Mapping functional elements of the DNA damage response through base editor screens Article Swipe
Qian Pan
,
Zhixuan Zhang
,
Yiwei Xiong
,
Ying Bao
,
Tianxin Chen
,
Ping Xu
,
Zhiheng Liu
,
Huazheng Ma
,
Ying Yu
,
Zhuo Zhou
,
Wensheng Wei
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2024.115047
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2024.115047
Maintaining genomic stability is vital for cellular equilibrium. In this study, we combined CRISPR-mediated base editing with pooled screening technologies to identify numerous mutations in lysine residues and protein-coding genes. The loss of these lysine residues and genes resulted in either sensitivity or resistance to DNA-damaging agents. Among the identified variants, we characterized both loss-of-function and gain-of-function mutations in response to DNA damage. Notably, we discovered that the K494 mutation of C17orf53 disrupts its interaction with RPA proteins, leading to increased sensitivity to cisplatin. Additionally, our analysis identified STK35 as a previously unrecognized gene involved in DNA damage response (DDR) pathways, suggesting that it may play a critical role in DNA repair. We believe that this resource will offer valuable insights into the broader functions of DNA damage response genes and accelerate research on variants relevant to cancer therapy.
Related Topics
Concepts
DNA damage
Biology
Gene
DNA repair
CRISPR
DNA
Genetics
Functional genomics
Mutation
Loss function
Function (biology)
Computational biology
Mutagenesis
genomic DNA
Phenotype
Genomics
Genome
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.celrep.2024.115047
- OA Status
- gold
- Cited By
- 1
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405248373
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405248373Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.celrep.2024.115047Digital Object Identifier
- Title
-
Mapping functional elements of the DNA damage response through base editor screensWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-01Full publication date if available
- Authors
-
Qian Pan, Zhixuan Zhang, Yiwei Xiong, Ying Bao, Tianxin Chen, Ping Xu, Zhiheng Liu, Huazheng Ma, Ying Yu, Zhuo Zhou, Wensheng WeiList of authors in order
- Landing page
-
https://doi.org/10.1016/j.celrep.2024.115047Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.celrep.2024.115047Direct OA link when available
- Concepts
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DNA damage, Biology, Gene, DNA repair, CRISPR, DNA, Genetics, Functional genomics, Mutation, Loss function, Function (biology), Computational biology, Mutagenesis, genomic DNA, Phenotype, Genomics, GenomeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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62Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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