MATCAP1 preferentially binds an expanded tubulin conformation to generate detyrosinated and ΔC2 α-tubulin Article Swipe
Yue Yang
,
Takashi Hotta
,
Ryoma Ohi
,
Kristen J. Verhey
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.14.670257
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.14.670257
Microtubules are cytoskeletal filaments with critical roles in cell division, cell motility, intracellular trafficking, and cilium function. In cells, subsets of microtubules are selectively marked by posttranslational modifications (PTMs), which control the ability of microtubule-associated proteins (MAPs) and molecular motors to engage microtubules. Detyrosination (ΔY) and ΔC2 are PTMs of α-tubulin, wherein one or two residues, respectively, are enzymatically removed from the C-terminus of the protein. How specific patterns of PTMs are generated in cells is not understood. Here, we use in vitro reconstitution assays to investigate the microtubule binding behavior of metallopeptidase MATCAP1 and the mechanism by which it generates ΔY and ΔC2 modifications of α-tubulin. We demonstrate that MATCAP1 preferentially binds to microtubules composed of tubulin subunits in an expanded conformation, which can be induced by preventing β-tubulin GTP hydrolysis, Taxol treatment, or kinesin-1 stepping. MATCAP1 binds to expanded microtubule lattices with long dwell time and sequentially removes the terminal tyrosine residue to generate ΔY-microtubules and the penultimate glutamate residue to generate ΔC2-microtubules. Thus, the lattice conformation of microtubules is a key factor that gates the binding and activity of MATCAP1.
Related Topics
Concepts
Microtubule
Tubulin
Cell biology
Microtubule nucleation
Tyrosine
Microtubule-associated protein
Cytoskeleton
Biology
Chemistry
Biophysics
Biochemistry
Cell
Centrosome
Cell cycle
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.08.14.670257
- https://www.biorxiv.org/content/biorxiv/early/2025/08/18/2025.08.14.670257.full.pdf
- OA Status
- green
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413304749
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413304749Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.08.14.670257Digital Object Identifier
- Title
-
MATCAP1 preferentially binds an expanded tubulin conformation to generate detyrosinated and ΔC2 α-tubulinWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-08-18Full publication date if available
- Authors
-
Yue Yang, Takashi Hotta, Ryoma Ohi, Kristen J. VerheyList of authors in order
- Landing page
-
https://doi.org/10.1101/2025.08.14.670257Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2025/08/18/2025.08.14.670257.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2025/08/18/2025.08.14.670257.full.pdfDirect OA link when available
- Concepts
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Microtubule, Tubulin, Cell biology, Microtubule nucleation, Tyrosine, Microtubule-associated protein, Cytoskeleton, Biology, Chemistry, Biophysics, Biochemistry, Cell, Centrosome, Cell cycleTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| publication_date | 2025-08-18 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2769672674, https://openalex.org/W4399195063, https://openalex.org/W2085331277, https://openalex.org/W2028375545, https://openalex.org/W2806513202, https://openalex.org/W4407185141, https://openalex.org/W4406827923, https://openalex.org/W3165382431, https://openalex.org/W2147332958, https://openalex.org/W4310668133, https://openalex.org/W3194916623, https://openalex.org/W3007078842, https://openalex.org/W1979249841, https://openalex.org/W4393150410, https://openalex.org/W2061382404, https://openalex.org/W4206554895, https://openalex.org/W4225121910, https://openalex.org/W4285411119, https://openalex.org/W6781460993, https://openalex.org/W2948633892, https://openalex.org/W4292636415, https://openalex.org/W2895310363, https://openalex.org/W3045334142, https://openalex.org/W2770502839, https://openalex.org/W2889724929, https://openalex.org/W2791508075, https://openalex.org/W2037066635, https://openalex.org/W3184130251, https://openalex.org/W4281667747, https://openalex.org/W2336853363, https://openalex.org/W2003653198, https://openalex.org/W3038929236, https://openalex.org/W3164809116, https://openalex.org/W4200535840, https://openalex.org/W1965531591, https://openalex.org/W4393899203, https://openalex.org/W2899644340, https://openalex.org/W3211347097, https://openalex.org/W2938998332, https://openalex.org/W2111441789, https://openalex.org/W6668978577, https://openalex.org/W4386769655, https://openalex.org/W2809170986 |
| referenced_works_count | 43 |
| abstract_inverted_index.a | 173 |
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| abstract_inverted_index.an | 121 |
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| abstract_inverted_index.(ΔY) | 45 |
| abstract_inverted_index.Here, | 79 |
| abstract_inverted_index.Taxol | 133 |
| abstract_inverted_index.Thus, | 166 |
| abstract_inverted_index.binds | 113, 139 |
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| abstract_inverted_index.roles | 7 |
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| abstract_inverted_index.motors | 40 |
| abstract_inverted_index.(PTMs), | 29 |
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| abstract_inverted_index.kinesin-1 | 136 |
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| abstract_inverted_index.motility, | 12 |
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| abstract_inverted_index.respectively, | 57 |
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| abstract_inverted_index.posttranslational | 27 |
| abstract_inverted_index.ΔC2-microtubules. | 165 |
| abstract_inverted_index.microtubule-associated | 35 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5075010929 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| corresponding_institution_ids | https://openalex.org/I27837315 |
| citation_normalized_percentile.value | 0.39590665 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |