Mass screening of asymptomatic persons for SARS-CoV-2 using saliva Article Swipe
Isao Yokota
,
Peter Y. Shane
,
Kazufumi Okada
,
Yoko Unoki
,
Yichi Yang
,
Tasuku Inao
,
Kentaro Sakamaki
,
Sumio Iwasaki
,
Kasumi Hayasaka
,
Junichi Sugita
,
Mutsumi Nishida
,
Shinichi Fujisawa
,
Takanori Teshima
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.08.13.20174078
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.08.13.20174078
Background COVID-19 has rapidly evolved to become a global pandemic due largely to the transmission of its causative virus through asymptomatic carriers. Detection of SARS-CoV-2 in asymptomatic people is an urgent priority for the prevention and containment of disease outbreaks in communities. However, few data are available in asymptomatic persons regarding the accuracy of PCR testing. Additionally, although self-collected saliva has significant logistical advantages in mass screening, its utility as an alternative specimen in asymptomatic persons is yet to be determined. Methods We conducted a mass-screening study to compare the utility of nucleic acid amplification, such as reverse transcriptase polymerase chain reaction (RT-PCR) testing, using NPS and saliva samples from each individual in two cohorts of asymptomatic persons: the contact tracing cohort and the airport quarantine cohort. Results In this mass-screening study including 1,924 individuals, the sensitivity of nucleic acid amplification testing with nasopharyngeal and saliva specimens were 86% (90%CI:77-93%) and 92% (90%CI:83-97%), respectively, with specificities greater than 99.9%. The true concordance probability between the nasopharyngeal and saliva tests was estimated at 0.998 (90%CI:0.996-0.999) on the estimated airport prevalence, 0.3%. In positive individuals, viral load was highly correlated between NPS and saliva. Conclusion Both nasopharyngeal and saliva specimens had high sensitivity and specificity. Self-collected saliva is a valuable specimen to detect SARS-CoV-2 in mass screening of asymptomatic persons.
Related Topics
Concepts
Saliva
Asymptomatic
Medicine
Contact tracing
Concordance
Outbreak
Cohort
Transmission (telecommunications)
Polymerase chain reaction
Cohort study
Virology
Coronavirus disease 2019 (COVID-19)
Internal medicine
Disease
Biology
Genetics
Infectious disease (medical specialty)
Gene
Engineering
Electrical engineering
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.08.13.20174078
- https://www.medrxiv.org/content/medrxiv/early/2020/08/15/2020.08.13.20174078.full.pdf
- OA Status
- green
- Cited By
- 45
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3049370894
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3049370894Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.08.13.20174078Digital Object Identifier
- Title
-
Mass screening of asymptomatic persons for SARS-CoV-2 using salivaWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-08-14Full publication date if available
- Authors
-
Isao Yokota, Peter Y. Shane, Kazufumi Okada, Yoko Unoki, Yichi Yang, Tasuku Inao, Kentaro Sakamaki, Sumio Iwasaki, Kasumi Hayasaka, Junichi Sugita, Mutsumi Nishida, Shinichi Fujisawa, Takanori TeshimaList of authors in order
- Landing page
-
https://doi.org/10.1101/2020.08.13.20174078Publisher landing page
- PDF URL
-
https://www.medrxiv.org/content/medrxiv/early/2020/08/15/2020.08.13.20174078.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.medrxiv.org/content/medrxiv/early/2020/08/15/2020.08.13.20174078.full.pdfDirect OA link when available
- Concepts
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Saliva, Asymptomatic, Medicine, Contact tracing, Concordance, Outbreak, Cohort, Transmission (telecommunications), Polymerase chain reaction, Cohort study, Virology, Coronavirus disease 2019 (COVID-19), Internal medicine, Disease, Biology, Genetics, Infectious disease (medical specialty), Gene, Engineering, Electrical engineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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45Total citation count in OpenAlex
- Citations by year (recent)
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2022: 3, 2021: 36, 2020: 6Per-year citation counts (last 5 years)
- References (count)
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32Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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