μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping Article Swipe
Sean W. Huth
,
James V. Oakley
,
Ciaran P. Seath
,
Jacob B. Geri
,
Aaron Trowbridge
,
Dann L. Parker
,
Frances P. Rodriguez‐Rivera
,
Adam G. Schwaid
,
Carlo P. Ramil
,
Keun Ah Ryu
,
Cory White
,
Olugbeminiyi Fadeyi
,
Rob Oslund
,
David W. C. MacMillan
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1021/jacs.3c03325
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1021/jacs.3c03325
The characterization of ligand binding modes is a crucial step in the drug discovery process and is especially important in campaigns arising from phenotypic screening, where the protein target and binding mode are unknown at the outset. Elucidation of target binding regions is typically achieved by X-ray crystallography or photoaffinity labeling (PAL) approaches; yet, these methods present significant challenges. X-ray crystallography is a mainstay technique that has revolutionized drug discovery, but in many cases structural characterization is challenging or impossible. PAL has also enabled binding site mapping with peptide- and amino-acid-level resolution; however, the stoichiometric activation mode can lead to poor signal and coverage of the resident binding pocket. Additionally, each PAL probe can have its own fragmentation pattern, complicating the analysis by mass spectrometry. Here, we establish a robust and general photocatalytic approach toward the mapping of protein binding sites, which we define as identification of residues proximal to the ligand binding pocket. By utilizing a catalytic mode of activation, we obtain sets of labeled amino acids in the proximity of the target protein binding site. We use this methodology to map, in vitro, the binding sites of six protein targets, including several kinases and molecular glue targets, and furthermore to investigate the binding site of the STAT3 inhibitor MM-206, a ligand with no known crystal structure. Finally, we demonstrate the successful mapping of drug binding sites in live cells. These results establish μMap as a powerful method for the generation of amino-acid- and peptide-level target engagement data.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/jacs.3c03325
- OA Status
- green
- Cited By
- 54
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4384925259
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4384925259Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1021/jacs.3c03325Digital Object Identifier
- Title
-
μMap Photoproximity Labeling Enables Small Molecule Binding Site MappingWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-07-20Full publication date if available
- Authors
-
Sean W. Huth, James V. Oakley, Ciaran P. Seath, Jacob B. Geri, Aaron Trowbridge, Dann L. Parker, Frances P. Rodriguez‐Rivera, Adam G. Schwaid, Carlo P. Ramil, Keun Ah Ryu, Cory White, Olugbeminiyi Fadeyi, Rob Oslund, David W. C. MacMillanList of authors in order
- Landing page
-
https://doi.org/10.1021/jacs.3c03325Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://pmc.ncbi.nlm.nih.gov/articles/PMC10809032/pdf/nihms-1955484.pdfDirect OA link when available
- Concepts
-
Chemistry, Binding site, Drug discovery, Small molecule, Ligand (biochemistry), Computational biology, Peptide, Amino acid, Target protein, Plasma protein binding, Combinatorial chemistry, Biochemistry, Receptor, Biology, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
54Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 28, 2024: 21, 2023: 5Per-year citation counts (last 5 years)
- References (count)
-
47Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4384925259 |
|---|---|
| doi | https://doi.org/10.1021/jacs.3c03325 |
| ids.doi | https://doi.org/10.1021/jacs.3c03325 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/37471577 |
| ids.openalex | https://openalex.org/W4384925259 |
| fwci | 10.41503851 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D008024 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Ligands |
| mesh[1].qualifier_ui | Q000737 |
| mesh[1].descriptor_ui | D011506 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | chemistry |
| mesh[1].descriptor_name | Proteins |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D001665 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Binding Sites |
| mesh[3].qualifier_ui | Q000737 |
| mesh[3].descriptor_ui | D010455 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | chemistry |
| mesh[3].descriptor_name | Peptides |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D011485 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Protein Binding |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D008024 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Ligands |
| mesh[6].qualifier_ui | Q000737 |
| mesh[6].descriptor_ui | D011506 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | chemistry |
| mesh[6].descriptor_name | Proteins |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D001665 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Binding Sites |
| mesh[8].qualifier_ui | Q000737 |
| mesh[8].descriptor_ui | D010455 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | chemistry |
| mesh[8].descriptor_name | Peptides |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D011485 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Protein Binding |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D008024 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Ligands |
| mesh[11].qualifier_ui | Q000737 |
