Marsdeniae tenacissima extract-induced growth inhibition and apoptosis in hepatoma carcinoma cells is mediated through the p53/nuclear factor-κB signaling pathway Article Swipe
Zhen Wang
,
You‐Min Ying
,
Kaiqiang Li
,
Yu Zhang
,
Bingyu Chen
,
Jingjing Zeng
,
Xujun He
,
Mengmeng Jiang
,
Ben-Yang Chen
,
Ying Wang
,
Xiaodong Xu
,
Ke Hao
,
Meng-hua Zhu
,
Wei Zhang
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.3892/etm.2017.4833
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.3892/etm.2017.4833
An extract from a traditional Chinese herb, Marsdeniae tenacissima (trade name, Xiao-Ai-Ping) has been approved for use on the Chinese market as a cancer chemotherapeutic agent for decades. Previous studies have demonstrated the cytostatic and pro-apoptotic effects of M. tenacissima extract (MTE) in multiple cancer cells. However, the contributions of MTE to the proliferation and apoptosis of hepatoma carcinoma cells and the underlying mechanisms remain unclear. In the present study, Bel-7402 cells were incubated with increasing concentrations of MTE ranging from 0-320 µl/ml to explore the effects and potential mechanisms of MTE on the proliferation and apoptosis of Bel-7402 cells. 3-(4,5-dimethylthiazol-2-yl)-5(3-carboxymethoxyphenyl)-2-(4-sulfopheny)-2H-tetrazolium, inner salt and propidium iodide (PI)-stained flow cytometry assays demonstrated that MTE significantly suppressed the proliferation of Bel-7402 cells in a dose-dependent manner by arresting the cell cycle at S phase (P<0.05). Annexin V-fluorescein isothiocyanate PI-stained flow cytometry confirmed the significantly pro-apoptotic effect of MTE at both 160 and 240 µl/ml (P<0.001). Reverse transcription-quantitative polymerase chain reaction and western blot analysis demonstrated that MTE (both 160 and 240 µl/ml) induced a significant downregulation of B-cell lymphoma (Bcl)-2 (P<0.01), upregulation of Bcl-2-associated X protein (P<0.01) and activation of caspase-3 (P<0.05). Furthermore, a significant downregulation of murine double minute-2 (MDM2) (P<0.001) and activation of p53 (P<0.001) in Bel-7402 cells following treatment with 160 or 240 µl/ml MTE was observed, accompanied by the inhibition of the nuclear factor (NF)-κB pathway (P<0.001). These results suggested that MTE inhibited growth and exhibited pro-apoptotic effects in Bel-7402 cells, which was mediated by downregulation of the MDM2-induced p53-dependent mitochondrial apoptosis pathway and blocking the NF-κB pathway. Overall, these data serve as preliminary identification of the significant roles of MTE in hepatic carcinoma cells, and suggest that MTE may be a promising candidate for hepatocellular carcinoma therapy.
Related Topics
Concepts
Apoptosis
Oncogene
Cell cycle
Cancer research
Signal transduction
Molecular medicine
Biology
A431 cells
Cell biology
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/etm.2017.4833
- http://www.spandidos-publications.com/10.3892/etm.2017.4833/download
- OA Status
- diamond
- Cited By
- 3
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2737005770
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2737005770Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3892/etm.2017.4833Digital Object Identifier
- Title
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Marsdeniae tenacissima extract-induced growth inhibition and apoptosis in hepatoma carcinoma cells is mediated through the p53/nuclear factor-κB signaling pathwayWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-07-25Full publication date if available
- Authors
-
Zhen Wang, You‐Min Ying, Kaiqiang Li, Yu Zhang, Bingyu Chen, Jingjing Zeng, Xujun He, Mengmeng Jiang, Ben-Yang Chen, Ying Wang, Xiaodong Xu, Ke Hao, Meng-hua Zhu, Wei ZhangList of authors in order
- Landing page
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https://doi.org/10.3892/etm.2017.4833Publisher landing page
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https://www.spandidos-publications.com/10.3892/etm.2017.4833/downloadDirect link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://www.spandidos-publications.com/10.3892/etm.2017.4833/downloadDirect OA link when available
- Concepts
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Apoptosis, Oncogene, Cell cycle, Cancer research, Signal transduction, Molecular medicine, Biology, A431 cells, Cell biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
- Citations by year (recent)
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2021: 1, 2020: 1, 2018: 1Per-year citation counts (last 5 years)
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42Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.have | 30 |
| abstract_inverted_index.salt | 102 |
| abstract_inverted_index.that | 111, 163, 232, 279 |
| abstract_inverted_index.were | 72 |
| abstract_inverted_index.with | 74, 210 |
| abstract_inverted_index.(MTE) | 41 |
| abstract_inverted_index.(both | 165 |
| abstract_inverted_index.0-320 | 81 |
| abstract_inverted_index.<i>M. | 38 |
| abstract_inverted_index.These | 229 |
| abstract_inverted_index.agent | 25 |
| abstract_inverted_index.cells | 59, 71, 119, 207 |
| abstract_inverted_index.chain | 156 |
| abstract_inverted_index.cycle | 128 |
| abstract_inverted_index.herb, | 6 |
| abstract_inverted_index.inner | 101 |
| abstract_inverted_index.name, | 10 |
| abstract_inverted_index.phase | 131 |
| abstract_inverted_index.roles | 270 |
| abstract_inverted_index.serve | 263 |
| abstract_inverted_index.these | 261 |
| abstract_inverted_index.which | 243 |
| abstract_inverted_index.(MDM2) | 198 |
| abstract_inverted_index.(trade | 9 |
| abstract_inverted_index.B-cell | 175 |
| abstract_inverted_index.NF-κB | 258 |
| abstract_inverted_index.assays | 109 |
| abstract_inverted_index.cancer | 23, 44 |
| abstract_inverted_index.cells, | 242, 276 |
| abstract_inverted_index.cells. | 45, 99 |
| abstract_inverted_index.double | 196 |
| abstract_inverted_index.effect | 143 |
| abstract_inverted_index.factor | 225 |
| abstract_inverted_index.growth | 235 |
| abstract_inverted_index.iodide | 105 |
| abstract_inverted_index.manner | 123 |
| abstract_inverted_index.market | 20 |
| abstract_inverted_index.murine | 195 |
| abstract_inverted_index.remain | 64 |
| abstract_inverted_index.study, | 69 |
| abstract_inverted_index.µl/ml | 82, 151, 214 |
| abstract_inverted_index.(Bcl)-2 | 177 |
| abstract_inverted_index.Annexin | 133 |
| abstract_inverted_index.Chinese | 5, 19 |
| abstract_inverted_index.Reverse | 153 |
| abstract_inverted_index.effects | 36, 86, 239 |
| abstract_inverted_index.explore | 84 |
| abstract_inverted_index.extract | 1, 40 |
| abstract_inverted_index.hepatic | 274 |
| abstract_inverted_index.induced | 170 |
| abstract_inverted_index.nuclear | 224 |
| abstract_inverted_index.pathway | 227, 254 |
| abstract_inverted_index.present | 68 |
| abstract_inverted_index.protein | 183 |
| abstract_inverted_index.ranging | 79 |
| abstract_inverted_index.results | 230 |
| abstract_inverted_index.studies | 29 |
| abstract_inverted_index.suggest | 278 |
| abstract_inverted_index.western | 159 |
| abstract_inverted_index.µl/ml) | 169 |
| abstract_inverted_index.(NF)-κB | 226 |
| abstract_inverted_index.(P<0.01) | 184 |
| abstract_inverted_index.Bel-7402 | 70, 98, 118, 206, 241 |
| abstract_inverted_index.However, | 46 |
| abstract_inverted_index.Overall, | 260 |
| abstract_inverted_index.Previous | 28 |
| abstract_inverted_index.analysis | 161 |
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| abstract_inverted_index.blocking | 256 |
| abstract_inverted_index.decades. | 27 |
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| abstract_inverted_index.lymphoma | 176 |
| abstract_inverted_index.mediated | 245 |
| abstract_inverted_index.minute-2 | 197 |
| abstract_inverted_index.multiple | 43 |
| abstract_inverted_index.pathway. | 259 |
| abstract_inverted_index.reaction | 157 |
| abstract_inverted_index.therapy. | 289 |
| abstract_inverted_index.unclear. | 65 |
| abstract_inverted_index.(P<0.001) | 199, 204 |
| abstract_inverted_index.(P<0.01), | 178 |
| abstract_inverted_index.(P<0.05). | 132, 189 |
| abstract_inverted_index.apoptosis | 55, 96, 253 |
| abstract_inverted_index.arresting | 125 |
| abstract_inverted_index.candidate | 285 |
| abstract_inverted_index.carcinoma | 58, 275, 288 |
| abstract_inverted_index.caspase-3 | 188 |
| abstract_inverted_index.confirmed | 139 |
| abstract_inverted_index.cytometry | 108, 138 |
| abstract_inverted_index.exhibited | 237 |
| abstract_inverted_index.following | 208 |
| abstract_inverted_index.incubated | 73 |
| abstract_inverted_index.inhibited | 234 |
| abstract_inverted_index.observed, | 217 |
| abstract_inverted_index.potential | 88 |
| abstract_inverted_index.promising | 284 |
| abstract_inverted_index.propidium | 104 |
| abstract_inverted_index.suggested | 231 |
| abstract_inverted_index.treatment | 209 |
| abstract_inverted_index.(P<0.001). | 152, 228 |
| abstract_inverted_index.PI-stained | 136 |
| abstract_inverted_index.activation | 186, 201 |
| abstract_inverted_index.cytostatic | 33 |
| abstract_inverted_index.increasing | 75 |
| abstract_inverted_index.inhibition | 221 |
| abstract_inverted_index.mechanisms | 63, 89 |
| abstract_inverted_index.polymerase | 155 |
| abstract_inverted_index.suppressed | 114 |
| abstract_inverted_index.underlying | 62 |
| abstract_inverted_index.accompanied | 218 |
| abstract_inverted_index.preliminary | 265 |
| abstract_inverted_index.significant | 172, 192, 269 |
| abstract_inverted_index.traditional | 4 |
| abstract_inverted_index.(PI)-stained | 106 |
| abstract_inverted_index.Furthermore, | 190 |
| abstract_inverted_index.MDM2-induced | 250 |
| abstract_inverted_index.demonstrated | 31, 110, 162 |
| abstract_inverted_index.upregulation | 179 |
| abstract_inverted_index.<i>Marsdeniae | 7 |
| abstract_inverted_index.V-fluorescein | 134 |
| abstract_inverted_index.Xiao-Ai-Ping) | 11 |
| abstract_inverted_index.contributions | 48 |
| abstract_inverted_index.mitochondrial | 252 |
| abstract_inverted_index.p53-dependent | 251 |
| abstract_inverted_index.pro-apoptotic | 35, 142, 238 |
| abstract_inverted_index.proliferation | 53, 94, 116 |
| abstract_inverted_index.significantly | 113, 141 |
| abstract_inverted_index.concentrations | 76 |
| abstract_inverted_index.dose-dependent | 122 |
| abstract_inverted_index.downregulation | 173, 193, 247 |
| abstract_inverted_index.hepatocellular | 287 |
| abstract_inverted_index.identification | 266 |
| abstract_inverted_index.isothiocyanate | 135 |
| abstract_inverted_index.tenacissima</i> | 8, 39 |
| abstract_inverted_index.Bcl-2-associated | 181 |
| abstract_inverted_index.chemotherapeutic | 24 |
| abstract_inverted_index.transcription-quantitative | 154 |
| abstract_inverted_index.3-(4,5-dimethylthiazol-2-yl)-5(3-carboxymethoxyphenyl)-2-(4-sulfopheny)-2H-tetrazolium, | 100 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 14 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6000000238418579 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.50315041 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |