Macrophage conditioned media promotes adipocyte cancer-association, which in turn stimulates breast cancer proliferation and migration Article Swipe
Karin A. Vallega
,
Dale B. Bosco
,
Yi Ren
,
Qing‐Xiang Amy Sang
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-130272/v1
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-130272/v1
Background Breast cancer is the most common cancer in women and the leading cause of female cancer deaths worldwide. Obesity causes chronic inflammation and is a risk factor for post-menopausal breast cancer and poor prognosis. Obesity is known to trigger increased infiltration of macrophages into adipose tissue, yet little research has focused on the effects of macrophages in the early stages of breast tumor development in obese patients. In this study, the effects of pro-inflammatory macrophages on breast cancer-adipocyte crosstalk were investigated. Methods An innovative human cell co-culture system was used to model the paracrine interactions among adipocytes, macrophages, and breast cancer cells, and how they can facilitate tumor progression. The effects on human breast cancer cells were examined using cell counts and migration assays. Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was used to measure the expression levels of several cytokines and proteases to analyze adipocyte cancer-association. Results Macrophage conditioned media intensified the effects of breast cancer-adipocyte crosstalk. More specifically, adipocytes became delipidated and increased production of pro-inflammatory cytokines, even in the absence of breast cancer cells, although the expression levels were highest with all three cell components. As a result, co-cultured breast cancer cells became more aggressive, with increased proliferation and migration potential when compared to adipocyte-breast cancer cell co-cultures treated with unconditioned media. Conclusions Macrophage conditioned media promotes adipocyte cancer-association and production of pro-inflammatory factors. These macrophage-adipocyte paracrine interactions promote human breast cancer cell proliferation and migration. Thus, macrophages may contribute to adipocyte inflammation and cancer-association and promote breast cancer progression.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-130272/v1
- https://www.researchsquare.com/article/rs-130272/v1.pdf?c=1631881991000
- OA Status
- green
- References
- 18
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3115225406
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3115225406Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-130272/v1Digital Object Identifier
- Title
-
Macrophage conditioned media promotes adipocyte cancer-association, which in turn stimulates breast cancer proliferation and migrationWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-12-18Full publication date if available
- Authors
-
Karin A. Vallega, Dale B. Bosco, Yi Ren, Qing‐Xiang Amy SangList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-130272/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-130272/v1.pdf?c=1631881991000Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-130272/v1.pdf?c=1631881991000Direct OA link when available
- Concepts
-
Adipocyte, Paracrine signalling, Breast cancer, Adipose tissue, Cancer research, Cancer, Cancer cell, Medicine, Internal medicine, Inflammation, Biology, Immunology, Endocrinology, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
18Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3115225406 |
|---|---|
| doi | https://doi.org/10.21203/rs.3.rs-130272/v1 |
| ids.doi | https://doi.org/10.21203/rs.3.rs-130272/v1 |
| ids.mag | 3115225406 |
| ids.openalex | https://openalex.org/W3115225406 |
| fwci | 0.0 |
| type | preprint |
| title | Macrophage conditioned media promotes adipocyte cancer-association, which in turn stimulates breast cancer proliferation and migration |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10528 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9965000152587891 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2713 |
| topics[0].subfield.display_name | Epidemiology |
| topics[0].display_name | Adipokines, Inflammation, and Metabolic Diseases |
| topics[1].id | https://openalex.org/T11457 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.992900013923645 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2737 |
| topics[1].subfield.display_name | Physiology |
| topics[1].display_name | Adipose Tissue and Metabolism |
| topics[2].id | https://openalex.org/T12626 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9761999845504761 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2738 |
| topics[2].subfield.display_name | Psychiatry and Mental health |
