Madecassoside Induces Apoptosis and Inhibits Migration by Regulating ROS ‐Mediated Signaling Pathways in MDA ‐ MB ‐231 Breast Cancer Cells
Article Swipe
Wen‐Shuang Hou
,
Ying‐Hua Luo
,
Nan Wu
,
Yan‐Jun Tang
,
Yanzhi Liu
,
Yanliang Zhang
,
Cheng‐Hao Jin
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/cbdd.70197
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/cbdd.70197
Madecassoside (MC) is an anti‐inflammatory and antibacterial active substance extracted from the traditional Chinese medicine Centella asiatica . Based on network pharmacology and experimental validation, this study assessed MC's anti‐breast cancer (BC) actions and related molecular pathways. CCK‐8, Trypan Blue, and Hoechst33342/PI assays showed that MC significantly reduced BC cell activity, but it had little inhibitory effects on normal cells. Network pharmacology analysis predicted 40 intersection targets between MC and BC, 291 GO‐related biological processes, and 105 KEGG signaling pathways. The anti‐breast cancer activity of MC is closely related to reactive oxygen species (ROS), AKT and MAPK signaling pathways. Through Annexin V‐FITC/PI, flow cytometry, transwell, wound healing and western blotting experiments, it was found that MC induced mitochondria‐dependent apoptosis, G2/M phase arrest and inhibited cell migration of MDA‐MB‐231 cells through MAPK/STAT3/NF‐κB signaling pathway, PI3K/AKT signaling pathway and AKT/GSK‐3β/β‐catenin signaling pathway, respectively. The induction and blocking effects were inhibited by the addition of ROS scavenger N‐acetyl cysteine (NAC). Molecular docking showed that MC had significant binding ability with STAT3, CASP3, BCL2 and JUN targets in BC. In summary, MC induced apoptosis, cell cycle arrest, and migration inhibition via ROS‐mediated MAPK/STAT3/NF‐κB, PI3K/AKT, and AKT/GSK‐3β/β‐catenin signaling pathways in MDA‐MB‐231 cells.
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- article
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- en
- Landing Page
- https://doi.org/10.1111/cbdd.70197
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cbdd.70197
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https://doi.org/10.1111/cbdd.70197Digital Object Identifier
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Madecassoside Induces Apoptosis and Inhibits Migration by Regulating
ROS ‐Mediated Signaling Pathways inMDA ‐MB ‐231 Breast Cancer CellsWork title - Type
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-11-01Full publication date if available
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Wen‐Shuang Hou, Ying‐Hua Luo, Nan Wu, Yan‐Jun Tang, Yanzhi Liu, Yanliang Zhang, Cheng‐Hao JinList of authors in order
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https://doi.org/10.1111/cbdd.70197Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cbdd.70197Direct link to full text PDF
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bronzeOpen access status per OpenAlex
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0Total citation count in OpenAlex
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| abstract_inverted_index.it | 53, 112 |
| abstract_inverted_index.of | 85, 127, 152 |
| abstract_inverted_index.on | 20, 58 |
| abstract_inverted_index.to | 90 |
| abstract_inverted_index.105 | 77 |
| abstract_inverted_index.291 | 72 |
| abstract_inverted_index.AKT | 95 |
| abstract_inverted_index.BC, | 71 |
| abstract_inverted_index.BC. | 175 |
| abstract_inverted_index.JUN | 172 |
| abstract_inverted_index.ROS | 153 |
| abstract_inverted_index.The | 81, 142 |
| abstract_inverted_index.and | 6, 23, 34, 41, 70, 76, 96, 108, 123, 137, 144, 171, 184, 191 |
| abstract_inverted_index.but | 52 |
| abstract_inverted_index.had | 54, 163 |
| abstract_inverted_index.the | 12, 150 |
| abstract_inverted_index.via | 187 |
| abstract_inverted_index.was | 113 |
| abstract_inverted_index.(BC) | 32 |
| abstract_inverted_index.(MC) | 2 |
| abstract_inverted_index.BCL2 | 170 |
| abstract_inverted_index.G2/M | 120 |
| abstract_inverted_index.KEGG | 78 |
| abstract_inverted_index.MAPK | 97 |
| abstract_inverted_index.MC's | 29 |
| abstract_inverted_index.cell | 50, 125, 181 |
| abstract_inverted_index.flow | 103 |
| abstract_inverted_index.from | 11 |
| abstract_inverted_index.that | 45, 115, 161 |
| abstract_inverted_index.this | 26 |
| abstract_inverted_index.were | 147 |
| abstract_inverted_index.with | 167 |
| abstract_inverted_index.Based | 19 |
| abstract_inverted_index.Blue, | 40 |
| abstract_inverted_index.cells | 129 |
| abstract_inverted_index.cycle | 182 |
| abstract_inverted_index.found | 114 |