| mesh[11].descriptor_ui | D011506 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | chemistry |
| mesh[11].descriptor_name | Proteins |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D001665 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Binding Sites |
| mesh[13].qualifier_ui | Q000737 |
| mesh[13].descriptor_ui | D010455 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | chemistry |
| mesh[13].descriptor_name | Peptides |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D011485 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Protein Binding |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D008024 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Ligands |
| mesh[16].qualifier_ui | Q000737 |
| mesh[16].descriptor_ui | D011506 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | chemistry |
| mesh[16].descriptor_name | Proteins |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D001665 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Binding Sites |
| mesh[18].qualifier_ui | Q000737 |
| mesh[18].descriptor_ui | D010455 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | chemistry |
| mesh[18].descriptor_name | Peptides |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D011485 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Protein Binding |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D008024 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Ligands |
| mesh[21].qualifier_ui | Q000737 |
| mesh[21].descriptor_ui | D011506 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | chemistry |
| mesh[21].descriptor_name | Proteins |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D001665 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Binding Sites |
| mesh[23].qualifier_ui | Q000737 |
| mesh[23].descriptor_ui | D010455 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | chemistry |
| mesh[23].descriptor_name | Peptides |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D011485 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Protein Binding |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D008024 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Ligands |
| mesh[26].qualifier_ui | Q000737 |
| mesh[26].descriptor_ui | D011506 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | chemistry |
| mesh[26].descriptor_name | Proteins |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D001665 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Binding Sites |
| mesh[28].qualifier_ui | Q000737 |
| mesh[28].descriptor_ui | D010455 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | chemistry |
| mesh[28].descriptor_name | Peptides |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D011485 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Protein Binding |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D008024 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Ligands |
| mesh[31].qualifier_ui | Q000737 |
| mesh[31].descriptor_ui | D011506 |
| mesh[31].is_major_topic | True |
| mesh[31].qualifier_name | chemistry |
| mesh[31].descriptor_name | Proteins |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D001665 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Binding Sites |
| mesh[33].qualifier_ui | Q000737 |
| mesh[33].descriptor_ui | D010455 |
| mesh[33].is_major_topic | True |
| mesh[33].qualifier_name | chemistry |
| mesh[33].descriptor_name | Peptides |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D011485 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Protein Binding |
| type | article |
| title | μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping |
| awards[0].id | https://openalex.org/G7295226226 |
| awards[0].funder_id | https://openalex.org/F4320337368 |
| awards[0].display_name | |
| awards[0].funder_award_id | DGE-1656466 |
| awards[0].funder_display_name | Division of Graduate Education |
| awards[1].id | https://openalex.org/G5176898874 |
| awards[1].funder_id | https://openalex.org/F4320337354 |
| awards[1].display_name | |
| awards[1].funder_award_id | R35-GM134897-02 |
| awards[1].funder_display_name | National Institute of General Medical Sciences |
| biblio.issue | 30 |
| biblio.volume | 145 |
| biblio.last_page | 16296 |
| biblio.first_page | 16289 |
| topics[0].id | https://openalex.org/T11440 |
| topics[0].field.id | https://openalex.org/fields/16 |
| topics[0].field.display_name | Chemistry |
| topics[0].score | 0.9990000128746033 |
| topics[0].domain.id | https://openalex.org/domains/3 |
| topics[0].domain.display_name | Physical Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1605 |
| topics[0].subfield.display_name | Organic Chemistry |
| topics[0].display_name | Click Chemistry and Applications |
| topics[1].id | https://openalex.org/T10911 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9976000189781189 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Chemical Synthesis and Analysis |
| topics[2].id | https://openalex.org/T12534 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9973999857902527 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Protein Degradation and Inhibitors |
| funders[0].id | https://openalex.org/F4320307115 |
| funders[0].ror | https://ror.org/00gtmwv55 |
| funders[0].display_name | Bristol-Myers Squibb |
| funders[1].id | https://openalex.org/F4320307758 |
| funders[1].ror | https://ror.org/01qat3289 |
| funders[1].display_name | Eli Lilly and Company |
| funders[2].id | https://openalex.org/F4320307765 |
| funders[2].ror | https://ror.org/01xdqrp08 |
| funders[2].display_name | Pfizer |
| funders[3].id | https://openalex.org/F4320307776 |
| funders[3].ror | https://ror.org/02891sr49 |
| funders[3].display_name | Merck |
| funders[4].id | https://openalex.org/F4320309292 |
| funders[4].ror | https://ror.org/00hx57361 |
| funders[4].display_name | Princeton University |
| funders[5].id | https://openalex.org/F4320332193 |
| funders[5].ror | https://ror.org/04gndp242 |
| funders[5].display_name | Genentech |
| funders[6].id | https://openalex.org/F4320337354 |
| funders[6].ror | https://ror.org/04q48ey07 |
| funders[6].display_name | National Institute of General Medical Sciences |
| funders[7].id | https://openalex.org/F4320337368 |
| funders[7].ror | https://ror.org/00whkrf32 |
| funders[7].display_name | Division of Graduate Education |
| funders[8].id | https://openalex.org/F4320337415 |
| funders[8].ror | https://ror.org/03qd7mz70 |
| funders[8].display_name | Janssen Research and Development |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C185592680 |
| concepts[0].level | 0 |
| concepts[0].score | 0.7936305999755859 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[0].display_name | Chemistry |
| concepts[1].id | https://openalex.org/C107824862 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6888677477836609 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q616005 |
| concepts[1].display_name | Binding site |
| concepts[2].id | https://openalex.org/C74187038 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6722957491874695 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1418791 |
| concepts[2].display_name | Drug discovery |
| concepts[3].id | https://openalex.org/C161624437 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5639507174491882 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1988322 |
| concepts[3].display_name | Small molecule |
| concepts[4].id | https://openalex.org/C116569031 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5139691233634949 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q899107 |
| concepts[4].display_name | Ligand (biochemistry) |
| concepts[5].id | https://openalex.org/C70721500 |
| concepts[5].level | 1 |
| concepts[5].score | 0.48695239424705505 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[5].display_name | Computational biology |
| concepts[6].id | https://openalex.org/C2779281246 |
| concepts[6].level | 2 |
| concepts[6].score | 0.45294636487960815 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q172847 |
| concepts[6].display_name | Peptide |
| concepts[7].id | https://openalex.org/C515207424 |
| concepts[7].level | 2 |
| concepts[7].score | 0.44196510314941406 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q8066 |
| concepts[7].display_name | Amino acid |
| concepts[8].id | https://openalex.org/C2780430158 |
| concepts[8].level | 3 |
| concepts[8].score | 0.43955257534980774 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7685902 |
| concepts[8].display_name | Target protein |
| concepts[9].id | https://openalex.org/C51639874 |
| concepts[9].level | 2 |
| concepts[9].score | 0.4108659327030182 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q167149 |
| concepts[9].display_name | Plasma protein binding |
| concepts[10].id | https://openalex.org/C21951064 |
| concepts[10].level | 1 |
| concepts[10].score | 0.3466799557209015 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q899212 |
| concepts[10].display_name | Combinatorial chemistry |
| concepts[11].id | https://openalex.org/C55493867 |
| concepts[11].level | 1 |
| concepts[11].score | 0.3312828540802002 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[11].display_name | Biochemistry |
| concepts[12].id | https://openalex.org/C170493617 |
| concepts[12].level | 2 |
| concepts[12].score | 0.1518940031528473 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[12].display_name | Receptor |
| concepts[13].id | https://openalex.org/C86803240 |
| concepts[13].level | 0 |
| concepts[13].score | 0.08602094650268555 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[13].display_name | Biology |
| concepts[14].id | https://openalex.org/C104317684 |
| concepts[14].level | 2 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[14].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/chemistry |
| keywords[0].score | 0.7936305999755859 |
| keywords[0].display_name | Chemistry |
| keywords[1].id | https://openalex.org/keywords/binding-site |
| keywords[1].score | 0.6888677477836609 |
| keywords[1].display_name | Binding site |
| keywords[2].id | https://openalex.org/keywords/drug-discovery |
| keywords[2].score | 0.6722957491874695 |
| keywords[2].display_name | Drug discovery |
| keywords[3].id | https://openalex.org/keywords/small-molecule |
| keywords[3].score | 0.5639507174491882 |
| keywords[3].display_name | Small molecule |
| keywords[4].id | https://openalex.org/keywords/ligand |
| keywords[4].score | 0.5139691233634949 |
| keywords[4].display_name | Ligand (biochemistry) |
| keywords[5].id | https://openalex.org/keywords/computational-biology |
| keywords[5].score | 0.48695239424705505 |
| keywords[5].display_name | Computational biology |
| keywords[6].id | https://openalex.org/keywords/peptide |
| keywords[6].score | 0.45294636487960815 |
| keywords[6].display_name | Peptide |
| keywords[7].id | https://openalex.org/keywords/amino-acid |
| keywords[7].score | 0.44196510314941406 |
| keywords[7].display_name | Amino acid |
| keywords[8].id | https://openalex.org/keywords/target-protein |
| keywords[8].score | 0.43955257534980774 |
