorships[34].institutions[0].type	education
authorships[34].institutions[0].lineage	https://openalex.org/I145311948
authorships[34].institutions[0].country_code	US
authorships[34].institutions[0].display_name	Johns Hopkins University
authorships[34].institutions[1].id	https://openalex.org/I6059380
authorships[34].institutions[1].ror	https://ror.org/024gw2733
authorships[34].institutions[1].type	education
authorships[34].institutions[1].lineage	https://openalex.org/I6059380
authorships[34].institutions[1].country_code	US
authorships[34].institutions[1].display_name	University of Baltimore
authorships[34].author_position	middle
authorships[34].raw_author_name	Hongkai Ji
authorships[34].is_corresponding	False
authorships[34].raw_affiliation_strings	Baltimore, MD, USA, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
authorships[35].author.id	https://openalex.org/A5066707073
authorships[35].author.orcid	https://orcid.org/0000-0001-6215-1013
authorships[35].author.display_name	Drew M. Pardoll
authorships[35].countries	US
authorships[35].affiliations[0].institution_ids	https://openalex.org/I1299907687
authorships[35].affiliations[0].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[35].affiliations[1].institution_ids	https://openalex.org/I2802640032
authorships[35].affiliations[1].raw_affiliation_string	The Mark Foundation Center for Advanced Genomics and Imaging, Baltimore, MD, USA
authorships[35].affiliations[2].institution_ids	https://openalex.org/I4210164401
authorships[35].affiliations[2].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[35].institutions[0].id	https://openalex.org/I1299907687
authorships[35].institutions[0].ror	https://ror.org/02rdpzb15
authorships[35].institutions[0].type	company
authorships[35].institutions[0].lineage	https://openalex.org/I1299907687
authorships[35].institutions[0].country_code	US
authorships[35].institutions[0].display_name	Bloomberg (United States)
authorships[35].institutions[1].id	https://openalex.org/I2802640032
authorships[35].institutions[1].ror	https://ror.org/0377f6951
authorships[35].institutions[1].type	nonprofit
authorships[35].institutions[1].lineage	https://openalex.org/I2802640032
authorships[35].institutions[1].country_code	US
authorships[35].institutions[1].display_name	Foundation Center
authorships[35].institutions[2].id	https://openalex.org/I4210164401
authorships[35].institutions[2].ror	https://ror.org/05m5b8x20
authorships[35].institutions[2].type	facility
authorships[35].institutions[2].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[35].institutions[2].country_code	US
authorships[35].institutions[2].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[35].author_position	middle
authorships[35].raw_author_name	Drew M. Pardoll
authorships[35].is_corresponding	False
authorships[35].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA, The Mark Foundation Center for Advanced Genomics and Imaging, Baltimore, MD, USA
authorships[36].author.id	https://openalex.org/A5082613510
authorships[36].author.orcid	https://orcid.org/0000-0002-6295-8930
authorships[36].author.display_name	Kellie N. Smith
authorships[36].countries	US
authorships[36].affiliations[0].institution_ids	https://openalex.org/I4210164401
authorships[36].affiliations[0].raw_affiliation_string	Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
authorships[36].affiliations[1].institution_ids	https://openalex.org/I2802640032
authorships[36].affiliations[1].raw_affiliation_string	The Mark Foundation Center for Advanced Genomics and Imaging, Baltimore, MD, USA
authorships[36].affiliations[2].institution_ids	https://openalex.org/I1299907687
authorships[36].affiliations[2].raw_affiliation_string	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
authorships[36].institutions[0].id	https://openalex.org/I1299907687
authorships[36].institutions[0].ror	https://ror.org/02rdpzb15
authorships[36].institutions[0].type	company
authorships[36].institutions[0].lineage	https://openalex.org/I1299907687
authorships[36].institutions[0].country_code	US
authorships[36].institutions[0].display_name	Bloomberg (United States)
authorships[36].institutions[1].id	https://openalex.org/I2802640032
authorships[36].institutions[1].ror	https://ror.org/0377f6951
authorships[36].institutions[1].type	nonprofit
authorships[36].institutions[1].lineage	https://openalex.org/I2802640032
authorships[36].institutions[1].country_code	US
authorships[36].institutions[1].display_name	Foundation Center
authorships[36].institutions[2].id	https://openalex.org/I4210164401
authorships[36].institutions[2].ror	https://ror.org/05m5b8x20
authorships[36].institutions[2].type	facility
authorships[36].institutions[2].lineage	https://openalex.org/I2799853436, https://openalex.org/I4210164401
authorships[36].institutions[2].country_code	US
authorships[36].institutions[2].display_name	Sidney Kimmel Comprehensive Cancer Center
authorships[36].author_position	last
authorships[36].raw_author_name	Kellie N. Smith
authorships[36].is_corresponding	True
authorships[36].raw_affiliation_strings	Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA, The Mark Foundation Center for Advanced Genomics and Imaging, Baltimore, MD, USA
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://www.biorxiv.org/content/biorxiv/early/2022/12/15/2022.12.13.520329.full.pdf
open_access.oa_status	green
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Lung tumor-infiltrating T_reghave divergent transcriptional profiles and function linked to checkpoint blockade response
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10158
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9997000098228455
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2730
primary_topic.subfield.display_name	Oncology
primary_topic.display_name	Cancer Immunotherapy and Biomarkers
related_works	https://openalex.org/W4393219064, https://openalex.org/W2263980547, https://openalex.org/W2085972006, https://openalex.org/W4361271945, https://openalex.org/W3197188017, https://openalex.org/W4200507838, https://openalex.org/W4362515066, https://openalex.org/W4362158722, https://openalex.org/W3166800855, https://openalex.org/W2575161424
cited_by_count	0
locations_count	1
best_oa_location.id	doi:10.1101/2022.12.13.520329
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4306402567
best_oa_location.source.issn
best_oa_location.source.type	repository
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
best_oa_location.source.host_organization	https://openalex.org/I2750212522
best_oa_location.source.host_organization_name	Cold Spring Harbor Laboratory
best_oa_location.source.host_organization_lineage	https://openalex.org/I2750212522
best_oa_location.license	cc-by-nc
best_oa_location.pdf_url	https://www.biorxiv.org/content/biorxiv/early/2022/12/15/2022.12.13.520329.full.pdf
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by-nc
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1101/2022.12.13.520329
primary_location.id	doi:10.1101/2022.12.13.520329
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4306402567
primary_location.source.issn
primary_location.source.type	repository
primary_location.source.is_oa	False
primary_location.source.issn_l
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
primary_location.source.host_organization	https://openalex.org/I2750212522
primary_location.source.host_organization_name	Cold Spring Harbor Laboratory
primary_location.source.host_organization_lineage	https://openalex.org/I2750212522
primary_location.license	cc-by-nc
primary_location.pdf_url	https://www.biorxiv.org/content/biorxiv/early/2022/12/15/2022.12.13.520329.full.pdf
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by-nc
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1101/2022.12.13.520329
publication_date	2022-12-15
publication_year	2022
referenced_works	https://openalex.org/W2891326702, https://openalex.org/W3183254943, https://openalex.org/W3093511156, https://openalex.org/W2036117709, https://openalex.org/W2074419431, https://openalex.org/W2138163780, https://openalex.org/W2550291749, https://openalex.org/W2046609236, https://openalex.org/W1966972158, https://openalex.org/W3175617087, https://openalex.org/W2793411374, https://openalex.org/W2999410311, https://openalex.org/W3032968363, https://openalex.org/W3176344645, https://openalex.org/W2775205191, https://openalex.org/W3144622283, https://openalex.org/W2798160602, https://openalex.org/W4223502512, https://openalex.org/W3005081774, https://openalex.org/W3151163815, https://openalex.org/W4205449884, https://openalex.org/W2100474263, https://openalex.org/W3003487780, https://openalex.org/W2752027941, https://openalex.org/W3003852575, https://openalex.org/W2132427916, https://openalex.org/W2169233545, https://openalex.org/W2069545220, https://openalex.org/W2734998032, https://openalex.org/W2010008322, https://openalex.org/W2046749316, https://openalex.org/W1605315445, https://openalex.org/W2126991196, https://openalex.org/W2001621054, https://openalex.org/W2992446582, https://openalex.org/W1845038035, https://openalex.org/W2917226079, https://openalex.org/W2150901150, https://openalex.org/W2433064503, https://openalex.org/W2081360252, https://openalex