Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI Article Swipe
Joonas A. Autio
,
Ikko Kimura
,
Takayuki Ose
,
Yuki Matsumoto
,
Masahiro Ohno
,
Yuta Urushibata
,
Takuro Ikeda
,
Matthew F. Glasser
,
David C. Van Essen
,
Takuya Hayashi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7554/elife.99940.4
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7554/elife.99940.4
Mapping the vascular organization of the brain is of great importance across various domains of basic neuroimaging research, diagnostic radiology, and neurology. However, the intricate task of precisely mapping vasculature across brain regions and cortical layers presents formidable challenges, resulting in a limited understanding of neurometabolic factors influencing the brain’s microvasculature. Addressing this gap, our study investigates whole-brain vascular volume using ferumoxytol-weighted laminar-resolution multi-echo gradient-echo imaging in macaque monkeys. We validate the results with published data for vascular densities and compare them with cytoarchitecture, neuron and synaptic densities. The ferumoxytol-induced change in transverse relaxation rate (ΔR 2 *), an indirect proxy measure of cerebral blood volume (CBV), was mapped onto 12 equivolumetric laminar cortical surfaces. Our findings reveal that CBV varies threefold across the brain, with the highest vascular volume observed in the inferior colliculus and lowest in the corpus callosum. In the cerebral cortex, CBV is notably high in early primary sensory areas and low in association areas responsible for higher cognitive functions. Classification of CBV into distinct groups unveils extensive replication of translaminar vascular network motifs, suggesting distinct computational energy supply requirements in areas with varying cytoarchitecture types. Regionally, baseline R 2 * and CBV exhibit positive correlations with neuron density and negative correlations with receptor densities. Adjusting image resolution based on the critical sampling frequency of penetrating cortical vessels allows us to delineate approximately 30% of the arterial–venous vessels. Collectively, these results mark significant methodological and conceptual advancements, contributing to the refinement of cerebrovascular MRI. Furthermore, our study establishes a linkage between neurometabolic factors and the vascular network architecture in the primate brain.
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- Type
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- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.99940.4
- OA Status
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- References
- 106
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- OpenAlex ID
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https://openalex.org/W4411214068Canonical identifier for this work in OpenAlex
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https://doi.org/10.7554/elife.99940.4Digital Object Identifier
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Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRIWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-06-11Full publication date if available
- Authors
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Joonas A. Autio, Ikko Kimura, Takayuki Ose, Yuki Matsumoto, Masahiro Ohno, Yuta Urushibata, Takuro Ikeda, Matthew F. Glasser, David C. Van Essen, Takuya HayashiList of authors in order
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https://doi.org/10.7554/elife.99940.4Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.7554/elife.99940.4Direct OA link when available
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Ferumoxytol, Vascular network, Primate, Magnetic resonance imaging, Neuroscience, Biology, Medicine, Anatomy, RadiologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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