Mass drug administration for endemic scabies: a systematic review Article Swipe
YOU?
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· 2021
· Open Access
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· DOI: https://doi.org/10.1186/s40794-021-00143-5
Background Scabies is an extremely fastidious infestation caused by the Sarcoptes scabiei mite. It causes a persistent itch that can disrupt a person’s mental health, sleep, and overall quality of life. In endemic areas, treatment by targeting symptomatic individuals and their contacts is often unsuccessful due to an asymptomatic period and high rates of re-infection. To overcome this, Mass Drug Administration (MDA) is often used to treat the whole community, irrespective of whether individuals presently have scabies. This review summarises the evidence for the effectiveness of MDA in treating scabies. Methods An exhaustive literature review was conducted on MEDLINE, EMBASE, Web of Science and Scopus. All peer-reviewed articles published in English January 1990 to March 2020 were eligible and only if the studies were primary and interventional. Furthermore, the intervention had to be a pharmacological MDA method involving human subjects. Results TWELVE articles that qualified for inclusion were identified. MDA for scabies significantly reduced its prevalence in communities at follow up. Some of the drivers of success were communities with low levels of migration, an uptake of MDA of > 85%, the use of oral Ivermectin therapy, the treatment of children and pregnant women within the treated population, and repeated treatment for participants diagnosed with scabies at baseline. Conclusions The average absolute reduction in prevalence of scabies was 22.0% and the relative reduction average was 73.4%. These results suggest MDA is effective in treating scabies in the endemic community. Further evidence is needed surrounding MDA use in urban areas with increased levels of migration. Importantly, MDA should not substitute the tackling of socioeconomic factors which contribute to endemic disease such as good sanitation and hygiene.
Related Topics
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1186/s40794-021-00143-5
- https://tdtmvjournal.biomedcentral.com/counter/pdf/10.1186/s40794-021-00143-5
- OA Status
- gold
- Cited By
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- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W3173694019
Raw OpenAlex JSON
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https://openalex.org/W3173694019Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s40794-021-00143-5Digital Object Identifier
- Title
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Mass drug administration for endemic scabies: a systematic reviewWork title
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
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2021-07-01Full publication date if available
- Authors
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Giulia Rinaldi, Kholoud PorterList of authors in order
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https://doi.org/10.1186/s40794-021-00143-5Publisher landing page
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https://tdtmvjournal.biomedcentral.com/counter/pdf/10.1186/s40794-021-00143-5Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://tdtmvjournal.biomedcentral.com/counter/pdf/10.1186/s40794-021-00143-5Direct OA link when available
- Concepts
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Ivermectin, Scabies, Medicine, Sarcoptes scabiei, Population, Asymptomatic, Mite, Mass drug administration, Dermatology, Environmental health, Internal medicine, Veterinary medicine, Biology, EcologyTop concepts (fields/topics) attached by OpenAlex
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2025: 5, 2024: 4, 2023: 5, 2022: 4Per-year citation counts (last 5 years)
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61Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2160055163, https://openalex.org/W2674126249, https://openalex.org/W2052636849, https://openalex.org/W1881608356, https://openalex.org/W2093919135, https://openalex.org/W2904685242, https://openalex.org/W2122231026, https://openalex.org/W1899735501, https://openalex.org/W2490296254, https://openalex.org/W1550895048, https://openalex.org/W2759013423, https://openalex.org/W2040855863, https://openalex.org/W1964081449, https://openalex.org/W2100673908, https://openalex.org/W4211083946, https://openalex.org/W2099269010, https://openalex.org/W2897858596, https://openalex.org/W2903798425, https://openalex.org/W2895040344, https://openalex.org/W2531269403, https://openalex.org/W2870426619, https://openalex.org/W2928276993, https://openalex.org/W2098013497, https://openalex.org/W2162950025, https://openalex.org/W2317702186, https://openalex.org/W2052410767, https://openalex.org/W2886427597, https://openalex.org/W1961648385, https://openalex.org/W1969738950, https://openalex.org/W2084637194, https://openalex.org/W2150173657, https://openalex.org/W1549510969, https://openalex.org/W2563702484, https://openalex.org/W2803735244, https://openalex.org/W4300808044, https://openalex.org/W2112570386, https://openalex.org/W2765212307, https://openalex.org/W2795741587, https://openalex.org/W2998032101, https://openalex.org/W2893593751, https://openalex.org/W2617141899, https://openalex.org/W2616280353, https://openalex.org/W2023125550, https://openalex.org/W2962597233, https://openalex.org/W2462776788, https://openalex.org/W2888499872, https://openalex.org/W2045214365, https://openalex.org/W2002939602, https://openalex.org/W2973786697, https://openalex.org/W2150554344, https://openalex.org/W2158606409, https://openalex.org/W1966302133, https://openalex.org/W2165091615, https://openalex.org/W2530929148, https://openalex.org/W2973678928, https://openalex.org/W2953998387, https://openalex.org/W2187394260, https://openalex.org/W2133348795, https://openalex.org/W2978160280, https://openalex.org/W4211250544, https://openalex.org/W2946857541 |
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