m6A Modification: A Double-Edged Sword in Tumor Development Article Swipe
Runnan Gao
,
Mujie Ye
,
Baihui Liu
,
Meng Wei
,
Duan Ma
,
Kuiran Dong
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2021.679367
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2021.679367
Modification of m6A, as the most abundant mRNA modification, plays diverse roles in various biological processes in eukaryotes. Emerging evidence has revealed that m6A modification is closely associated with the activation and inhibition of tumor pathways, and it is significantly linked to the prognosis of cancer patients. Aberrant reduction or elevated expression of m6A regulators and of m6A itself have been identified in numerous tumors. In this review, we give a description of the dynamic properties of m6A modification regulators, such as methyltransferases, demethylases, and m6A binding proteins, and indicate the value of the balance between these proteins in regulating the expression of diverse genes and the underlying effects on cancer development. Furthermore, we summarize the “dual-edged weapon” role of RNA methylation in tumor progression and discuss that RNA methylation can not only result in tumorigenesis but also lead to suppression of tumor formation. In addition, we summarize the latest research progress on small-molecule targeting of m6A regulators to inhibit or activate m6A. These studies indicate that restoring the balance of m6A modification via targeting specific imbalanced regulators may be a novel anti-cancer strategy.
Related Topics
Concepts
Methyltransferase
Biology
Carcinogenesis
RNA
Methylation
RNA methylation
Cancer research
Cell biology
Cancer
Gene
Genetics
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fonc.2021.679367
- https://www.frontiersin.org/articles/10.3389/fonc.2021.679367/pdf
- OA Status
- gold
- Cited By
- 87
- References
- 114
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3185008783
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3185008783Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fonc.2021.679367Digital Object Identifier
- Title
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m6A Modification: A Double-Edged Sword in Tumor DevelopmentWork title
- Type
-
reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-07-26Full publication date if available
- Authors
-
Runnan Gao, Mujie Ye, Baihui Liu, Meng Wei, Duan Ma, Kuiran DongList of authors in order
- Landing page
-
https://doi.org/10.3389/fonc.2021.679367Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fonc.2021.679367/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fonc.2021.679367/pdfDirect OA link when available
- Concepts
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Methyltransferase, Biology, Carcinogenesis, RNA, Methylation, RNA methylation, Cancer research, Cell biology, Cancer, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
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-
87Total citation count in OpenAlex
- Citations by year (recent)
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2025: 13, 2024: 27, 2023: 27, 2022: 18, 2021: 2Per-year citation counts (last 5 years)
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114Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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