Marek’s disease virus protein kinase US3 inhibits DNA-sensing antiviral innate immunity via abrogating activation of NF-κB Article Swipe
Kai Li
,
Rui Liu
,
Yongzhen Liu
,
Li Gao
,
Changjun Liu
,
Yanping Zhang
,
Xiaole Qi
,
Hongyu Cui
,
Suyan Wang
,
Yuntong Chen
,
Yulu Duan
,
Yulong Gao
,
Xiaomei Wang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1128/spectrum.02347-24
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1128/spectrum.02347-24
Marek’s disease virus (MDV) is an avian alphaherpesvirus associated with Marek’s disease, an immunosuppressive and lymphoproliferative disease in chickens. The DNA sensing pathway mediates innate immune defense against infection by many DNA-containing pathogens, while viruses have evolved multiple strategies to evade the host immune response to survive in host cells. This study found that ectopic expression of MDV protein kinase US3 inhibited beta interferon (IFN-β) and interleukin-6 (IL-6) production induced by interferon-stimulatory and viral DNA. US3 was further shown to abolish the nuclear factor κB (NF-κB) activation. The US3 kinase activity was indispensable for its inhibitory function, as the kinase-dead US3 mutant (US3K220A) did not inhibit NF-κB activation. Further studies showed that US3 interacted with the Rel homology domains of the NF-κB subunits p65 and p50, which phosphorylated these transcription factors and blocked their nuclear translocation. Finally, US3 deficiency promoted IFN-β and IL-6 production, resulting in reduced viral replication and lower MDV-specific lesion incidence during MDV infection in chickens. Altogether, these findings reveal a novel mechanism for MDV to evade host antiviral immunity. IMPORTANCE Marek’s disease virus (MDV) is an oncogenic avian alphaherpesvirus that causes an economically important disease affecting the health and welfare of poultry worldwide. Whereas human herpesviruses have been shown to evolve various strategies to inhibit the DNA sensing signaling for the evasion of the host’s innate immunity, little is known regarding the mechanism for MDV to regulate this pathway. In this study, MDV US3 protein kinase was demonstrated to inhibit the activation of NF-κB in the DNA sensing pathway via binding to the Rel homology domains of the NF-κB subunits p65 and p50, which hyperphosphorylated these transcription factors and abolished their nuclear translocation. This is an important finding toward a better understanding of the functions of avian alphaherpesviruses encoded US3 protein kinase.
Related Topics
Concepts
Innate immune system
Virology
Protein kinase R
Immunity
Virus
Biology
Disease
NF-κB
Kinase
Immunology
Immune system
Protein kinase A
Cell biology
Medicine
Mitogen-activated protein kinase kinase
Inflammation
Pathology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/spectrum.02347-24
- OA Status
- gold
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408220088
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4408220088Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1128/spectrum.02347-24Digital Object Identifier
- Title
-
Marek’s disease virus protein kinase US3 inhibits DNA-sensing antiviral innate immunity via abrogating activation of NF-κBWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-05Full publication date if available
- Authors
-
Kai Li, Rui Liu, Yongzhen Liu, Li Gao, Changjun Liu, Yanping Zhang, Xiaole Qi, Hongyu Cui, Suyan Wang, Yuntong Chen, Yulu Duan, Yulong Gao, Xiaomei WangList of authors in order
- Landing page
-
https://doi.org/10.1128/spectrum.02347-24Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1128/spectrum.02347-24Direct OA link when available
- Concepts
-
Innate immune system, Virology, Protein kinase R, Immunity, Virus, Biology, Disease, NF-κB, Kinase, Immunology, Immune system, Protein kinase A, Cell biology, Medicine, Mitogen-activated protein kinase kinase, Inflammation, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
57Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4408220088 |
|---|---|
| doi | https://doi.org/10.1128/spectrum.02347-24 |
| ids.doi | https://doi.org/10.1128/spectrum.02347-24 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40042340 |
| ids.openalex | https://openalex.org/W4408220088 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D007113 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Immunity, Innate |
| mesh[2].qualifier_ui | Q000276 |
| mesh[2].descriptor_ui | D002645 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | immunology |
| mesh[2].descriptor_name | Chickens |
| mesh[3].qualifier_ui | Q000378 |
| mesh[3].descriptor_ui | D016328 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | metabolism |
| mesh[3].descriptor_name | NF-kappa B |
| mesh[4].qualifier_ui | Q000276 |
| mesh[4].descriptor_ui | D016328 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | immunology |
| mesh[4].descriptor_name | NF-kappa B |
| mesh[5].qualifier_ui | Q000235 |
| mesh[5].descriptor_ui | D016328 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | genetics |
| mesh[5].descriptor_name | NF-kappa B |
| mesh[6].qualifier_ui | Q000276 |
| mesh[6].descriptor_ui | D008380 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | immunology |
| mesh[6].descriptor_name | Marek Disease |
| mesh[7].qualifier_ui | Q000821 |
| mesh[7].descriptor_ui | D008380 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | virology |
| mesh[7].descriptor_name | Marek Disease |
| mesh[8].qualifier_ui | Q000276 |
| mesh[8].descriptor_ui | D008381 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | immunology |
| mesh[8].descriptor_name | Herpesvirus 2, Gallid |
| mesh[9].qualifier_ui | Q000235 |
| mesh[9].descriptor_ui | D008381 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | genetics |
| mesh[9].descriptor_name | Herpesvirus 2, Gallid |
| mesh[10].qualifier_ui | Q000235 |
| mesh[10].descriptor_ui | D014764 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | genetics |
| mesh[10].descriptor_name | Viral Proteins |
| mesh[11].qualifier_ui | Q000378 |
| mesh[11].descriptor_ui | D014764 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | metabolism |
| mesh[11].descriptor_name | Viral Proteins |
| mesh[12].qualifier_ui | Q000276 |
| mesh[12].descriptor_ui | D014764 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | immunology |
| mesh[12].descriptor_name | Viral Proteins |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D015850 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Interleukin-6 |
| mesh[14].qualifier_ui | Q000276 |
| mesh[14].descriptor_ui | D015850 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | immunology |
| mesh[14].descriptor_name | Interleukin-6 |
| mesh[15].qualifier_ui | Q000235 |
| mesh[15].descriptor_ui | D015850 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | genetics |
| mesh[15].descriptor_name | Interleukin-6 |
| mesh[16].qualifier_ui | Q000276 |
| mesh[16].descriptor_ui | D016899 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | immunology |
| mesh[16].descriptor_name | Interferon-beta |
| mesh[17].qualifier_ui | Q000235 |
| mesh[17].descriptor_ui | D016899 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | genetics |
| mesh[17].descriptor_name | Interferon-beta |
| mesh[18].qualifier_ui | Q000378 |
| mesh[18].descriptor_ui | D016899 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | metabolism |
| mesh[18].descriptor_name | Interferon-beta |
| mesh[19].qualifier_ui | Q000235 |
| mesh[19].descriptor_ui | D004279 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | genetics |
| mesh[19].descriptor_name | DNA, Viral |
| mesh[20].qualifier_ui | Q000276 |
| mesh[20].descriptor_ui | D004279 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | immunology |
| mesh[20].descriptor_name | DNA, Viral |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D006801 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Humans |
| mesh[22].qualifier_ui | Q000276 |
| mesh[22].descriptor_ui | D015398 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | immunology |
| mesh[22].descriptor_name | Signal Transduction |
| mesh[23].qualifier_ui | Q000821 |
| mesh[23].descriptor_ui | D011201 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | virology |
| mesh[23].descriptor_name | Poultry Diseases |
| mesh[24].qualifier_ui | Q000276 |
| mesh[24].descriptor_ui | D011201 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | immunology |
| mesh[24].descriptor_name | Poultry Diseases |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D010766 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Phosphorylation |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D000818 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Animals |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D007113 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Immunity, Innate |
| mesh[28].qualifier_ui | Q000378 |
| mesh[28].descriptor_ui | D016328 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | metabolism |
| mesh[28].descriptor_name | NF-kappa B |
| mesh[29].qualifier_ui | Q000276 |
| mesh[29].descriptor_ui | D016328 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | immunology |
| mesh[29].descriptor_name | NF-kappa B |
| mesh[30].qualifier_ui | Q000235 |
| mesh[30].descriptor_ui | D016328 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | genetics |
| mesh[30].descriptor_name | NF-kappa B |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D002645 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Chickens |
| mesh[32].qualifier_ui | Q000821 |
| mesh[32].descriptor_ui | D008380 |
| mesh[32].is_major_topic | True |
| mesh[32].qualifier_name | virology |
| mesh[32].descriptor_name | Marek Disease |
| mesh[33].qualifier_ui | Q000276 |
| mesh[33].descriptor_ui | D008380 |
| mesh[33].is_major_topic | True |
| mesh[33].qualifier_name | immunology |
| mesh[33].descriptor_name | Marek Disease |
| mesh[34].qualifier_ui | Q000378 |
| mesh[34].descriptor_ui | D016899 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | metabolism |
| mesh[34].descriptor_name | Interferon-beta |
| mesh[35].qualifier_ui | Q000276 |
| mesh[35].descriptor_ui | D016899 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | immunology |
| mesh[35].descriptor_name | Interferon-beta |
| mesh[36].qualifier_ui | Q000201 |
| mesh[36].descriptor_ui | D008381 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | enzymology |
| mesh[36].descriptor_name | Herpesvirus 2, Gallid |
| mesh[37].qualifier_ui | Q000276 |
| mesh[37].descriptor_ui | D008381 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | immunology |
| mesh[37].descriptor_name | Herpesvirus 2, Gallid |
| mesh[38].qualifier_ui | Q000235 |
| mesh[38].descriptor_ui | D008381 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | genetics |
| mesh[38].descriptor_name | Herpesvirus 2, Gallid |
| mesh[39].qualifier_ui | Q000235 |
| mesh[39].descriptor_ui | D014764 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | genetics |
| mesh[39].descriptor_name | Viral Proteins |
| mesh[40].qualifier_ui | Q000378 |
| mesh[40].descriptor_ui | D014764 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | metabolism |
| mesh[40].descriptor_name | Viral Proteins |
| mesh[41].qualifier_ui | Q000276 |
| mesh[41].descriptor_ui | D014764 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | immunology |
| mesh[41].descriptor_name | Viral Proteins |
| mesh[42].qualifier_ui | Q000378 |
| mesh[42].descriptor_ui | D015850 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | metabolism |
| mesh[42].descriptor_name | Interleukin-6 |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D014779 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | Virus Replication |
| mesh[44].qualifier_ui | Q000276 |
| mesh[44].descriptor_ui | D004279 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | immunology |
| mesh[44].descriptor_name | DNA, Viral |
| mesh[45].qualifier_ui | Q000235 |
| mesh[45].descriptor_ui | D017346 |
| mesh[45].is_major_topic | True |
| mesh[45].qualifier_name | genetics |
| mesh[45].descriptor_name | Protein Serine-Threonine Kinases |
| mesh[46].qualifier_ui | Q000378 |
| mesh[46].descriptor_ui | D017346 |
| mesh[46].is_major_topic | True |
| mesh[46].qualifier_name | metabolism |
| mesh[46].descriptor_name | Protein Serine-Threonine Kinases |
| mesh[47].qualifier_ui | Q000276 |
| mesh[47].descriptor_ui | D017346 |
| mesh[47].is_major_topic | True |
| mesh[47].qualifier_name | immunology |
| mesh[47].descriptor_name | Protein Serine-Threonine Kinases |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D002460 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Cell Line |
| mesh[49].qualifier_ui | |
| mesh[49].descriptor_ui | D015398 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | |
| mesh[49].descriptor_name | Signal Transduction |
| type | article |
| title | Marek’s disease virus protein kinase US3 inhibits DNA-sensing antiviral innate immunity via abrogating activation of NF-κB |
| biblio.issue | 4 |
| biblio.volume | 13 |
| biblio.last_page | e0234724 |
| biblio.first_page | e0234724 |
| grants[0].funder | https://openalex.org/F4320321001 |
| grants[0].award_id | 32270154 |
| grants[0].funder_display_name | National Natural Science Foundation of China |
| grants[1].funder | https://openalex.org/F4320327608 |
| grants[1].award_id | CARS-41-G15 |
| grants[1].funder_display_name | China Agricultural Research System |
| topics[0].id | https://openalex.org/T10625 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9997000098228455 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2713 |
| topics[0].subfield.display_name | Epidemiology |
| topics[0].display_name | Herpesvirus Infections and Treatments |
| topics[1].id | https://openalex.org/T11668 |
| topics[1].field.id | https://openalex.org/fields/24 |
| topics[1].field.display_name | Immunology and Microbiology |
| topics[1].score | 0.9994000196456909 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2403 |
| topics[1].subfield.display_name | Immunology |
| topics[1].display_name | interferon and immune responses |
| topics[2].id | https://openalex.org/T11112 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9937999844551086 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2705 |
| topics[2].subfield.display_name | Cardiology and Cardiovascular Medicine |
| topics[2].display_name | Viral Infections and Immunology Research |
| funders[0].id | https://openalex.org/F4320321001 |
| funders[0].ror | https://ror.org/01h0zpd94 |
| funders[0].display_name | National Natural Science Foundation of China |
| funders[1].id | https://openalex.org/F4320327608 |
| funders[1].ror | |
| funders[1].display_name | China Agricultural Research System |
| is_xpac | False |
| apc_list.value | 2500 |
| apc_list.currency | USD |
| apc_list.value_usd | 2500 |
| apc_paid.value | 2500 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2500 |
| concepts[0].id | https://openalex.org/C136449434 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8301084637641907 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q428253 |
| concepts[0].display_name | Innate immune system |
| concepts[1].id | https://openalex.org/C159047783 |
| concepts[1].level | 1 |
| concepts[1].score | 0.6754209995269775 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7215 |
| concepts[1].display_name | Virology |
| concepts[2].id | https://openalex.org/C161238802 |
| concepts[2].level | 5 |
| concepts[2].score | 0.6185542941093445 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q14905690 |
| concepts[2].display_name | Protein kinase R |
| concepts[3].id | https://openalex.org/C2779341262 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5600423812866211 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q182581 |
| concepts[3].display_name | Immunity |
| concepts[4].id | https://openalex.org/C2522874641 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5332821011543274 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q808 |
| concepts[4].display_name | Virus |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.49028947949409485 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C2779134260 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4228888750076294 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[6].display_name | Disease |
| concepts[7].id | https://openalex.org/C2777730290 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4112117886543274 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q411114 |
| concepts[7].display_name | NF-κB |
| concepts[8].id | https://openalex.org/C184235292 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4108024537563324 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q421851 |
| concepts[8].display_name | Kinase |
| concepts[9].id | https://openalex.org/C203014093 |
| concepts[9].level | 1 |
| concepts[9].score | 0.36599093675613403 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[9].display_name | Immunology |
| concepts[10].id | https://openalex.org/C8891405 |
| concepts[10].level | 2 |
| concepts[10].score | 0.35912907123565674 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[10].display_name | Immune system |
| concepts[11].id | https://openalex.org/C97029542 |
| concepts[11].level | 3 |
| concepts[11].score | 0.2725587487220764 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q281417 |
| concepts[11].display_name | Protein kinase A |
| concepts[12].id | https://openalex.org/C95444343 |
| concepts[12].level | 1 |
| concepts[12].score | 0.19901958107948303 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[12].display_name | Cell biology |
| concepts[13].id | https://openalex.org/C71924100 |
| concepts[13].level | 0 |
| concepts[13].score | 0.18880125880241394 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[13].display_name | Medicine |
| concepts[14].id | https://openalex.org/C90934575 |
| concepts[14].level | 4 |
| concepts[14].score | 0.15660443902015686 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q6593810 |
| concepts[14].display_name | Mitogen-activated protein kinase kinase |
| concepts[15].id | https://openalex.org/C2776914184 |
| concepts[15].level | 2 |
| concepts[15].score | 0.1469832956790924 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[15].display_name | Inflammation |
| concepts[16].id | https://openalex.org/C142724271 |
| concepts[16].level | 1 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[16].display_name | Pathology |
| keywords[0].id | https://openalex.org/keywords/innate-immune-system |
| keywords[0].score | 0.8301084637641907 |
| keywords[0].display_name | Innate immune system |
| keywords[1].id | https://openalex.org/keywords/virology |
| keywords[1].score | 0.6754209995269775 |
| keywords[1].display_name | Virology |
| keywords[2].id | https://openalex.org/keywords/protein-kinase-r |
| keywords[2].score | 0.6185542941093445 |
| keywords[2].display_name | Protein kinase R |
| keywords[3].id | https://openalex.org/keywords/immunity |
| keywords[3].score | 0.5600423812866211 |
| keywords[3].display_name | Immunity |
| keywords[4].id | https://openalex.org/keywords/virus |
| keywords[4].score | 0.5332821011543274 |
| keywords[4].display_name | Virus |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.49028947949409485 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/disease |
