Marginating transitional B cells modulate neutrophils in the lung during inflammation and pneumonia Article Swipe
John Podstawka
,
Sarthak Sinha
,
Carlos Hiroji Hiroki
,
Nicole Sarden
,
Elise Granton
,
Elodie Labit
,
Jung Hwan Kim
,
Graciela Andonegui
,
Yuefei Lou
,
Brendan D. Snarr
,
Donald C. Sheppard
,
Nicole L. Rosin
,
Jeff Biernaskie
,
Bryan G. Yipp
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1084/jem.20210409
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1084/jem.20210409
Pulmonary innate immunity is required for host defense; however, excessive neutrophil inflammation can cause life-threatening acute lung injury. B lymphocytes can be regulatory, yet little is known about peripheral transitional IgM+ B cells in terms of regulatory properties. Using single-cell RNA sequencing, we discovered eight IgM+ B cell subsets with unique gene regulatory networks in the lung circulation dominated by transitional type 1 B and type 2 B (T2B) cells. Lung intravital confocal microscopy revealed that T2B cells marginate in the pulmonary capillaries via CD49e and require CXCL13 and CXCR5. During lung inflammation, marginated T2B cells dampened excessive neutrophil vascular inflammation via the specialized proresolving molecule lipoxin A4 (LXA4). Exogenous CXCL13 dampened excessive neutrophilic inflammation by increasing marginated B cells, and LXA4 recapitulated neutrophil regulation in B cell–deficient mice during inflammation and fungal pneumonia. Thus, the lung microvasculature is enriched in multiple IgM+ B cell subsets with marginating capillary T2B cells that dampen neutrophil responses.
Related Topics
Concepts
Inflammation
Lung
CXCL13
Immunology
Pneumonia
Biology
Medicine
Chemokine
Internal medicine
Chemokine receptor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1084/jem.20210409
- OA Status
- green
- Cited By
- 28
- References
- 86
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3184275451Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1084/jem.20210409Digital Object Identifier
- Title
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Marginating transitional B cells modulate neutrophils in the lung during inflammation and pneumoniaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-07-27Full publication date if available
- Authors
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John Podstawka, Sarthak Sinha, Carlos Hiroji Hiroki, Nicole Sarden, Elise Granton, Elodie Labit, Jung Hwan Kim, Graciela Andonegui, Yuefei Lou, Brendan D. Snarr, Donald C. Sheppard, Nicole L. Rosin, Jeff Biernaskie, Bryan G. YippList of authors in order
- Landing page
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https://doi.org/10.1084/jem.20210409Publisher landing page
- Open access
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/8318832Direct OA link when available
- Concepts
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Inflammation, Lung, CXCL13, Immunology, Pneumonia, Biology, Medicine, Chemokine, Internal medicine, Chemokine receptorTop concepts (fields/topics) attached by OpenAlex
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28Total citation count in OpenAlex
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2025: 9, 2024: 5, 2023: 5, 2022: 6, 2021: 3Per-year citation counts (last 5 years)
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86Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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