Many Ways to the Cell Cycle Exit after Inhibition of CDK4/6 Article Swipe
Cyclin-dependent kinases (CDKs) are master regulators of proliferation, and therefore they represent attractive targets for cancer therapy. Development of selective CDK4/6 inhibitors including palbociclib revolutionized the treatment of advanced HR + /HER2 – breast cancer. Inhibition of CDK4/6 leads to cell cycle arrest in G0/G1 phase and eventually to a permanent cell cycle exit called senescence. One of the main features of the senescence is an increased cell size. For many years, it was believed that the non-dividing cells simply continue to grow and as a result, they become excessively large. There is now emerging evidence that the increased cell size is a cause rather than consequence of the cell cycle arrest. This review aims to summarize recent advances in our understanding of senescence induction, in particular that resulting from treatment with CDK4/6 inhibitors.
Related Topics
Concepts
Palbociclib
Cyclin-dependent kinase
Senescence
Cell cycle
Cell cycle progression
Restriction point
Cyclin
Cell cycle checkpoint
Cell growth
Cell biology
G1 phase
Kinase
Cell
Biology
Cancer research
Cancer
Breast cancer
Biochemistry
Genetics
Metastatic breast cancer
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.14712/fb2023069050194
- https://fb.littledata.cz/media/pdf/fb_2023069050194.pdf
- OA Status
- bronze
- Cited By
- 1
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4394064829
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4394064829Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.14712/fb2023069050194Digital Object Identifier
- Title
-
Many Ways to the Cell Cycle Exit after Inhibition of CDK4/6Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-01Full publication date if available
- Authors
-
Libor MacůrekList of authors in order
- Landing page
-
https://doi.org/10.14712/fb2023069050194Publisher landing page
- PDF URL
-
https://fb.littledata.cz/media/pdf/fb_2023069050194.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://fb.littledata.cz/media/pdf/fb_2023069050194.pdfDirect OA link when available
- Concepts
-
Palbociclib, Cyclin-dependent kinase, Senescence, Cell cycle, Cell cycle progression, Restriction point, Cyclin, Cell cycle checkpoint, Cell growth, Cell biology, G1 phase, Kinase, Cell, Biology, Cancer research, Cancer, Breast cancer, Biochemistry, Genetics, Metastatic breast cancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
25Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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