| keywords[6].score | 0.4228888750076294 |
| keywords[6].display_name | Disease |
| keywords[7].id | https://openalex.org/keywords/nf-κb |
| keywords[7].score | 0.4112117886543274 |
| keywords[7].display_name | NF-κB |
| keywords[8].id | https://openalex.org/keywords/kinase |
| keywords[8].score | 0.4108024537563324 |
| keywords[8].display_name | Kinase |
| keywords[9].id | https://openalex.org/keywords/immunology |
| keywords[9].score | 0.36599093675613403 |
| keywords[9].display_name | Immunology |
| keywords[10].id | https://openalex.org/keywords/immune-system |
| keywords[10].score | 0.35912907123565674 |
| keywords[10].display_name | Immune system |
| keywords[11].id | https://openalex.org/keywords/protein-kinase-a |
| keywords[11].score | 0.2725587487220764 |
| keywords[11].display_name | Protein kinase A |
| keywords[12].id | https://openalex.org/keywords/cell-biology |
| keywords[12].score | 0.19901958107948303 |
| keywords[12].display_name | Cell biology |
| keywords[13].id | https://openalex.org/keywords/medicine |
| keywords[13].score | 0.18880125880241394 |
| keywords[13].display_name | Medicine |
| keywords[14].id | https://openalex.org/keywords/mitogen-activated-protein-kinase-kinase |
| keywords[14].score | 0.15660443902015686 |
| keywords[14].display_name | Mitogen-activated protein kinase kinase |
| keywords[15].id | https://openalex.org/keywords/inflammation |
| keywords[15].score | 0.1469832956790924 |
| keywords[15].display_name | Inflammation |
| language | en |
| locations[0].id | doi:10.1128/spectrum.02347-24 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2764766708 |
| locations[0].source.issn | 2165-0497 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2165-0497 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Microbiology Spectrum |
| locations[0].source.host_organization | https://openalex.org/P4310320263 |
| locations[0].source.host_organization_name | American Society for Microbiology |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320263 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Microbiology Spectrum |
| locations[0].landing_page_url | https://doi.org/10.1128/spectrum.02347-24 |
| locations[1].id | pmid:40042340 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Microbiology spectrum |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40042340 |
| locations[2].id | pmh:oai:europepmc.org:10773838 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11960123 |
| locations[3].id | pmh:oai:doaj.org/article:a2e00680458c4c1db76ff6ff38e28665 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Microbiology Spectrum, Vol 13, Iss 4 (2025) |
| locations[3].landing_page_url | https://doaj.org/article/a2e00680458c4c1db76ff6ff38e28665 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5100399863 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1746-7913 |
| authorships[0].author.display_name | Kai Li |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210138501, https://openalex.org/I72212903 |
| authorships[0].affiliations[0].raw_affiliation_string | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[0].affiliations[1].raw_affiliation_string | Chengdu National Agricultural Science and Technology Center, Chengdu, China |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I4210138501 |
| authorships[0].affiliations[2].raw_affiliation_string | Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu, China |
| authorships[0].institutions[0].id | https://openalex.org/I4210138501 |
| authorships[0].institutions[0].ror | https://ror.org/0313jb750 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Chinese Academy of Agricultural Sciences |
| authorships[0].institutions[1].id | https://openalex.org/I72212903 |
| authorships[0].institutions[1].ror | https://ror.org/034e92n57 |
| authorships[0].institutions[1].type | facility |
| authorships[0].institutions[1].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987, https://openalex.org/I72212903 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | Harbin Veterinary Research Institute |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Kai Li |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China, Chengdu National Agricultural Science and Technology Center, Chengdu, China, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu, China |
| authorships[1].author.id | https://openalex.org/A5100448485 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-4547-8695 |
| authorships[1].author.display_name | Rui Liu |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210138501, https://openalex.org/I72212903 |
| authorships[1].affiliations[0].raw_affiliation_string | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[1].institutions[0].id | https://openalex.org/I4210138501 |
| authorships[1].institutions[0].ror | https://ror.org/0313jb750 |
| authorships[1].institutions[0].type | government |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Chinese Academy of Agricultural Sciences |
| authorships[1].institutions[1].id | https://openalex.org/I72212903 |
| authorships[1].institutions[1].ror | https://ror.org/034e92n57 |
| authorships[1].institutions[1].type | facility |
| authorships[1].institutions[1].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987, https://openalex.org/I72212903 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | Harbin Veterinary Research Institute |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Rui Liu |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[2].author.id | https://openalex.org/A5101729207 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-5003-1484 |
| authorships[2].author.display_name | Yongzhen Liu |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210138501, https://openalex.org/I72212903 |
| authorships[2].affiliations[0].raw_affiliation_string | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[2].institutions[0].id | https://openalex.org/I4210138501 |
| authorships[2].institutions[0].ror | https://ror.org/0313jb750 |
| authorships[2].institutions[0].type | government |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Chinese Academy of Agricultural Sciences |
| authorships[2].institutions[1].id | https://openalex.org/I72212903 |
| authorships[2].institutions[1].ror | https://ror.org/034e92n57 |
| authorships[2].institutions[1].type | facility |
| authorships[2].institutions[1].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987, https://openalex.org/I72212903 |