| topics[2].display_name | Cancer, Stress, Anesthesia, and Immune Response |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2776175234 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7708349227905273 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q357519 |
| concepts[0].display_name | Adipocyte |
| concepts[1].id | https://openalex.org/C7876069 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7699185609817505 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q14873666 |
| concepts[1].display_name | Paracrine signalling |
| concepts[2].id | https://openalex.org/C530470458 |
| concepts[2].level | 3 |
| concepts[2].score | 0.7004693746566772 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q128581 |
| concepts[2].display_name | Breast cancer |
| concepts[3].id | https://openalex.org/C171089720 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5949486494064331 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q193583 |
| concepts[3].display_name | Adipose tissue |
| concepts[4].id | https://openalex.org/C502942594 |
| concepts[4].level | 1 |
| concepts[4].score | 0.5312181711196899 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[4].display_name | Cancer research |
| concepts[5].id | https://openalex.org/C121608353 |
| concepts[5].level | 2 |
| concepts[5].score | 0.4943079948425293 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[5].display_name | Cancer |
| concepts[6].id | https://openalex.org/C96232424 |
| concepts[6].level | 3 |
| concepts[6].score | 0.4783560633659363 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q4118072 |
| concepts[6].display_name | Cancer cell |
| concepts[7].id | https://openalex.org/C71924100 |
| concepts[7].level | 0 |
| concepts[7].score | 0.4599681496620178 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[7].display_name | Medicine |
| concepts[8].id | https://openalex.org/C126322002 |
| concepts[8].level | 1 |
| concepts[8].score | 0.43664291501045227 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[8].display_name | Internal medicine |
| concepts[9].id | https://openalex.org/C2776914184 |
| concepts[9].level | 2 |
| concepts[9].score | 0.43460309505462646 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[9].display_name | Inflammation |
| concepts[10].id | https://openalex.org/C86803240 |
| concepts[10].level | 0 |
| concepts[10].score | 0.3652764558792114 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[10].display_name | Biology |
| concepts[11].id | https://openalex.org/C203014093 |
| concepts[11].level | 1 |
| concepts[11].score | 0.3417041301727295 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[11].display_name | Immunology |
| concepts[12].id | https://openalex.org/C134018914 |
| concepts[12].level | 1 |
| concepts[12].score | 0.3245232105255127 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[12].display_name | Endocrinology |
| concepts[13].id | https://openalex.org/C170493617 |
| concepts[13].level | 2 |
| concepts[13].score | 0.07343095541000366 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[13].display_name | Receptor |
| keywords[0].id | https://openalex.org/keywords/adipocyte |
| keywords[0].score | 0.7708349227905273 |
| keywords[0].display_name | Adipocyte |
| keywords[1].id | https://openalex.org/keywords/paracrine-signalling |
| keywords[1].score | 0.7699185609817505 |
| keywords[1].display_name | Paracrine signalling |
| keywords[2].id | https://openalex.org/keywords/breast-cancer |
| keywords[2].score | 0.7004693746566772 |
| keywords[2].display_name | Breast cancer |
| keywords[3].id | https://openalex.org/keywords/adipose-tissue |
| keywords[3].score | 0.5949486494064331 |
| keywords[3].display_name | Adipose tissue |
| keywords[4].id | https://openalex.org/keywords/cancer-research |
| keywords[4].score | 0.5312181711196899 |
| keywords[4].display_name | Cancer research |
| keywords[5].id | https://openalex.org/keywords/cancer |
| keywords[5].score | 0.4943079948425293 |
| keywords[5].display_name | Cancer |
| keywords[6].id | https://openalex.org/keywords/cancer-cell |
| keywords[6].score | 0.4783560633659363 |
| keywords[6].display_name | Cancer cell |
| keywords[7].id | https://openalex.org/keywords/medicine |
| keywords[7].score | 0.4599681496620178 |
| keywords[7].display_name | Medicine |
| keywords[8].id | https://openalex.org/keywords/internal-medicine |
| keywords[8].score | 0.43664291501045227 |
| keywords[8].display_name | Internal medicine |
| keywords[9].id | https://openalex.org/keywords/inflammation |
| keywords[9].score | 0.43460309505462646 |
| keywords[9].display_name | Inflammation |
| keywords[10].id | https://openalex.org/keywords/biology |
| keywords[10].score | 0.3652764558792114 |