.org/W2971333795, https://openalex.org/W2088570448, https://openalex.org/W2971302797, https://openalex.org/W1991344211, https://openalex.org/W3081294344, https://openalex.org/W4206589038, https://openalex.org/W767144479, https://openalex.org/W1964819336, https://openalex.org/W2220931159, https://openalex.org/W2910546986, https://openalex.org/W2088622301, https://openalex.org/W2126724696, https://openalex.org/W2169311271, https://openalex.org/W2724136428, https://openalex.org/W2073727431, https://openalex.org/W4313381628, https://openalex.org/W1928425848, https://openalex.org/W1499898280, https://openalex.org/W2157669002, https://openalex.org/W2809615201, https://openalex.org/W4229030906, https://openalex.org/W2867613812, https://openalex.org/W2949177718, https://openalex.org/W2980870655, https://openalex.org/W2759615793, https://openalex.org/W2984472267, https://openalex.org/W2025341678, https://openalex.org/W4298870207, https://openalex.org/W1545137049, https://openalex.org/W1946393286, https://openalex.org/W1996642272, https://openalex.org/W2786672974, https://openalex.org/W3164692211, https://openalex.org/W2102650038, https://openalex.org/W3145651106, https://openalex.org/W4226382697, https://openalex.org/W4399636900
referenced_works_count	77
abstract_inverted_index.(	199
abstract_inverted_index.)	6, 44
abstract_inverted_index.,	79
abstract_inverted_index.T	2, 40, 63, 120, 141, 169, 216, 278
abstract_inverted_index.a	67, 179, 184, 208, 225
abstract_inverted_index.(T	4
abstract_inverted_index.10	73, 272
abstract_inverted_index.In	30
abstract_inverted_index.We	71, 270
abstract_inverted_index.as	113, 115
abstract_inverted_index.by	104
abstract_inverted_index.ex	138
abstract_inverted_index.hi	129, 131
abstract_inverted_index.in	20, 119, 123, 133, 156, 232, 288, 299
abstract_inverted_index.is	28, 283, 294, 297
abstract_inverted_index.of	37, 59, 75, 81, 98, 144, 197, 207, 274, 281
abstract_inverted_index.on	252
abstract_inverted_index.to	10, 23, 152, 219, 265
abstract_inverted_index.we	33, 161
abstract_inverted_index.TAA	176
abstract_inverted_index.all	165
abstract_inverted_index.and	13, 47, 100, 110, 140, 147, 194, 202, 256, 286, 291, 296
abstract_inverted_index.are	7, 173
abstract_inverted_index.for	175
abstract_inverted_index.may	262
abstract_inverted_index.one	92, 280
abstract_inverted_index.reg	5, 41, 43, 64, 78, 89, 121, 142, 167, 217, 241, 261
abstract_inverted_index.the	127, 134, 157, 190, 212, 220, 292
abstract_inverted_index.was	230
abstract_inverted_index.GITR	130, 146
abstract_inverted_index.OX40	99, 128
abstract_inverted_index.PD-1	153, 300
abstract_inverted_index.cell	51, 57, 170
abstract_inverted_index.from	45, 66, 211
abstract_inverted_index.gene	209
abstract_inverted_index.have	83
abstract_inverted_index.high	84, 96
abstract_inverted_index.into	189, 243
abstract_inverted_index.lung	52, 275
abstract_inverted_index.most	80, 135
abstract_inverted_index.over	183
abstract_inverted_index.role	19
abstract_inverted_index.that	163, 172, 229, 239, 258
abstract_inverted_index.this	31
abstract_inverted_index.vivo	139
abstract_inverted_index.well	114
abstract_inverted_index.with	55, 86, 150, 248
abstract_inverted_index.(ICB)	27
abstract_inverted_index.FoxP3	193
abstract_inverted_index.GITR,	101
abstract_inverted_index.IFNγ	201
abstract_inverted_index.LAG3,	148
abstract_inverted_index.LAG3.	125
abstract_inverted_index.NF-kB	111
abstract_inverted_index.OX40,	145
abstract_inverted_index.TBX21	198
abstract_inverted_index.TIL-T	77, 88, 166, 240, 260
abstract_inverted_index.These	236
abstract_inverted_index.after	187
abstract_inverted_index.cells	3
abstract_inverted_index.entry	188
abstract_inverted_index.found	162
abstract_inverted_index.fully	177
abstract_inverted_index.genes	117
abstract_inverted_index.human	76, 221
abstract_inverted_index.naive	49
abstract_inverted_index.other	293
abstract_inverted_index.score	210
abstract_inverted_index.their	18
abstract_inverted_index.tumor	69, 159
abstract_inverted_index.which	82, 282
abstract_inverted_index.whose	102
abstract_inverted_index.(TIL-T	42
abstract_inverted_index.Tbet),	200
abstract_inverted_index.cells,	279
abstract_inverted_index.define	271
abstract_inverted_index.highly	136, 226, 284
abstract_inverted_index.immune	24
abstract_inverted_index.levels	97
abstract_inverted_index.ligand	106
abstract_inverted_index.model,	160
abstract_inverted_index.model.	70
abstract_inverted_index.murine	68, 87, 158, 213
abstract_inverted_index.period	186
abstract_inverted_index.single	56
abstract_inverted_index.study,	32
abstract_inverted_index.subset	93, 132, 218
abstract_inverted_index.tumor,	191
abstract_inverted_index.viewed	9
abstract_inverted_index.(NSCLC)	54
abstract_inverted_index.Summary	269
abstract_inverted_index.antigen	61
abstract_inverted_index.cancers	53
abstract_inverted_index.certain	203
abstract_inverted_index.cognate	105
abstract_inverted_index.dataset	223
abstract_inverted_index.derived	65
abstract_inverted_index.develop	178
abstract_inverted_index.effects	251
abstract_inverted_index.subsets	74, 247, 273
abstract_inverted_index.suggest	257
abstract_inverted_index.tumors.	235
abstract_inverted_index.Abstract	0
abstract_inverted_index.Notably,	91
abstract_inverted_index.Th1-like	181, 215, 295
abstract_inverted_index.analysis	58
abstract_inverted_index.blockade	26
abstract_inverted_index.distinct	180, 245
abstract_inverted_index.enriched	231, 287, 298
abstract_inverted_index.findings	237
abstract_inverted_index.however,	17
abstract_inverted_index.immunity	255
abstract_inverted_index.involved	118
abstract_inverted_index.mediated	107
abstract_inverted_index.multiple	116, 244
abstract_inverted_index.opposing	250
abstract_inverted_index.programs	109
abstract_inverted_index.revealed	224
abstract_inverted_index.specific	174
abstract_inverted_index.subsets.	90
abstract_inverted_index.suppress	11
abstract_inverted_index.two-week	185
abstract_inverted_index.unclear.	29
abstract_inverted_index.analogous	227
abstract_inverted_index.anti-PD-1	233, 289
abstract_inverted_index.blockade.	154
abstract_inverted_index.expresses	95
abstract_inverted_index.immunity;	16
abstract_inverted_index.non-small	50
abstract_inverted_index.partition	242
abstract_inverted_index.receptors	171
abstract_inverted_index.responses	22
abstract_inverted_index.signature	182
abstract_inverted_index.treatment	48
abstract_inverted_index.virtually	164
abstract_inverted_index.>73,000	38
abstract_inverted_index.Regulatory	1
abstract_inverted_index.anti-tumor	15, 254, 266
abstract_inverted_index.checkpoint	25
abstract_inverted_index.contribute	264
abstract_inverted_index.correlated	149
abstract_inverted_index.endogenous	12
abstract_inverted_index.expressing	168
abstract_inverted_index.expression	143, 196
abstract_inverted_index.granzymes.	205
abstract_inverted_index.identified	72
abstract_inverted_index.integrated	34
abstract_inverted_index.modulating	21
abstract_inverted_index.particular	124
abstract_inverted_index.positively	263
abstract_inverted_index.regulatory	277
abstract_inverted_index.resistance	151
abstract_inverted_index.responding	234
abstract_inverted_index.responses.	267
abstract_inverted_index.subcluster	228
abstract_inverted_index.Application	206
abstract_inverted_index.ICB-induced	253
abstract_inverted_index.activation,	112
abstract_inverted_index.concordance	85
abstract_inverted_index.demonstrate	238
abstract_inverted_index.engangement	103
abstract_inverted_index.potentially	249
abstract_inverted_index.responders.	301
abstract_inverted_index.selectively	94
abstract_inverted_index.single-cell	35, 222
abstract_inverted_index.suppressive	137, 285
abstract_inverted_index.One-Sentence	268
abstract_inverted_index.TAA-specific	214, 259
abstract_inverted_index.suppression,	122
abstract_inverted_index.Functionally,	126
abstract_inverted_index.RNAseq/TCRseq	36
abstract_inverted_index.Surprisingly,	155
abstract_inverted_index.proliferative	108
abstract_inverted_index.up-regulating	195
abstract_inverted_index.(TAA)-specific	62
abstract_inverted_index.conventionally	8
abstract_inverted_index.non-responders	290
abstract_inverted_index.therapyinduced	14
abstract_inverted_index.down-regulating	192
abstract_inverted_index.pro-inflammatory	204
abstract_inverted_index.tumor-associated	60
abstract_inverted_index.anti-PD-1-treated	46
abstract_inverted_index.tumor-infiltrating	39
abstract_inverted_index.cancer-infiltrating	276
abstract_inverted_index.transcriptionally-defined	246
cited_by_percentile_year
corresponding_author_ids	https://openalex.org/A5082613510
countries_distinct_count	2
institutions_distinct_count	37
corresponding_institution_ids	https://openalex.org/I1299907687, https://openalex.org/I2802640032, https://openalex.org/I4210164401
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.8199999928474426
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.27001166
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False

Lung tumor-infiltrating Treghave divergent transcriptional profiles and function linked to checkpoint blockade response Article Swipe

Related Topics

Raw OpenAlex JSON

Full payload

Lung tumor-infiltrating T_reghave divergent transcriptional profiles and function linked to checkpoint blockade response Article Swipe