MAPT-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis Article Swipe

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M Itsuno , Hirokazu Tanabe , Etsuko Sano , Takashi Sasaki , C Oyama , Hiroko Bannai , Koichi Saito , Kazuhiko Nakata , Setsu Endoh‐Yamagami , Hideyuki Okano , Sumihiro Maeda ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1016/j.reth.2024.12.009

Related Topics

Biology

Mutation

Neuroscience

Excitatory Postsynaptic Potential

Cell Biology

Alzheimer's Disease

Medicine

Proto-Oncogene Tyrosine-Protein Kinase Src

Internal Medicine

Disease

Embryonic Stem Cell

Concepts

FYN Biology Mutation Premovement neuronal activity Tau protein Induced pluripotent stem cell Neuroscience Excitatory postsynaptic potential Inhibitory postsynaptic potential Cell biology Alzheimer's disease Genetics Signal transduction Gene Medicine Proto-oncogene tyrosine-protein kinase Src Internal medicine Disease Embryonic stem cell

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.reth.2024.12.009
OA Status: gold
Cited By: 2
References: 58
Related Works: 10
OpenAlex ID: https://openalex.org/W4405742281

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DOI: https://doi.org/10.1016/j.reth.2024.12.009

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Title: MAPT-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis

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Language: en

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Publication year: 2024

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Publication date: 2024-12-24

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Authors: M Itsuno, Hirokazu Tanabe, Etsuko Sano, Takashi Sasaki, C Oyama, Hiroko Bannai, Koichi Saito, Kazuhiko Nakata, Setsu Endoh‐Yamagami, Hideyuki Okano, Sumihiro Maeda

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Landing page: https://doi.org/10.1016/j.reth.2024.12.009

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Concepts: FYN, Biology, Mutation, Premovement neuronal activity, Tau protein, Induced pluripotent stem cell, Neuroscience, Excitatory postsynaptic potential, Inhibitory postsynaptic potential, Cell biology, Alzheimer's disease, Genetics, Signal transduction, Gene, Medicine, Proto-oncogene tyrosine-protein kinase Src, Internal medicine, Disease, Embryonic stem cell

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Cited by: 2

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Citations by year (recent): 2025: 2

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References (count): 58

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Related works (count): 10

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