| authorships[2].institutions[1].country_code | CN |
| authorships[2].institutions[1].display_name | Harbin Veterinary Research Institute |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Yongzhen Liu |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[3].author.id | https://openalex.org/A5068548000 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-4916-5346 |
| authorships[3].author.display_name | Li Gao |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210138501, https://openalex.org/I72212903 |
| authorships[3].affiliations[0].raw_affiliation_string | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[3].institutions[0].id | https://openalex.org/I4210138501 |
| authorships[3].institutions[0].ror | https://ror.org/0313jb750 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Chinese Academy of Agricultural Sciences |
| authorships[3].institutions[1].id | https://openalex.org/I72212903 |
| authorships[3].institutions[1].ror | https://ror.org/034e92n57 |
| authorships[3].institutions[1].type | facility |
| authorships[3].institutions[1].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987, https://openalex.org/I72212903 |
| authorships[3].institutions[1].country_code | CN |
| authorships[3].institutions[1].display_name | Harbin Veterinary Research Institute |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Li Gao |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[4].author.id | https://openalex.org/A5115596243 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Changjun Liu |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210138501, https://openalex.org/I72212903 |
| authorships[4].affiliations[0].raw_affiliation_string | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[4].institutions[0].id | https://openalex.org/I4210138501 |
| authorships[4].institutions[0].ror | https://ror.org/0313jb750 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Chinese Academy of Agricultural Sciences |
| authorships[4].institutions[1].id | https://openalex.org/I72212903 |
| authorships[4].institutions[1].ror | https://ror.org/034e92n57 |
| authorships[4].institutions[1].type | facility |
| authorships[4].institutions[1].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987, https://openalex.org/I72212903 |
| authorships[4].institutions[1].country_code | CN |
| authorships[4].institutions[1].display_name | Harbin Veterinary Research Institute |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Changjun Liu |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[5].author.id | https://openalex.org/A5100430700 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-8802-045X |
| authorships[5].author.display_name | Yanping Zhang |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210138501, https://openalex.org/I72212903 |
| authorships[5].affiliations[0].raw_affiliation_string | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[5].institutions[0].id | https://openalex.org/I4210138501 |
| authorships[5].institutions[0].ror | https://ror.org/0313jb750 |
| authorships[5].institutions[0].type | government |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Chinese Academy of Agricultural Sciences |
| authorships[5].institutions[1].id | https://openalex.org/I72212903 |
| authorships[5].institutions[1].ror | https://ror.org/034e92n57 |
| authorships[5].institutions[1].type | facility |
| authorships[5].institutions[1].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987, https://openalex.org/I72212903 |
| authorships[5].institutions[1].country_code | CN |
| authorships[5].institutions[1].display_name | Harbin Veterinary Research Institute |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Yanping Zhang |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[6].author.id | https://openalex.org/A5101811007 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-1874-0387 |
| authorships[6].author.display_name | Xiaole Qi |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210138501, https://openalex.org/I72212903 |
| authorships[6].affiliations[0].raw_affiliation_string | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[6].institutions[0].id | https://openalex.org/I4210138501 |
| authorships[6].institutions[0].ror | https://ror.org/0313jb750 |
| authorships[6].institutions[0].type | government |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Chinese Academy of Agricultural Sciences |
| authorships[6].institutions[1].id | https://openalex.org/I72212903 |
| authorships[6].institutions[1].ror | https://ror.org/034e92n57 |
| authorships[6].institutions[1].type | facility |
| authorships[6].institutions[1].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987, https://openalex.org/I72212903 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | Harbin Veterinary Research Institute |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Xiaole Qi |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[7].author.id | https://openalex.org/A5070093964 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-1432-9814 |
| authorships[7].author.display_name | Hongyu Cui |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210138501, https://openalex.org/I72212903 |
| authorships[7].affiliations[0].raw_affiliation_string | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[7].institutions[0].id | https://openalex.org/I4210138501 |
| authorships[7].institutions[0].ror | https://ror.org/0313jb750 |
| authorships[7].institutions[0].type | government |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Chinese Academy of Agricultural Sciences |
| authorships[7].institutions[1].id | https://openalex.org/I72212903 |
| authorships[7].institutions[1].ror | https://ror.org/034e92n57 |
| authorships[7].institutions[1].type | facility |
| authorships[7].institutions[1].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987, https://openalex.org/I72212903 |
| authorships[7].institutions[1].country_code | CN |
| authorships[7].institutions[1].display_name | Harbin Veterinary Research Institute |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Hongyu Cui |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[8].author.id | https://openalex.org/A5110709730 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Suyan Wang |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210138501, https://openalex.org/I72212903 |
| authorships[8].affiliations[0].raw_affiliation_string | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[8].institutions[0].id | https://openalex.org/I4210138501 |