| keywords[8].display_name | Target protein |
| keywords[9].id | https://openalex.org/keywords/plasma-protein-binding |
| keywords[9].score | 0.4108659327030182 |
| keywords[9].display_name | Plasma protein binding |
| keywords[10].id | https://openalex.org/keywords/combinatorial-chemistry |
| keywords[10].score | 0.3466799557209015 |
| keywords[10].display_name | Combinatorial chemistry |
| keywords[11].id | https://openalex.org/keywords/biochemistry |
| keywords[11].score | 0.3312828540802002 |
| keywords[11].display_name | Biochemistry |
| keywords[12].id | https://openalex.org/keywords/receptor |
| keywords[12].score | 0.1518940031528473 |
| keywords[12].display_name | Receptor |
| keywords[13].id | https://openalex.org/keywords/biology |
| keywords[13].score | 0.08602094650268555 |
| keywords[13].display_name | Biology |
| language | en |
| locations[0].id | doi:10.1021/jacs.3c03325 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S111155417 |
| locations[0].source.issn | 0002-7863, 1520-5126, 1943-2984 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0002-7863 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of the American Chemical Society |
| locations[0].source.host_organization | https://openalex.org/P4310320006 |
| locations[0].source.host_organization_name | American Chemical Society |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320006 |
| locations[0].source.host_organization_lineage_names | American Chemical Society |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of the American Chemical Society |
| locations[0].landing_page_url | https://doi.org/10.1021/jacs.3c03325 |
| locations[1].id | pmid:37471577 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of the American Chemical Society |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/37471577 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10809032 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10809032/pdf/nihms-1955484.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | J Am Chem Soc |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10809032 |
| locations[3].id | pmh:oai:pure.atira.dk:openaire_cris_publications/62aaeff8-7f82-45ee-9232-55db92684c79 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306400216 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Research Portal (King's College London) |
| locations[3].source.host_organization | https://openalex.org/I183935753 |
| locations[3].source.host_organization_name | King's College London |
| locations[3].source.host_organization_lineage | https://openalex.org/I183935753 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Huth, S, Oakley, J, Seath, C P, Geri, J B, Trowbridge, A, Parker, D L, Rodriguez-Rivera, F P, Schwaid, A G, Ramil, C, Ryu, K A, White, C H, Fadeyi, O O, Oslund, R C & Macmillan, D W C 2023, 'μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping', J. Am. Chem. Soc., vol. 145, no. 30, pp. 16289-16296. https://doi.org/10.1021/jacs.3c03325 |
| locations[3].landing_page_url | https://research.manchester.ac.uk/en/publications/62aaeff8-7f82-45ee-9232-55db92684c79 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5039315630 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-4892-2587 |
| authorships[0].author.display_name | Sean W. Huth |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I20089843 |
| authorships[0].affiliations[0].raw_affiliation_string | Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I20089843 |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States |
| authorships[0].institutions[0].id | https://openalex.org/I20089843 |
| authorships[0].institutions[0].ror | https://ror.org/00hx57361 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I20089843 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Princeton University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Sean W. Huth |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States, Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States |
| authorships[1].author.id | https://openalex.org/A5015550359 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-4774-5205 |
| authorships[1].author.display_name | James V. Oakley |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I20089843 |
| authorships[1].affiliations[0].raw_affiliation_string | Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I20089843 |
| authorships[1].affiliations[1].raw_affiliation_string | Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States |
| authorships[1].institutions[0].id | https://openalex.org/I20089843 |
| authorships[1].institutions[0].ror | https://ror.org/00hx57361 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I20089843 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Princeton University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | James V. Oakley |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States, Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States |
| authorships[2].author.id | https://openalex.org/A5006311746 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6774-128X |
| authorships[2].author.display_name | Ciaran P. Seath |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I20089843 |
| authorships[2].affiliations[0].raw_affiliation_string | Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I20089843 |
| authorships[2].affiliations[1].raw_affiliation_string | Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States |
| authorships[2].institutions[0].id | https://openalex.org/I20089843 |
| authorships[2].institutions[0].ror | https://ror.org/00hx57361 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I20089843 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Princeton University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Ciaran P. Seath |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States, Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States |
| authorships[3].author.id | https://openalex.org/A5080271854 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-9215-5610 |
| authorships[3].author.display_name | Jacob B. Geri |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I20089843 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I20089843 |
| authorships[3].affiliations[1].raw_affiliation_string | Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States |
| authorships[3].institutions[0].id | https://openalex.org/I20089843 |
| authorships[3].institutions[0].ror | https://ror.org/00hx57361 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I20089843 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Princeton University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jacob B. Geri |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States, Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States |
| authorships[4].author.id | https://openalex.org/A5006586854 |
| authorships[4].author.orcid | https://orcid.org/0009-0007-7252-462X |
| authorships[4].author.display_name | Aaron Trowbridge |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I20089843 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I20089843 |
| authorships[4].affiliations[1].raw_affiliation_string | Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States |
| authorships[4].institutions[0].id | https://openalex.org/I20089843 |
| authorships[4].institutions[0].ror | https://ror.org/00hx57361 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I20089843 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Princeton University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Aaron D. Trowbridge |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States, Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States |
| authorships[5].author.id | https://openalex.org/A5077495456 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-2338-4540 |
| authorships[5].author.display_name | Dann L. Parker |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I1285764155 |
| authorships[5].affiliations[0].raw_affiliation_string | Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States |
| authorships[5].institutions[0].id | https://openalex.org/I1285764155 |
| authorships[5].institutions[0].ror | https://ror.org/02891sr49 |
| authorships[5].institutions[0].type | company |
| authorships[5].institutions[0].lineage | https://openalex.org/I1285764155 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Merck & Co., Inc., Rahway, NJ, USA (United States) |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Dann L. Parker |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States |
| authorships[6].author.id | https://openalex.org/A5014628793 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-0651-8639 |
| authorships[6].author.display_name | Frances P. Rodriguez‐Rivera |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I1285764155 |
| authorships[6].affiliations[0].raw_affiliation_string | Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States |
| authorships[6].institutions[0].id | https://openalex.org/I1285764155 |
| authorships[6].institutions[0].ror | https://ror.org/02891sr49 |
| authorships[6].institutions[0].type | company |
| authorships[6].institutions[0].lineage | https://openalex.org/I1285764155 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Merck & Co., Inc., Rahway, NJ, USA (United States) |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Frances P. Rodriguez-Rivera |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States |
| authorships[7].author.id | https://openalex.org/A5034262609 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-2434-6148 |
| authorships[7].author.display_name | Adam G. Schwaid |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I1285764155 |
| authorships[7].affiliations[0].raw_affiliation_string | Discovery Chemistry, Merck & Co., Inc., Cambridge, Massachusetts 02141, United States |
| authorships[7].institutions[0].id | https://openalex.org/I1285764155 |
| authorships[7].institutions[0].ror | https://ror.org/02891sr49 |
| authorships[7].institutions[0].type | company |
| authorships[7].institutions[0].lineage | https://openalex.org/I1285764155 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Merck & Co., Inc., Rahway, NJ, USA (United States) |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Adam G. Schwaid |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Discovery Chemistry, Merck & Co., Inc., Cambridge, Massachusetts 02141, United States |
| authorships[8].author.id | https://openalex.org/A5051920818 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-1036-855X |
| authorships[8].author.display_name | Carlo P. Ramil |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I1285764155 |
| authorships[8].affiliations[0].raw_affiliation_string | Discovery Chemistry, Merck & Co., Inc., Cambridge, Massachusetts 02141, United States |
| authorships[8].institutions[0].id | https://openalex.org/I1285764155 |
| authorships[8].institutions[0].ror | https://ror.org/02891sr49 |
| authorships[8].institutions[0].type | company |
