Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT ‐mTOR ‐TFEB Signaling Pathway
Article Swipe
Yuxuan Zhu
,
Yang Shu
,
Shenkai Su
,
Yeheng Huang
,
Yu‐Li Chen
,
Haibo Liang
,
Jiansen Miao
,
Zhouwei Wu
,
Xiang Li
,
Jian Xiao
,
Xiangyang Wang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/ptr.8473
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/ptr.8473
Spinal cord injury (SCI) presents considerable therapeutic challenges due to its complex pathophysiology, and effective treatments are currently lacking. Macelignan (Mace) has shown therapeutic effects in some neurological disorders, but its potential to enhance functional recovery in SCI and the underlying mechanisms are not well understood. This research endeavors to explore the therapeutic value of Mace in SCI and its underlying mechanism of action. A mouse model of SCI was established, and the mice were randomly divided into 13 groups: Sham, Sham + Mace, SCI, SCI + 25 mg/kg Mace, SCI + Mace, SCI + 75 mg/kg Mace, SCI + 100 mg/kg Mace, SCI + 3MA, SCI + Mace/3MA, SCI + Mace/Scramble shRNA, SCI + Mace/TFEB shRNA, SCI + SC79, and SCI + Mace/SC79. Histological examinations were conducted using hematoxylin and eosin (HE), Masson's trichrome, and Nissl staining techniques. Functional recovery post‐injury was evaluated through footprint analysis and the Basso Mouse Scale (BMS). The levels of proteins associated with pyroptosis and autophagy were quantified using qPCR, protein immunoblotting, and immunofluorescence (IF). Network pharmacology techniques were applied to elucidate the signaling pathways modulated by Mace. Mace facilitated functional recovery following SCI by augmenting autophagy and diminishing pyroptosis, with these effects being partially counteracted by 3‐Methyladenine (3MA). It was noted that Mace induced autophagy via inhibition of the AKT‐mTOR signaling pathway, leading to an increase in TFEB expression. As an autophagy activator, Mace induces TFEB‐mediated autophagy and inhibits pyroptosis, which supports functional recovery post‐SCI, indicating its potential clinical relevance.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/ptr.8473
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ptr.8473
- OA Status
- bronze
- Cited By
- 3
- References
- 74
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408301116
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4408301116Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/ptr.8473Digital Object Identifier
- Title
-
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the
AKT ‐mTOR ‐TFEB Signaling PathwayWork title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-10Full publication date if available
- Authors
-
Yuxuan Zhu, Yang Shu, Shenkai Su, Yeheng Huang, Yu‐Li Chen, Haibo Liang, Jiansen Miao, Zhouwei Wu, Xiang Li, Jian Xiao, Xiangyang WangList of authors in order
- Landing page
-
https://doi.org/10.1002/ptr.8473Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ptr.8473Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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-
bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ptr.8473Direct OA link when available
- Concepts
-
Mace, PI3K/AKT/mTOR pathway, Autophagy, Spinal cord injury, Protein kinase B, Medicine, Pharmacology, Cell biology, Chemistry, Signal transduction, Neuroscience, Biology, Internal medicine, Spinal cord, Apoptosis, Biochemistry, Conventional PCI, Myocardial infarctionTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3Per-year citation counts (last 5 years)
- References (count)
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74Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2396039754, https://openalex.org/W2484283047, https://openalex.org/W6722240368, https://openalex.org/W3058784328, https://openalex.org/W2981934625, https://openalex.org/W6769133519, https://openalex.org/W2078618558, https://openalex.org/W2806423234, https://openalex.org/W3134372233, https://openalex.org/W3149666027, https://openalex.org/W2989083977, https://openalex.org/W6770410030, https://openalex.org/W4283156085, https://openalex.org/W4280595414, https://openalex.org/W3105421847, https://openalex.org/W2048822926, https://openalex.org/W2973219414, https://openalex.org/W237439666, https://openalex.org/W4285385945, https://openalex.org/W2896970933, https://openalex.org/W1982043636, https://openalex.org/W2022812113, https://openalex.org/W2627048017, https://openalex.org/W6739450425, https://openalex.org/W2773258360, https://openalex.org/W4311184268, https://openalex.org/W4385827604, https://openalex.org/W4285821898, https://openalex.org/W2935015991, https://openalex.org/W6761424798, https://openalex.org/W2748132373, https://openalex.org/W4200422903, https://openalex.org/W3009940926, https://openalex.org/W6774836746, https://openalex.org/W4387340888, https://openalex.org/W6856985645, https://openalex.org/W4290725612, https://openalex.org/W2565398910, https://openalex.org/W3028977251, https://openalex.org/W2293027573, https://openalex.org/W4311916957, https://openalex.org/W2043939763, https://openalex.org/W3171124897, https://openalex.org/W1972498735, https://openalex.org/W3116176019, https://openalex.org/W6787576370, https://openalex.org/W2290466312, https://openalex.org/W1974808515, https://openalex.org/W4401363901, https://openalex.org/W4387230320, https://openalex.org/W2091222636, https://openalex.org/W4285243914, https://openalex.org/W6839548431, https://openalex.org/W2953566792, https://openalex.org/W3124756354, https://openalex.org/W2963539474, https://openalex.org/W6766227084, https://openalex.org/W2805395993, https://openalex.org/W4386878480, https://openalex.org/W6963201826, https://openalex.org/W4319984713, https://openalex.org/W2943988281, https://openalex.org/W2998520357, https://openalex.org/W4401497157, https://openalex.org/W4291511795, https://openalex.org/W6841707899, https://openalex.org/W2800531295, https://openalex.org/W4290729451, https://openalex.org/W1995762247, https://openalex.org/W3142080073, https://openalex.org/W6791902191, https://openalex.org/W4313569219, https://openalex.org/W3006826877, https://openalex.org/W4387118720 |
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