MASH Native: a unified solution for native top-down proteomics data processing Article Swipe
Eli J. Larson
,
Melissa R. Pergande
,
Michelle E. Moss
,
Kalina J. Rossler
,
Rephael Wenger
,
Boris Krichel
,
Harini Josyer
,
Jake A. Melby
,
David S. Roberts
,
Kyndalanne Pike
,
Zhuoxin Shi
,
Hsin‐Ju Chan
,
Bridget Knight
,
Holden T. Rogers
,
Kyle A. Brown
,
Irene M. Ong
,
Kyowon Jeong
,
Michael T. Marty
,
Sean J. McIlwain
,
Ying Ge
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/bioinformatics/btad359
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/bioinformatics/btad359
Motivation Native top-down proteomics (nTDP) integrates native mass spectrometry (nMS) with top-down proteomics (TDP) to provide comprehensive analysis of protein complexes together with proteoform identification and characterization. Despite significant advances in nMS and TDP software developments, a unified and user-friendly software package for analysis of nTDP data remains lacking. Results We have developed MASH Native to provide a unified solution for nTDP to process complex datasets with database searching capabilities in a user-friendly interface. MASH Native supports various data formats and incorporates multiple options for deconvolution, database searching, and spectral summing to provide a “one-stop shop” for characterizing both native protein complexes and proteoforms. Availability and implementation The MASH Native app, video tutorials, written tutorials, and additional documentation are freely available for download at https://labs.wisc.edu/gelab/MASH_Explorer/MASHSoftware.php. All data files shown in user tutorials are included with the MASH Native software in the download .zip file.
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Metadata
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- Language
- en
- Landing Page
- https://doi.org/10.1093/bioinformatics/btad359
- https://academic.oup.com/bioinformatics/article-pdf/39/6/btad359/50664577/btad359.pdf
- OA Status
- gold
- Cited By
- 30
- References
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- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4380146570
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4380146570Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/bioinformatics/btad359Digital Object Identifier
- Title
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MASH Native: a unified solution for native top-down proteomics data processingWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-06-01Full publication date if available
- Authors
-
Eli J. Larson, Melissa R. Pergande, Michelle E. Moss, Kalina J. Rossler, Rephael Wenger, Boris Krichel, Harini Josyer, Jake A. Melby, David S. Roberts, Kyndalanne Pike, Zhuoxin Shi, Hsin‐Ju Chan, Bridget Knight, Holden T. Rogers, Kyle A. Brown, Irene M. Ong, Kyowon Jeong, Michael T. Marty, Sean J. McIlwain, Ying GeList of authors in order
- Landing page
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https://doi.org/10.1093/bioinformatics/btad359Publisher landing page
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https://academic.oup.com/bioinformatics/article-pdf/39/6/btad359/50664577/btad359.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://academic.oup.com/bioinformatics/article-pdf/39/6/btad359/50664577/btad359.pdfDirect OA link when available
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Computer science, Software, Documentation, Interface (matter), Download, Source code, User Friendly, Database, World Wide Web, Information retrieval, Programming language, Operating system, Maximum bubble pressure method, BubbleTop concepts (fields/topics) attached by OpenAlex
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30Total citation count in OpenAlex
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2025: 15, 2024: 8, 2023: 7Per-year citation counts (last 5 years)
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39Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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