| authorships[8].institutions[0].lineage | https://openalex.org/I1285764155 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Merck & Co., Inc., Rahway, NJ, USA (United States) |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Carlo Ramil |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Discovery Chemistry, Merck & Co., Inc., Cambridge, Massachusetts 02141, United States |
| authorships[9].author.id | https://openalex.org/A5091564568 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-6244-0878 |
| authorships[9].author.display_name | Keun Ah Ryu |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I1285764155 |
| authorships[9].affiliations[0].raw_affiliation_string | Merck Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts 02141, United States |
| authorships[9].institutions[0].id | https://openalex.org/I1285764155 |
| authorships[9].institutions[0].ror | https://ror.org/02891sr49 |
| authorships[9].institutions[0].type | company |
| authorships[9].institutions[0].lineage | https://openalex.org/I1285764155 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Merck & Co., Inc., Rahway, NJ, USA (United States) |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Keun Ah Ryu |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Merck Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts 02141, United States |
| authorships[10].author.id | https://openalex.org/A5050000049 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-1619-0174 |
| authorships[10].author.display_name | Cory White |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I1285764155 |
| authorships[10].affiliations[0].raw_affiliation_string | Merck Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts 02141, United States |
| authorships[10].institutions[0].id | https://openalex.org/I1285764155 |
| authorships[10].institutions[0].ror | https://ror.org/02891sr49 |
| authorships[10].institutions[0].type | company |
| authorships[10].institutions[0].lineage | https://openalex.org/I1285764155 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | Merck & Co., Inc., Rahway, NJ, USA (United States) |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Cory H. White |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Merck Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts 02141, United States |
| authorships[11].author.id | https://openalex.org/A5037325947 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-5525-1304 |
| authorships[11].author.display_name | Olugbeminiyi Fadeyi |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I1285764155 |
| authorships[11].affiliations[0].raw_affiliation_string | Merck Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts 02141, United States |
| authorships[11].institutions[0].id | https://openalex.org/I1285764155 |
| authorships[11].institutions[0].ror | https://ror.org/02891sr49 |
| authorships[11].institutions[0].type | company |
| authorships[11].institutions[0].lineage | https://openalex.org/I1285764155 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | Merck & Co., Inc., Rahway, NJ, USA (United States) |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Olugbeminiyi O. Fadeyi |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Merck Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts 02141, United States |
| authorships[12].author.id | https://openalex.org/A5073194775 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-2920-9532 |
| authorships[12].author.display_name | Rob Oslund |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I1285764155 |
| authorships[12].affiliations[0].raw_affiliation_string | Merck Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts 02141, United States |
| authorships[12].institutions[0].id | https://openalex.org/I1285764155 |
| authorships[12].institutions[0].ror | https://ror.org/02891sr49 |
| authorships[12].institutions[0].type | company |
| authorships[12].institutions[0].lineage | https://openalex.org/I1285764155 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | Merck & Co., Inc., Rahway, NJ, USA (United States) |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Rob C. Oslund |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Merck Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts 02141, United States |
| authorships[13].author.id | https://openalex.org/A5025805979 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-6447-0587 |
| authorships[13].author.display_name | David W. C. MacMillan |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I20089843 |
| authorships[13].affiliations[0].raw_affiliation_string | Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States |
| authorships[13].affiliations[1].institution_ids | https://openalex.org/I20089843 |
| authorships[13].affiliations[1].raw_affiliation_string | Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States |
| authorships[13].institutions[0].id | https://openalex.org/I20089843 |
| authorships[13].institutions[0].ror | https://ror.org/00hx57361 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I20089843 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | Princeton University |
| authorships[13].author_position | last |
| authorships[13].raw_author_name | David W. C. MacMillan |
| authorships[13].is_corresponding | True |
| authorships[13].raw_affiliation_strings | Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States, Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10809032/pdf/nihms-1955484.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11440 |
| primary_topic.field.id | https://openalex.org/fields/16 |
| primary_topic.field.display_name | Chemistry |
| primary_topic.score | 0.9990000128746033 |
| primary_topic.domain.id | https://openalex.org/domains/3 |
| primary_topic.domain.display_name | Physical Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1605 |
| primary_topic.subfield.display_name | Organic Chemistry |
| primary_topic.display_name | Click Chemistry and Applications |
| related_works | https://openalex.org/W2043558654, https://openalex.org/W4225792090, https://openalex.org/W2090863707, https://openalex.org/W4385741417, https://openalex.org/W4285201319, https://openalex.org/W3143642740, https://openalex.org/W4285478100, https://openalex.org/W1570348606, https://openalex.org/W2167226024, https://openalex.org/W4214840794 |
| cited_by_count | 54 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 28 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 21 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 5 |
| locations_count | 4 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:10809032 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10809032/pdf/nihms-1955484.pdf |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | J Am Chem Soc |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10809032 |
| primary_location.id | doi:10.1021/jacs.3c03325 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S111155417 |
| primary_location.source.issn | 0002-7863, 1520-5126, 1943-2984 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0002-7863 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of the American Chemical Society |
| primary_location.source.host_organization | https://openalex.org/P4310320006 |
| primary_location.source.host_organization_name | American Chemical Society |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320006 |
| primary_location.source.host_organization_lineage_names | American Chemical Society |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of the American Chemical Society |
| primary_location.landing_page_url | https://doi.org/10.1021/jacs.3c03325 |
| publication_date | 2023-07-20 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W3047852223, https://openalex.org/W4282036924, https://openalex.org/W3061010776, https://openalex.org/W4211238337, https://openalex.org/W141181845, https://openalex.org/W2981180040, https://openalex.org/W3087769169, https://openalex.org/W3008730383, https://openalex.org/W2125384692, https://openalex.org/W2061098698, https://openalex.org/W3042332451, https://openalex.org/W2066736637, https://openalex.org/W4214945734, https://openalex.org/W2098539276, https://openalex.org/W3194825517, https://openalex.org/W3136460174, https://openalex.org/W2038252445, https://openalex.org/W2607236711, https://openalex.org/W2961046250, https://openalex.org/W2794389997, https://openalex.org/W2039220967, https://openalex.org/W3119123443, https://openalex.org/W2234585201, https://openalex.org/W2018272940, https://openalex.org/W2977373483, https://openalex.org/W4235541124, https://openalex.org/W3134329288, https://openalex.org/W2319267466, https://openalex.org/W4291804711, https://openalex.org/W2334045355, https://openalex.org/W2900884817, https://openalex.org/W2607310450, https://openalex.org/W2066713758, https://openalex.org/W1997952190, https://openalex.org/W2084427297, https://openalex.org/W4311927080, https://openalex.org/W2028544780, https://openalex.org/W3175064583, https://openalex.org/W2326318129, https://openalex.org/W2618875352, https://openalex.org/W2979382316, https://openalex.org/W3013865932, https://openalex.org/W2802520483, https://openalex.org/W4317802093, https://openalex.org/W3080123711, https://openalex.org/W2171948333, https://openalex.org/W96134817 |
| referenced_works_count | 47 |
| abstract_inverted_index.a | 7, 62, 128, 156, 211, 236 |
| abstract_inverted_index.By | 154 |
| abstract_inverted_index.We | 177 |
| abstract_inverted_index.as | 144, 235 |
| abstract_inverted_index.at | 34 |
| abstract_inverted_index.by | 45, 122 |
| abstract_inverted_index.in | 10, 19, 71, 168, 183, 228 |
| abstract_inverted_index.is | 6, 16, 42, 61, 76 |
| abstract_inverted_index.no | 214 |
| abstract_inverted_index.of | 2, 38, 104, 137, 146, 159, 164, 171, 188, 206, 224, 242 |
| abstract_inverted_index.or | 48, 78 |
| abstract_inverted_index.to | 99, 149, 181, 201 |
| abstract_inverted_index.we | 126, 142, 161, 219 |
| abstract_inverted_index.PAL | 80, 111 |
| abstract_inverted_index.The | 0 |
| abstract_inverted_index.and | 15, 29, 89, 102, 130, 195, 199, 244 |
| abstract_inverted_index.are | 32 |
| abstract_inverted_index.but | 70 |
| abstract_inverted_index.can | 97, 113 |
| abstract_inverted_index.for | 239 |
| abstract_inverted_index.has | 66, 81 |
| abstract_inverted_index.its | 115 |
| abstract_inverted_index.own | 116 |
| abstract_inverted_index.six | 189 |
| abstract_inverted_index.the | 11, 26, 35, 93, 105, 120, 135, 150, 169, 172, 185, 203, 207, 221, 240 |
| abstract_inverted_index.use | 178 |
| abstract_inverted_index.also | 82 |
| abstract_inverted_index.drug | 12, 68, 225 |
| abstract_inverted_index.each | 110 |
| abstract_inverted_index.from | 22 |
| abstract_inverted_index.glue | 197 |
| abstract_inverted_index.have | 114 |
| abstract_inverted_index.lead | 98 |
| abstract_inverted_index.live | 229 |
| abstract_inverted_index.many | 72 |
| abstract_inverted_index.map, | 182 |
| abstract_inverted_index.mass | 123 |
| abstract_inverted_index.mode | 31, 96, 158 |
| abstract_inverted_index.poor | 100 |
| abstract_inverted_index.sets | 163 |
| abstract_inverted_index.site | 85, 205 |
| abstract_inverted_index.step | 9 |
| abstract_inverted_index.that | 65 |
| abstract_inverted_index.this | 179 |
| abstract_inverted_index.with | 87, 213 |
| abstract_inverted_index.yet, | 53 |
| abstract_inverted_index.(PAL) | 51 |
| abstract_inverted_index.Here, | 125 |
| abstract_inverted_index.STAT3 | 208 |
| abstract_inverted_index.These | 231 |
| abstract_inverted_index.X-ray | 46, 59 |
| abstract_inverted_index.acids | 167 |
| abstract_inverted_index.amino | 166 |
| abstract_inverted_index.cases | 73 |
| abstract_inverted_index.data. | 248 |
| abstract_inverted_index.known | 215 |
| abstract_inverted_index.modes | 5 |
| abstract_inverted_index.probe | 112 |
| abstract_inverted_index.site. | 176 |
| abstract_inverted_index.sites | 187, 227 |
| abstract_inverted_index.these | 54 |
| abstract_inverted_index.where | 25 |
| abstract_inverted_index.which | 141 |
| abstract_inverted_index.μMap | 234 |
| abstract_inverted_index.cells. | 230 |
| abstract_inverted_index.define | 143 |
| abstract_inverted_index.ligand | 3, 151, 212 |
| abstract_inverted_index.method | 238 |
| abstract_inverted_index.obtain | 162 |
| abstract_inverted_index.robust | 129 |
| abstract_inverted_index.signal | 101 |
| abstract_inverted_index.sites, | 140 |
| abstract_inverted_index.target | 28, 39, 173, 246 |
| abstract_inverted_index.toward | 134 |
| abstract_inverted_index.vitro, | 184 |
| abstract_inverted_index.MM-206, | 210 |
| abstract_inverted_index.arising | 21 |
| abstract_inverted_index.binding | 4, 30, 40, 84, 107, 139, 152, 175, 186, 204, 226 |
| abstract_inverted_index.crucial | 8 |
| abstract_inverted_index.crystal | 216 |
| abstract_inverted_index.enabled | 83 |
| abstract_inverted_index.general | 131 |
| abstract_inverted_index.kinases | 194 |
| abstract_inverted_index.labeled | 165 |
| abstract_inverted_index.mapping | 86, 136, 223 |
| abstract_inverted_index.methods | 55 |
| abstract_inverted_index.outset. | 36 |
| abstract_inverted_index.pocket. | 108, 153 |
| abstract_inverted_index.present | 56 |
| abstract_inverted_index.process | 14 |
| abstract_inverted_index.protein | 27, 138, 174, 190 |
| abstract_inverted_index.regions | 41 |
| abstract_inverted_index.results | 232 |
| abstract_inverted_index.several | 193 |
| abstract_inverted_index.unknown | 33 |
| abstract_inverted_index.Finally, | 218 |
| abstract_inverted_index.achieved | 44 |
| abstract_inverted_index.analysis | 121 |
| abstract_inverted_index.approach | 133 |
| abstract_inverted_index.coverage | 103 |
| abstract_inverted_index.however, | 92 |
| abstract_inverted_index.labeling | 50 |
| abstract_inverted_index.mainstay | 63 |
| abstract_inverted_index.pattern, | 118 |
| abstract_inverted_index.peptide- | 88 |
| abstract_inverted_index.powerful | 237 |
| abstract_inverted_index.proximal | 148 |
| abstract_inverted_index.resident | 106 |
| abstract_inverted_index.residues | 147 |
| abstract_inverted_index.targets, | 191, 198 |
| abstract_inverted_index.campaigns | 20 |
| abstract_inverted_index.catalytic | 157 |
| abstract_inverted_index.discovery | 13 |
| abstract_inverted_index.establish | 127, 233 |
| abstract_inverted_index.important | 18 |
| abstract_inverted_index.including | 192 |
| abstract_inverted_index.inhibitor | 209 |
| abstract_inverted_index.molecular | 196 |
| abstract_inverted_index.proximity | 170 |
| abstract_inverted_index.technique | 64 |
| abstract_inverted_index.typically | 43 |
| abstract_inverted_index.utilizing | 155 |
| abstract_inverted_index.activation | 95 |
| abstract_inverted_index.discovery, | 69 |
| abstract_inverted_index.engagement | 247 |
| abstract_inverted_index.especially | 17 |
| abstract_inverted_index.generation | 241 |
| abstract_inverted_index.phenotypic | 23 |
| abstract_inverted_index.screening, | 24 |
| abstract_inverted_index.structural | 74 |
| abstract_inverted_index.structure. | 217 |
| abstract_inverted_index.successful | 222 |
| abstract_inverted_index.Elucidation | 37 |
| abstract_inverted_index.activation, | 160 |
| abstract_inverted_index.amino-acid- | 243 |
| abstract_inverted_index.approaches; | 52 |
| abstract_inverted_index.challenges. | 58 |
| abstract_inverted_index.challenging | 77 |
| abstract_inverted_index.demonstrate | 220 |
| abstract_inverted_index.furthermore | 200 |
| abstract_inverted_index.impossible. | 79 |
| abstract_inverted_index.investigate | 202 |
| abstract_inverted_index.methodology | 180 |
| abstract_inverted_index.resolution; | 91 |
| abstract_inverted_index.significant | 57 |
| abstract_inverted_index.complicating | 119 |
| abstract_inverted_index.Additionally, | 109 |
| abstract_inverted_index.fragmentation | 117 |
| abstract_inverted_index.peptide-level | 245 |
| abstract_inverted_index.photoaffinity | 49 |
| abstract_inverted_index.spectrometry. | 124 |
| abstract_inverted_index.identification | 145 |
| abstract_inverted_index.photocatalytic | 132 |
| abstract_inverted_index.revolutionized | 67 |
| abstract_inverted_index.stoichiometric | 94 |
| abstract_inverted_index.crystallography | 47, 60 |
| abstract_inverted_index.amino-acid-level | 90 |
| abstract_inverted_index.characterization | 1, 75 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5025805979 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 14 |
| corresponding_institution_ids | https://openalex.org/I20089843 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7599999904632568 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.98872836 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |