Material design for oral insulin delivery Article Swipe
Kangfan Ji
,
Yuejun Yao
,
Xinwei Wei
,
Wei Liu
,
Juan Zhang
,
Yun Liu
,
Yang Zhang
,
Jinqiang Wang
,
Zhen Gu
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1007/s44258-023-00006-y
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1007/s44258-023-00006-y
Frequent insulin injections remain the primary method for controlling the blood glucose level of individuals with diabetes mellitus but are associated with low compliance. Accordingly, oral administration has been identified as a highly desirable alternative due to its non-invasive nature. However, the harsh gastrointestinal environment and physical intestinal barriers pose significant challenges to achieving optimal pharmacological bioavailability of insulin. As a result, researchers have developed a range of materials to improve the efficiency of oral insulin delivery over the past few decades. In this review, we summarize the latest advances in material design that aim to enhance insulin protection, permeability, and glucose-responsive release. We also explore the opportunities and challenges of using these materials for oral insulin delivery.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1007/s44258-023-00006-y
- https://link.springer.com/content/pdf/10.1007/s44258-023-00006-y.pdf
- OA Status
- hybrid
- Cited By
- 8
- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W4383743390
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4383743390Canonical identifier for this work in OpenAlex
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https://doi.org/10.1007/s44258-023-00006-yDigital Object Identifier
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Material design for oral insulin deliveryWork title
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reviewOpenAlex work type
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enPrimary language
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2023Year of publication
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2023-07-11Full publication date if available
- Authors
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Kangfan Ji, Yuejun Yao, Xinwei Wei, Wei Liu, Juan Zhang, Yun Liu, Yang Zhang, Jinqiang Wang, Zhen GuList of authors in order
- Landing page
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https://doi.org/10.1007/s44258-023-00006-yPublisher landing page
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https://link.springer.com/content/pdf/10.1007/s44258-023-00006-y.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://link.springer.com/content/pdf/10.1007/s44258-023-00006-y.pdfDirect OA link when available
- Concepts
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Insulin delivery, Insulin, Medicine, Diabetes mellitus, Internal medicine, Endocrinology, Type 1 diabetesTop concepts (fields/topics) attached by OpenAlex
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8Total citation count in OpenAlex
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2025: 2, 2024: 6Per-year citation counts (last 5 years)
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62Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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