| abstract_inverted_index.phase | 121 |
| abstract_inverted_index.study | 27 |
| abstract_inverted_index.wound | 106 |
| abstract_inverted_index.(NAC). | 157 |
| abstract_inverted_index.(ROS), | 94 |
| abstract_inverted_index.CASP3, | 169 |
| abstract_inverted_index.STAT3, | 168 |
| abstract_inverted_index.Trypan | 39 |
| abstract_inverted_index.active | 8 |
| abstract_inverted_index.arrest | 122 |
| abstract_inverted_index.assays | 43 |
| abstract_inverted_index.cancer | 31, 83 |
| abstract_inverted_index.cells. | 60, 197 |
| abstract_inverted_index.little | 55 |
| abstract_inverted_index.normal | 59 |
| abstract_inverted_index.oxygen | 92 |
| abstract_inverted_index.showed | 44, 160 |
| abstract_inverted_index.Annexin | 101 |
| abstract_inverted_index.Chinese | 14 |
| abstract_inverted_index.Network | 61 |
| abstract_inverted_index.Through | 100 |
| abstract_inverted_index.ability | 166 |
| abstract_inverted_index.actions | 33 |
| abstract_inverted_index.arrest, | 183 |
| abstract_inverted_index.between | 68 |
| abstract_inverted_index.binding | 165 |
| abstract_inverted_index.closely | 88 |
| abstract_inverted_index.docking | 159 |
| abstract_inverted_index.effects | 57, 146 |
| abstract_inverted_index.healing | 107 |
| abstract_inverted_index.induced | 117, 179 |
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| abstract_inverted_index.pathway | 136 |
| abstract_inverted_index.reduced | 48 |
| abstract_inverted_index.related | 35, 89 |
| abstract_inverted_index.species | 93 |
| abstract_inverted_index.targets | 67, 173 |
| abstract_inverted_index.through | 130 |
| abstract_inverted_index.western | 109 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.CCK‐8, | 38 |
| abstract_inverted_index.Centella | 16 |
| abstract_inverted_index.PI3K/AKT | 134 |
| abstract_inverted_index.activity | 84 |
| abstract_inverted_index.addition | 151 |
| abstract_inverted_index.analysis | 63 |
| abstract_inverted_index.asiatica | 17 |
| abstract_inverted_index.assessed | 28 |
| abstract_inverted_index.blocking | 145 |
| abstract_inverted_index.blotting | 110 |
| abstract_inverted_index.cysteine | 156 |
| abstract_inverted_index.medicine | 15 |
| abstract_inverted_index.pathway, | 133, 140 |
| abstract_inverted_index.pathways | 194 |
| abstract_inverted_index.reactive | 91 |
| abstract_inverted_index.summary, | 177 |
| abstract_inverted_index.Molecular | 158 |
| abstract_inverted_index.PI3K/AKT, | 190 |
| abstract_inverted_index.activity, | 51 |
| abstract_inverted_index.extracted | 10 |
| abstract_inverted_index.induction | 143 |
| abstract_inverted_index.inhibited | 124, 148 |
| abstract_inverted_index.migration | 126, 185 |
| abstract_inverted_index.molecular | 36 |
| abstract_inverted_index.pathways. | 37, 80, 99 |
| abstract_inverted_index.predicted | 64 |
| abstract_inverted_index.scavenger | 154 |
| abstract_inverted_index.signaling | 79, 98, 132, 135, 139, 193 |
| abstract_inverted_index.substance | 9 |
| abstract_inverted_index.N‐acetyl | 155 |
| abstract_inverted_index.apoptosis, | 119, 180 |
| abstract_inverted_index.biological | 74 |
| abstract_inverted_index.cytometry, | 104 |
| abstract_inverted_index.inhibition | 186 |
| abstract_inverted_index.inhibitory | 56 |
| abstract_inverted_index.processes, | 75 |
| abstract_inverted_index.transwell, | 105 |
| abstract_inverted_index.significant | 164 |
| abstract_inverted_index.traditional | 13 |
| abstract_inverted_index.validation, | 25 |
| abstract_inverted_index.GO‐related | 73 |
| abstract_inverted_index.V‐FITC/PI, | 102 |
| abstract_inverted_index.experimental | 24 |
| abstract_inverted_index.experiments, | 111 |
| abstract_inverted_index.intersection | 66 |
| abstract_inverted_index.pharmacology | 22, 62 |
| abstract_inverted_index.Madecassoside | 1 |
| abstract_inverted_index.antibacterial | 7 |
| abstract_inverted_index.anti‐breast | 30, 82 |
| abstract_inverted_index.respectively. | 141 |
| abstract_inverted_index.significantly | 47 |
| abstract_inverted_index.MDA‐MB‐231 | 128, 196 |
| abstract_inverted_index.ROS‐mediated | 188 |
| abstract_inverted_index.Hoechst33342/PI | 42 |
| abstract_inverted_index.MAPK/STAT3/NF‐κB | 131 |
| abstract_inverted_index.anti‐inflammatory | 5 |
| abstract_inverted_index.MAPK/STAT3/NF‐κB, | 189 |
| abstract_inverted_index.mitochondria‐dependent | 118 |
| abstract_inverted_index.AKT/GSK‐3β/β‐catenin | 138, 192 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5074837931, https://openalex.org/A5037222272 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I4210124184, https://openalex.org/I4210164133 |
| citation_normalized_percentile |