Mapping antibody footprints using binding profiles Article Swipe
A. Azulay
,
Liel Cohen-Lavi
,
Lilach M. Friedman
,
Maureen A. McGargill
,
Tomer Hertz
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.crmeth.2023.100566
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.crmeth.2023.100566
The increasing use of monoclonal antibodies (mAbs) in biology and medicine necessitates efficient methods for characterizing their binding epitopes. Here, we developed a high-throughput antibody footprinting method based on binding profiles. We used an antigen microarray to profile 23 human anti-influenza hemagglutinin (HA) mAbs using HA proteins of 43 human influenza strains isolated between 1918 and 2018. We showed that the mAb's binding profile can be used to characterize its influenza subtype specificity, binding region, and binding site. We present mAb-Patch-an epitope prediction method that is based on a mAb's binding profile and the 3D structure of its antigen. mAb-Patch was evaluated using four mAbs with known solved mAb-HA structures. mAb-Patch identifies over 67% of the true epitope when considering only 50-60 positions along the antigen. Our work provides proof of concept for utilizing antibody binding profiles to screen large panels of mAbs and to down-select antibodies for further functional studies.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.crmeth.2023.100566
- OA Status
- gold
- Cited By
- 4
- References
- 104
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386074698
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386074698Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.crmeth.2023.100566Digital Object Identifier
- Title
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Mapping antibody footprints using binding profilesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-08-01Full publication date if available
- Authors
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A. Azulay, Liel Cohen-Lavi, Lilach M. Friedman, Maureen A. McGargill, Tomer HertzList of authors in order
- Landing page
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https://doi.org/10.1016/j.crmeth.2023.100566Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.crmeth.2023.100566Direct OA link when available
- Concepts
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Epitope, Monoclonal antibody, Epitope mapping, Antibody, Antigen, Hemagglutinin (influenza), Computational biology, Molecular biology, Binding site, Virology, Chemistry, Biology, Biochemistry, ImmunologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
- References (count)
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104Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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