| keywords[10].display_name | Biology |
| keywords[11].id | https://openalex.org/keywords/immunology |
| keywords[11].score | 0.3417041301727295 |
| keywords[11].display_name | Immunology |
| keywords[12].id | https://openalex.org/keywords/endocrinology |
| keywords[12].score | 0.3245232105255127 |
| keywords[12].display_name | Endocrinology |
| keywords[13].id | https://openalex.org/keywords/receptor |
| keywords[13].score | 0.07343095541000366 |
| keywords[13].display_name | Receptor |
| language | en |
| locations[0].id | doi:10.21203/rs.3.rs-130272/v1 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402450 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Research Square (Research Square) |
| locations[0].source.host_organization | https://openalex.org/I4210096694 |
| locations[0].source.host_organization_name | Research Square (United States) |
| locations[0].source.host_organization_lineage | https://openalex.org/I4210096694 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.researchsquare.com/article/rs-130272/v1.pdf?c=1631881991000 |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.21203/rs.3.rs-130272/v1 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5057598971 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-2237-8509 |
| authorships[0].author.display_name | Karin A. Vallega |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I103163165 |
| authorships[0].affiliations[0].raw_affiliation_string | Florida State University |
| authorships[0].institutions[0].id | https://openalex.org/I103163165 |
| authorships[0].institutions[0].ror | https://ror.org/05g3dte14 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I103163165 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Florida State University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Karin A. Vallega |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Florida State University |
| authorships[1].author.id | https://openalex.org/A5082170009 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-3982-5056 |
| authorships[1].author.display_name | Dale B. Bosco |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I103163165 |
| authorships[1].affiliations[0].raw_affiliation_string | Florida State University |
| authorships[1].institutions[0].id | https://openalex.org/I103163165 |
| authorships[1].institutions[0].ror | https://ror.org/05g3dte14 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I103163165 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Florida State University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Dale B. Bosco |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Florida State University |
| authorships[2].author.id | https://openalex.org/A5015283451 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-0176-493X |
| authorships[2].author.display_name | Yi Ren |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I103163165 |
| authorships[2].affiliations[0].raw_affiliation_string | Florida State University |
| authorships[2].institutions[0].id | https://openalex.org/I103163165 |
| authorships[2].institutions[0].ror | https://ror.org/05g3dte14 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I103163165 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Florida State University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Yi Ren |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Florida State University |
| authorships[3].author.id | https://openalex.org/A5000775605 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-8828-0569 |
| authorships[3].author.display_name | Qing‐Xiang Amy Sang |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I103163165 |
| authorships[3].affiliations[0].raw_affiliation_string | Florida State University |
| authorships[3].institutions[0].id | https://openalex.org/I103163165 |
| authorships[3].institutions[0].ror | https://ror.org/05g3dte14 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I103163165 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Florida State University |
| authorships[3].author_position | last |
| authorships[3].raw_author_name | Qing-Xiang Sang |
| authorships[3].is_corresponding | True |
| authorships[3].raw_affiliation_strings | Florida State University |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.researchsquare.com/article/rs-130272/v1.pdf?c=1631881991000 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Macrophage conditioned media promotes adipocyte cancer-association, which in turn stimulates breast cancer proliferation and migration |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10528 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9965000152587891 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2713 |
| primary_topic.subfield.display_name | Epidemiology |
| primary_topic.display_name | Adipokines, Inflammation, and Metabolic Diseases |
| related_works | https://openalex.org/W2045047231, https://openalex.org/W106298747, https://openalex.org/W2067801294, https://openalex.org/W2211133357, https://openalex.org/W2944749008, https://openalex.org/W2891766348, https://openalex.org/W2027359065, https://openalex.org/W629568700, https://openalex.org/W3126307273, https://openalex.org/W2201571627 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.21203/rs.3.rs-130272/v1 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402450 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Research Square (Research Square) |
| best_oa_location.source.host_organization | https://openalex.org/I4210096694 |
| best_oa_location.source.host_organization_name | Research Square (United States) |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I4210096694 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.researchsquare.com/article/rs-130272/v1.pdf?c=1631881991000 |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-130272/v1 |
| primary_location.id | doi:10.21203/rs.3.rs-130272/v1 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402450 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Research Square (Research Square) |
| primary_location.source.host_organization | https://openalex.org/I4210096694 |
| primary_location.source.host_organization_name | Research Square (United States) |
| primary_location.source.host_organization_lineage | https://openalex.org/I4210096694 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.researchsquare.com/article/rs-130272/v1.pdf?c=1631881991000 |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-130272/v1 |
| publication_date | 2020-12-18 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2115226530, https://openalex.org/W2616570004, https://openalex.org/W2008869160, https://openalex.org/W1987237299, https://openalex.org/W2017703699, https://openalex.org/W1917407704, https://openalex.org/W2019399063, https://openalex.org/W2582686270, https://openalex.org/W2064237012, https://openalex.org/W2120071870, https://openalex.org/W2889189861, https://openalex.org/W2091482141, https://openalex.org/W2978066285, https://openalex.org/W4242190836, https://openalex.org/W1895025635, https://openalex.org/W1980916386, https://openalex.org/W4249727000, https://openalex.org/W639465351 |
| referenced_works_count | 18 |
| abstract_inverted_index.a | 26, 190 |
| abstract_inverted_index.An | 84 |
| abstract_inverted_index.As | 189 |
| abstract_inverted_index.In | 69 |
| abstract_inverted_index.in | 9, 58, 66, 171 |
| abstract_inverted_index.is | 4, 25, 37 |
| abstract_inverted_index.of | 15, 43, 56, 62, 74, 139, 155, 167, 174, 225 |
| abstract_inverted_index.on | 53, 77, 113 |
| abstract_inverted_index.to | 39, 92, 134, 144, 207, 244 |
| abstract_inverted_index.The | 111 |
| abstract_inverted_index.all | 185 |
| abstract_inverted_index.and | 11, 24, 33, 100, 104, 123, 142, 164, 202, 223, 238, 247, 249 |
| abstract_inverted_index.can | 107 |
| abstract_inverted_index.for | 29 |
| abstract_inverted_index.has | 51 |
| abstract_inverted_index.how | 105 |
| abstract_inverted_index.may | 242 |
| abstract_inverted_index.the | 5, 12, 54, 59, 72, 94, 136, 153, 172, 179 |
| abstract_inverted_index.was | 90, 132 |
| abstract_inverted_index.yet | 48 |
| abstract_inverted_index.More | 159 |
| abstract_inverted_index.cell | 87, 121, 187, 210, 236 |
| abstract_inverted_index.even | 170 |
| abstract_inverted_index.into | 45 |
| abstract_inverted_index.more | 197 |
| abstract_inverted_index.most | 6 |
| abstract_inverted_index.poor | 34 |
| abstract_inverted_index.risk | 27 |
| abstract_inverted_index.they | 106 |
| abstract_inverted_index.this | 70 |
| abstract_inverted_index.used | 91, 133 |
| abstract_inverted_index.were | 81, 118, 182 |
| abstract_inverted_index.when | 205 |
| abstract_inverted_index.with | 184, 199, 213 |
| abstract_inverted_index.These | 228 |
| abstract_inverted_index.Thus, | 240 |
| abstract_inverted_index.among | 97 |
| abstract_inverted_index.cause | 14 |
| abstract_inverted_index.cells | 117, 195 |
| abstract_inverted_index.chain | 129 |
| abstract_inverted_index.early | 60 |
| abstract_inverted_index.human | 86, 114, 233 |
| abstract_inverted_index.known | 38 |
| abstract_inverted_index.media | 151, 219 |
| abstract_inverted_index.model | 93 |
| abstract_inverted_index.obese | 67 |
| abstract_inverted_index.three | 186 |
| abstract_inverted_index.tumor | 64, 109 |
| abstract_inverted_index.using | 120 |
| abstract_inverted_index.women | 10 |
| abstract_inverted_index.Breast | 2 |
| abstract_inverted_index.became | 162, 196 |
| abstract_inverted_index.breast | 31, 63, 78, 101, 115, 156, 175, 193, 234, 251 |
| abstract_inverted_index.cancer | 3, 8, 17, 32, 102, 116, 176, 194, 209, 235, 252 |
| abstract_inverted_index.causes | 21 |
| abstract_inverted_index.cells, | 103, 177 |
| abstract_inverted_index.common | 7 |
| abstract_inverted_index.counts | 122 |
| abstract_inverted_index.deaths | 18 |
| abstract_inverted_index.factor | 28 |
| abstract_inverted_index.female | 16 |
| abstract_inverted_index.levels | 138, 181 |
| abstract_inverted_index.little | 49 |
| abstract_inverted_index.media. | 215 |
| abstract_inverted_index.stages | 61 |
| abstract_inverted_index.study, | 71 |
| abstract_inverted_index.system | 89 |
| abstract_inverted_index.Methods | 83 |
| abstract_inverted_index.Obesity | 20, 36 |
| abstract_inverted_index.Results | 148 |
| abstract_inverted_index.absence | 173 |
| abstract_inverted_index.adipose | 46 |
| abstract_inverted_index.analyze | 145 |
| abstract_inverted_index.assays. | 125 |
| abstract_inverted_index.chronic | 22 |
| abstract_inverted_index.effects | 55, 73, 112, 154 |
| abstract_inverted_index.focused | 52 |
| abstract_inverted_index.highest | 183 |
| abstract_inverted_index.leading | 13 |
| abstract_inverted_index.measure | 135 |
| abstract_inverted_index.promote | 232, 250 |
| abstract_inverted_index.result, | 191 |
| abstract_inverted_index.several | 140 |
| abstract_inverted_index.tissue, | 47 |
| abstract_inverted_index.treated | 212 |
| abstract_inverted_index.trigger | 40 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.although | 178 |
| abstract_inverted_index.compared | 206 |
| abstract_inverted_index.examined | 119 |
| abstract_inverted_index.factors. | 227 |
| abstract_inverted_index.promotes | 220 |
| abstract_inverted_index.reaction | 130 |
| abstract_inverted_index.research | 50 |
| abstract_inverted_index.(qRT-PCR) | 131 |
| abstract_inverted_index.adipocyte | 146, 221, 245 |
| abstract_inverted_index.crosstalk | 80 |
| abstract_inverted_index.cytokines | 141 |
| abstract_inverted_index.increased | 41, 165, 200 |
| abstract_inverted_index.migration | 124, 203 |
| abstract_inverted_index.paracrine | 95, 230 |
| abstract_inverted_index.patients. | 68 |
| abstract_inverted_index.potential | 204 |
| abstract_inverted_index.proteases | 143 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Macrophage | 149, 217 |
| abstract_inverted_index.adipocytes | 161 |
| abstract_inverted_index.co-culture | 88 |
| abstract_inverted_index.contribute | 243 |
| abstract_inverted_index.crosstalk. | 158 |
| abstract_inverted_index.cytokines, | 169 |
| abstract_inverted_index.expression | 137, 180 |
| abstract_inverted_index.facilitate | 108 |
| abstract_inverted_index.innovative | 85 |
| abstract_inverted_index.migration. | 239 |
| abstract_inverted_index.polymerase | 128 |
| abstract_inverted_index.production | 166, 224 |
| abstract_inverted_index.prognosis. | 35 |
| abstract_inverted_index.worldwide. | 19 |
| abstract_inverted_index.Conclusions | 216 |
| abstract_inverted_index.adipocytes, | 98 |
| abstract_inverted_index.aggressive, | 198 |
| abstract_inverted_index.co-cultured | 192 |
| abstract_inverted_index.co-cultures | 211 |
| abstract_inverted_index.components. | 188 |
| abstract_inverted_index.conditioned | 150, 218 |
| abstract_inverted_index.delipidated | 163 |
| abstract_inverted_index.development | 65 |
| abstract_inverted_index.intensified | 152 |
| abstract_inverted_index.macrophages | 44, 57, 76, 241 |
| abstract_inverted_index.Quantitative | 126 |
| abstract_inverted_index.infiltration | 42 |
| abstract_inverted_index.inflammation | 23, 246 |
| abstract_inverted_index.interactions | 96, 231 |
| abstract_inverted_index.macrophages, | 99 |
| abstract_inverted_index.progression. | 110, 253 |
| abstract_inverted_index.investigated. | 82 |
| abstract_inverted_index.proliferation | 201, 237 |
| abstract_inverted_index.specifically, | 160 |
| abstract_inverted_index.unconditioned | 214 |
| abstract_inverted_index.post-menopausal | 30 |
| abstract_inverted_index.adipocyte-breast | 208 |
| abstract_inverted_index.cancer-adipocyte | 79, 157 |
| abstract_inverted_index.pro-inflammatory | 75, 168, 226 |
| abstract_inverted_index.cancer-association | 222, 248 |
| abstract_inverted_index.cancer-association. | 147 |
| abstract_inverted_index.macrophage-adipocyte | 229 |
| abstract_inverted_index.reverse-transcription | 127 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5000775605 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| corresponding_institution_ids | https://openalex.org/I103163165 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5099999904632568 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.22014957 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |