Massive Multifocal Familial GIST: A Case Report Article Swipe
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.31487/j.scr.2021.09.14
Gastrointestinal stromal tumors (GIST) are uncommon mesenchymal neoplasms of the gastrointestinal tract. The majority of GISTs are the result of sporadic mutations, most commonly of the KIT proto-oncogene. Germline mutations account for 5% of GISTs and result in rare familial syndromes. We present a 66-year-old male with a family history of GIST who presented with mild abdominal pain and was found to have a massive, multifocal GIST. The main tumor was resected via laparotomy and the weight was found over 2 kg. He was commenced on adjuvant therapy with imatinib and will be closely monitored. Familial GISTs tend to be larger, multifocal and diagnosed at a younger age. Familial GISTs are extremely rare conditions. There is little to no evidence on the long-term outcomes of treatment on which to base management decisions.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.31487/j.scr.2021.09.14
- https://www.sciencerepository.org/articles/massive-multifocal-familial_SCR-2021-9-114.pdf
- OA Status
- diamond
- References
- 9
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3216093791
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3216093791Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.31487/j.scr.2021.09.14Digital Object Identifier
- Title
-
Massive Multifocal Familial GIST: A Case ReportWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-24Full publication date if available
- Authors
-
Steven J. Craig, Samuel R Thomson, Su Mae Ang, Steven J. CraigList of authors in order
- Landing page
-
https://doi.org/10.31487/j.scr.2021.09.14Publisher landing page
- PDF URL
-
https://www.sciencerepository.org/articles/massive-multifocal-familial_SCR-2021-9-114.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://www.sciencerepository.org/articles/massive-multifocal-familial_SCR-2021-9-114.pdfDirect OA link when available
- Concepts
-
GiST, Medicine, Gastrointestinal tract, Stromal tumor, Imatinib, Laparotomy, Abdominal pain, Germline mutation, Internal medicine, Surgery, Stromal cell, Mutation, Biology, Genetics, Myeloid leukemia, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
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9Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| publication_year | 2021 |
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