| authorships[8].institutions[0].ror | https://ror.org/0313jb750 |
| authorships[8].institutions[0].type | government |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Chinese Academy of Agricultural Sciences |
| authorships[8].institutions[1].id | https://openalex.org/I72212903 |
| authorships[8].institutions[1].ror | https://ror.org/034e92n57 |
| authorships[8].institutions[1].type | facility |
| authorships[8].institutions[1].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987, https://openalex.org/I72212903 |
| authorships[8].institutions[1].country_code | CN |
| authorships[8].institutions[1].display_name | Harbin Veterinary Research Institute |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Suyan Wang |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[9].author.id | https://openalex.org/A5035002982 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-2433-609X |
| authorships[9].author.display_name | Yuntong Chen |
| authorships[9].countries | CN |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210138501, https://openalex.org/I72212903 |
| authorships[9].affiliations[0].raw_affiliation_string | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[9].institutions[0].id | https://openalex.org/I4210138501 |
| authorships[9].institutions[0].ror | https://ror.org/0313jb750 |
| authorships[9].institutions[0].type | government |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987 |
| authorships[9].institutions[0].country_code | CN |
| authorships[9].institutions[0].display_name | Chinese Academy of Agricultural Sciences |
| authorships[9].institutions[1].id | https://openalex.org/I72212903 |
| authorships[9].institutions[1].ror | https://ror.org/034e92n57 |
| authorships[9].institutions[1].type | facility |
| authorships[9].institutions[1].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987, https://openalex.org/I72212903 |
| authorships[9].institutions[1].country_code | CN |
| authorships[9].institutions[1].display_name | Harbin Veterinary Research Institute |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Yuntong Chen |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[10].author.id | https://openalex.org/A5021938820 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Yulu Duan |
| authorships[10].countries | CN |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I4210138501, https://openalex.org/I72212903 |
| authorships[10].affiliations[0].raw_affiliation_string | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[10].institutions[0].id | https://openalex.org/I4210138501 |
| authorships[10].institutions[0].ror | https://ror.org/0313jb750 |
| authorships[10].institutions[0].type | government |
| authorships[10].institutions[0].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987 |
| authorships[10].institutions[0].country_code | CN |
| authorships[10].institutions[0].display_name | Chinese Academy of Agricultural Sciences |
| authorships[10].institutions[1].id | https://openalex.org/I72212903 |
| authorships[10].institutions[1].ror | https://ror.org/034e92n57 |
| authorships[10].institutions[1].type | facility |
| authorships[10].institutions[1].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987, https://openalex.org/I72212903 |
| authorships[10].institutions[1].country_code | CN |
| authorships[10].institutions[1].display_name | Harbin Veterinary Research Institute |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Yulu Duan |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[11].author.id | https://openalex.org/A5026008293 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-0448-8467 |
| authorships[11].author.display_name | Yulong Gao |
| authorships[11].countries | CN |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I4210138501, https://openalex.org/I72212903 |
| authorships[11].affiliations[0].raw_affiliation_string | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[11].institutions[0].id | https://openalex.org/I4210138501 |
| authorships[11].institutions[0].ror | https://ror.org/0313jb750 |
| authorships[11].institutions[0].type | government |
| authorships[11].institutions[0].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987 |
| authorships[11].institutions[0].country_code | CN |
| authorships[11].institutions[0].display_name | Chinese Academy of Agricultural Sciences |
| authorships[11].institutions[1].id | https://openalex.org/I72212903 |
| authorships[11].institutions[1].ror | https://ror.org/034e92n57 |
| authorships[11].institutions[1].type | facility |
| authorships[11].institutions[1].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987, https://openalex.org/I72212903 |
| authorships[11].institutions[1].country_code | CN |
| authorships[11].institutions[1].display_name | Harbin Veterinary Research Institute |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Yulong Gao |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[12].author.id | https://openalex.org/A5100457078 |
| authorships[12].author.orcid | https://orcid.org/0000-0001-7411-9184 |
| authorships[12].author.display_name | Xiaomei Wang |
| authorships[12].countries | CN |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I78978612 |
| authorships[12].affiliations[0].raw_affiliation_string | Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou University, Yangzhou, China |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I4210138501, https://openalex.org/I72212903 |
| authorships[12].affiliations[1].raw_affiliation_string | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China |
| authorships[12].institutions[0].id | https://openalex.org/I4210138501 |
| authorships[12].institutions[0].ror | https://ror.org/0313jb750 |
| authorships[12].institutions[0].type | government |
| authorships[12].institutions[0].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987 |
| authorships[12].institutions[0].country_code | CN |
| authorships[12].institutions[0].display_name | Chinese Academy of Agricultural Sciences |
| authorships[12].institutions[1].id | https://openalex.org/I72212903 |
| authorships[12].institutions[1].ror | https://ror.org/034e92n57 |
| authorships[12].institutions[1].type | facility |
| authorships[12].institutions[1].lineage | https://openalex.org/I4210127390, https://openalex.org/I4210138501, https://openalex.org/I4210151987, https://openalex.org/I72212903 |
| authorships[12].institutions[1].country_code | CN |
| authorships[12].institutions[1].display_name | Harbin Veterinary Research Institute |
| authorships[12].institutions[2].id | https://openalex.org/I78978612 |
| authorships[12].institutions[2].ror | https://ror.org/03tqb8s11 |
| authorships[12].institutions[2].type | education |
| authorships[12].institutions[2].lineage | https://openalex.org/I78978612 |
| authorships[12].institutions[2].country_code | CN |
| authorships[12].institutions[2].display_name | Yangzhou University |
| authorships[12].author_position | last |
| authorships[12].raw_author_name | Xiaomei Wang |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou University, Yangzhou, China |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1128/spectrum.02347-24 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Marek’s disease virus protein kinase US3 inhibits DNA-sensing antiviral innate immunity via abrogating activation of NF-κB |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10625 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9997000098228455 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2713 |
| primary_topic.subfield.display_name | Epidemiology |
| primary_topic.display_name | Herpesvirus Infections and Treatments |
| related_works | https://openalex.org/W2272662053, https://openalex.org/W4401025635, https://openalex.org/W2041809495, https://openalex.org/W2641756084, https://openalex.org/W4367396980, https://openalex.org/W2089479565, https://openalex.org/W2156083701, https://openalex.org/W2951000707, https://openalex.org/W2027286159, https://openalex.org/W2085767188 |
| cited_by_count | 0 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1128/spectrum.02347-24 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764766708 |
| best_oa_location.source.issn | 2165-0497 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2165-0497 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Microbiology Spectrum |
| best_oa_location.source.host_organization | https://openalex.org/P4310320263 |
| best_oa_location.source.host_organization_name | American Society for Microbiology |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320263 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Microbiology Spectrum |
| best_oa_location.landing_page_url | https://doi.org/10.1128/spectrum.02347-24 |
| primary_location.id | doi:10.1128/spectrum.02347-24 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2764766708 |
| primary_location.source.issn | 2165-0497 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2165-0497 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Microbiology Spectrum |
| primary_location.source.host_organization | https://openalex.org/P4310320263 |
| primary_location.source.host_organization_name | American Society for Microbiology |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320263 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Microbiology Spectrum |
| primary_location.landing_page_url | https://doi.org/10.1128/spectrum.02347-24 |
| publication_date | 2025-03-05 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2806115289, https://openalex.org/W2076176349, https://openalex.org/W2087148357, https://openalex.org/W2111899369, https://openalex.org/W2144652247, https://openalex.org/W2115617484, https://openalex.org/W3214706838, https://openalex.org/W2026145380, https://openalex.org/W2524429440, https://openalex.org/W2522054472, https://openalex.org/W2099610218, https://openalex.org/W2237797200, https://openalex.org/W1986689363, https://openalex.org/W2946416264, https://openalex.org/W2805015236, https://openalex.org/W2575503691, https://openalex.org/W2143475407, https://openalex.org/W2580172796, https://openalex.org/W2781794792, https://openalex.org/W2580190897, https://openalex.org/W2168169019, https://openalex.org/W3002781209, https://openalex.org/W2124219221, https://openalex.org/W2120055283, https://openalex.org/W179303711, https://openalex.org/W2084037207, https://openalex.org/W2039667276, https://openalex.org/W2135433503, https://openalex.org/W2065840126, https://openalex.org/W2059408934, https://openalex.org/W2131423211, https://openalex.org/W2903240692, https://openalex.org/W3036297724, https://openalex.org/W2094863064, https://openalex.org/W2989621866, https://openalex.org/W3091285461, https://openalex.org/W2973725957, https://openalex.org/W2954873408, https://openalex.org/W2053800551, https://openalex.org/W2147881941, https://openalex.org/W2074901911, https://openalex.org/W1970098146, https://openalex.org/W2991810018, https://openalex.org/W2049232681, https://openalex.org/W1976307282, https://openalex.org/W2135342726, https://openalex.org/W2076167337, https://openalex.org/W3130927792, https://openalex.org/W3139952408, https://openalex.org/W4210475148, https://openalex.org/W2571998636, https://openalex.org/W1971663674, https://openalex.org/W2577626296, https://openalex.org/W2564952670, https://openalex.org/W1892689796, https://openalex.org/W2052897173, https://openalex.org/W2677981690 |
| referenced_works_count | 57 |
| abstract_inverted_index.a | 164, 284 |
| abstract_inverted_index.In | 234 |
| abstract_inverted_index.an | 6, 13, 180, 186, 280 |
| abstract_inverted_index.as | 98 |
| abstract_inverted_index.by | 30, 71 |
| abstract_inverted_index.in | 18, 48, 146, 158, 249 |
| abstract_inverted_index.is | 5, 179, 223, 279 |
| abstract_inverted_index.of | 57, 120, 195, 217, 247, 261, 287, 290 |
| abstract_inverted_index.to | 40, 46, 80, 169, 204, 208, 230, 243, 256 |
| abstract_inverted_index.DNA | 21, 211, 251 |
| abstract_inverted_index.MDV | 58, 156, 168, 229, 237 |
| abstract_inverted_index.Rel | 117, 258 |
| abstract_inverted_index.The | 20, 88 |
| abstract_inverted_index.US3 | 61, 76, 89, 101, 113, 138, 238, 294 |
| abstract_inverted_index.and | 15, 66, 73, 125, 132, 142, 150, 193, 266, 273 |
| abstract_inverted_index.did | 104 |
| abstract_inverted_index.for | 94, 167, 214, 228 |
| abstract_inverted_index.its | 95 |
| abstract_inverted_index.not | 105 |
| abstract_inverted_index.p65 | 124, 265 |
| abstract_inverted_index.the | 42, 82, 99, 116, 121, 191, 210, 215, 218, 226, 245, 250, 257, 262, 288 |
| abstract_inverted_index.via | 254 |
| abstract_inverted_index.was | 77, 92, 241 |
| abstract_inverted_index.κB | 85 |
| abstract_inverted_index.DNA. | 75 |
| abstract_inverted_index.IL-6 | 143 |
| abstract_inverted_index.This | 51, 278 |
| abstract_inverted_index.been | 202 |
| abstract_inverted_index.beta | 63 |
| abstract_inverted_index.have | 36, 201 |
| abstract_inverted_index.host | 43, 49, 171 |
| abstract_inverted_index.many | 31 |
| abstract_inverted_index.p50, | 126, 267 |
| abstract_inverted_index.that | 54, 112, 184 |
| abstract_inverted_index.this | 232, 235 |
| abstract_inverted_index.with | 10, 115 |
| abstract_inverted_index.(MDV) | 4, 178 |
| abstract_inverted_index.avian | 7, 182, 291 |
| abstract_inverted_index.evade | 41, 170 |
| abstract_inverted_index.found | 53 |
| abstract_inverted_index.human | 199 |
| abstract_inverted_index.known | 224 |
| abstract_inverted_index.lower | 151 |
| abstract_inverted_index.novel | 165 |
| abstract_inverted_index.shown | 79, 203 |
| abstract_inverted_index.study | 52 |
| abstract_inverted_index.their | 134, 275 |
| abstract_inverted_index.these | 129, 161, 270 |
| abstract_inverted_index.viral | 74, 148 |
| abstract_inverted_index.virus | 3, 177 |
| abstract_inverted_index.which | 127, 268 |
| abstract_inverted_index.while | 34 |
| abstract_inverted_index.(IL-6) | 68 |
| abstract_inverted_index.IFN-β | 141 |
| abstract_inverted_index.NF-κB | 107, 122, 248, 263 |
| abstract_inverted_index.better | 285 |
| abstract_inverted_index.causes | 185 |
| abstract_inverted_index.cells. | 50 |
| abstract_inverted_index.during | 155 |
| abstract_inverted_index.evolve | 205 |
| abstract_inverted_index.factor | 84 |
| abstract_inverted_index.health | 192 |
| abstract_inverted_index.immune | 26, 44 |
| abstract_inverted_index.innate | 25, 220 |
| abstract_inverted_index.kinase | 60, 90, 240 |
| abstract_inverted_index.lesion | 153 |
| abstract_inverted_index.little | 222 |
| abstract_inverted_index.mutant | 102 |
| abstract_inverted_index.reveal | 163 |
| abstract_inverted_index.showed | 111 |
| abstract_inverted_index.study, | 236 |
| abstract_inverted_index.toward | 283 |
| abstract_inverted_index.Further | 109 |
| abstract_inverted_index.Whereas | 198 |
| abstract_inverted_index.abolish | 81 |
| abstract_inverted_index.against | 28 |
| abstract_inverted_index.binding | 255 |
| abstract_inverted_index.blocked | 133 |
| abstract_inverted_index.defense | 27 |
| abstract_inverted_index.disease | 2, 17, 176, 189 |
| abstract_inverted_index.domains | 119, 260 |
| abstract_inverted_index.ectopic | 55 |
| abstract_inverted_index.encoded | 293 |
| abstract_inverted_index.evasion | 216 |
| abstract_inverted_index.evolved | 37 |
| abstract_inverted_index.factors | 131, 272 |
| abstract_inverted_index.finding | 282 |
| abstract_inverted_index.further | 78 |
| abstract_inverted_index.induced | 70 |
| abstract_inverted_index.inhibit | 106, 209, 244 |
| abstract_inverted_index.kinase. | 296 |
| abstract_inverted_index.nuclear | 83, 135, 276 |
| abstract_inverted_index.pathway | 23, 253 |
| abstract_inverted_index.poultry | 196 |
| abstract_inverted_index.protein | 59, 239, 295 |
| abstract_inverted_index.reduced | 147 |
| abstract_inverted_index.sensing | 22, 212, 252 |
| abstract_inverted_index.studies | 110 |
| abstract_inverted_index.survive | 47 |
| abstract_inverted_index.various | 206 |
| abstract_inverted_index.viruses | 35 |
| abstract_inverted_index.welfare | 194 |
| abstract_inverted_index.(IFN-β) | 65 |
| abstract_inverted_index.(NF-κB) | 86 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.Finally, | 137 |
| abstract_inverted_index.activity | 91 |
| abstract_inverted_index.disease, | 12 |
| abstract_inverted_index.findings | 162 |
| abstract_inverted_index.homology | 118, 259 |
| abstract_inverted_index.host’s | 219 |
| abstract_inverted_index.mediates | 24 |
| abstract_inverted_index.multiple | 38 |
| abstract_inverted_index.pathway. | 233 |
| abstract_inverted_index.promoted | 140 |
| abstract_inverted_index.regulate | 231 |
| abstract_inverted_index.response | 45 |
| abstract_inverted_index.subunits | 123, 264 |
| abstract_inverted_index.Marek’s | 1, 11, 175 |
| abstract_inverted_index.abolished | 274 |
| abstract_inverted_index.affecting | 190 |
| abstract_inverted_index.antiviral | 172 |
| abstract_inverted_index.chickens. | 19, 159 |
| abstract_inverted_index.function, | 97 |
| abstract_inverted_index.functions | 289 |
| abstract_inverted_index.immunity, | 221 |
| abstract_inverted_index.immunity. | 173 |
| abstract_inverted_index.important | 188, 281 |
| abstract_inverted_index.incidence | 154 |
| abstract_inverted_index.infection | 29, 157 |
| abstract_inverted_index.inhibited | 62 |
| abstract_inverted_index.mechanism | 166, 227 |
| abstract_inverted_index.oncogenic | 181 |
| abstract_inverted_index.regarding | 225 |
| abstract_inverted_index.resulting | 145 |
| abstract_inverted_index.signaling | 213 |
| abstract_inverted_index.(US3K220A) | 103 |
| abstract_inverted_index.IMPORTANCE | 174 |
| abstract_inverted_index.activation | 246 |
| abstract_inverted_index.associated | 9 |
| abstract_inverted_index.deficiency | 139 |
| abstract_inverted_index.expression | 56 |
| abstract_inverted_index.inhibitory | 96 |
| abstract_inverted_index.interacted | 114 |
| abstract_inverted_index.interferon | 64 |
| abstract_inverted_index.pathogens, | 33 |
| abstract_inverted_index.production | 69 |
| abstract_inverted_index.strategies | 39, 207 |
| abstract_inverted_index.worldwide. | 197 |
| abstract_inverted_index.Altogether, | 160 |
| abstract_inverted_index.activation. | 87, 108 |
| abstract_inverted_index.kinase-dead | 100 |
| abstract_inverted_index.production, | 144 |
| abstract_inverted_index.replication | 149 |
| abstract_inverted_index.MDV-specific | 152 |
| abstract_inverted_index.demonstrated | 242 |
| abstract_inverted_index.economically | 187 |
| abstract_inverted_index.herpesviruses | 200 |
| abstract_inverted_index.indispensable | 93 |
| abstract_inverted_index.interleukin-6 | 67 |
| abstract_inverted_index.transcription | 130, 271 |
| abstract_inverted_index.understanding | 286 |
| abstract_inverted_index.DNA-containing | 32 |
| abstract_inverted_index.phosphorylated | 128 |
| abstract_inverted_index.translocation. | 136, 277 |
| abstract_inverted_index.alphaherpesvirus | 8, 183 |
| abstract_inverted_index.immunosuppressive | 14 |
| abstract_inverted_index.alphaherpesviruses | 292 |
| abstract_inverted_index.hyperphosphorylated | 269 |
| abstract_inverted_index.lymphoproliferative | 16 |
| abstract_inverted_index.interferon-stimulatory | 72 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 13 |
| citation_normalized_percentile.value | 0.10009658 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |