Magnetic resonance imaging determination of tissue sodium across the CKD spectrum – associations and implications for health Article Swipe
Kylie Martin
,
Vijay Venkatraman
,
Sven-Jean Tan
,
Timothy D. Hewitson
,
Patricia Robertson
,
Nigel D Toussaint
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/ckj/sfaf339
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/ckj/sfaf339
Background and Hypothesis Increased tissue sodium (Na+) concentration is associated with adverse clinical outcomes in people with chronic kidney disease (CKD) including hypertension, inflammation and increased cardiovascular disease (CVD). 23-sodium magnetic resonance imaging (23Na-MRI) can non-invasively quantify tissue Na+ concentration. However, in the CKD population, few studies have evaluated relationships between 23Na-MRI-derived tissue Na+ concentrations and measures of Na+ metabolism, surrogate markers of CVD and other CKD-related health complications. Methods We conducted a cross-sectional cohort study, involving 51 participants with CKD (28 with non-dialysis CKD, 23 on dialysis), to explore relationships between 23Na-MRI-derived tissue Na+ concentrations (including skin, bone, muscle and whole leg tissue), measures of Na+ metabolism and CKD-related health outcomes. Multivariable regression and correlation analyses were used to assess associations. Results Skin and whole leg tissue Na+ concentrations were positively associated with surrogate cardiovascular markers of troponin I and brain-natriuretic peptide (P < 0.05). Bone and whole leg tissue Na+ concentrations were negatively associated with bone mineral density. Higher muscle Na+ concentration was associated with lower levels of physical well-being. Tissue Na+ concentration was positively correlated with extracellular fluid volume as measured by proton (1H) MRI (P ≤ 0.001) and body composition monitor (P < 0.05). Conclusion Whole leg tissue Na+ in addition to skin Na+ concentration may be a useful clinical marker of body Na+ with related health outcomes. Tissue Na+ may play a role in CVD, bone health and quality of life in people with CKD, representing a potential therapeutic target to improve clinical outcomes.
Related Topics
Concepts
Medicine
Magnetic resonance imaging
Extracellular fluid
Muscle tissue
Kidney disease
Cohort
Adipose tissue
Surrogate endpoint
Pathology
Body water
Internal medicine
Cohort study
Soft tissue
Bone tissue
Inflammation
Biomarker
Bone remodeling
Sodium
Bone health
Sarcopenia
Microdialysis
Quality of life (healthcare)
Extracellular
Disease
Lean tissue
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ckj/sfaf339
- https://academic.oup.com/ckj/advance-article-pdf/doi/10.1093/ckj/sfaf339/65236897/sfaf339.pdf
- OA Status
- gold
- OpenAlex ID
- https://openalex.org/W7104438379
All OpenAlex metadata
Raw OpenAlex JSON
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- DOI
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https://doi.org/10.1093/ckj/sfaf339Digital Object Identifier
- Title
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Magnetic resonance imaging determination of tissue sodium across the CKD spectrum – associations and implications for healthWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-11-06Full publication date if available
- Authors
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Kylie Martin, Vijay Venkatraman, Sven-Jean Tan, Timothy D. Hewitson, Patricia Robertson, Nigel D ToussaintList of authors in order
- Landing page
-
https://doi.org/10.1093/ckj/sfaf339Publisher landing page
- PDF URL
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https://academic.oup.com/ckj/advance-article-pdf/doi/10.1093/ckj/sfaf339/65236897/sfaf339.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://academic.oup.com/ckj/advance-article-pdf/doi/10.1093/ckj/sfaf339/65236897/sfaf339.pdfDirect OA link when available
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Medicine, Magnetic resonance imaging, Extracellular fluid, Muscle tissue, Kidney disease, Cohort, Adipose tissue, Surrogate endpoint, Pathology, Body water, Internal medicine, Cohort study, Soft tissue, Bone tissue, Inflammation, Biomarker, Bone remodeling, Sodium, Bone health, Sarcopenia, Microdialysis, Quality of life (healthcare), Extracellular, Disease, Lean tissueTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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