Maternal Comorbidity and Adverse Perinatal Outcomes in Female Adolescent and Young Adult Cancer Survivors: a Cohort Study Article Swipe
Milli Desai
,
Beth Zhou
,
Vinit Nalawade
,
Cynthia Gyamfi-Bannerman
,
Nina Veeravalli
,
Henry J. Henk
,
James D. Murphy
,
Brian W. Whitcomb
,
H. Irene Su
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.22541/au.165364022.29840547/v1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.22541/au.165364022.29840547/v1
Objectives: To evaluate risks of preterm birth and severe maternal morbidity (SMM) in female adolescent and young adult cancer survivors; assess maternal comorbidity as a potential mechanism; determine whether associations differ by use of assisted reproductive technology (ART). Design: Retrospective cohort Setting: Privately insured females in the U.S. Sample: Female with live births from 2000 to 2019 within OptumLabs®, a U.S. administrative health claims dataset Methods: Log-binomial regression models estimated relative risks of preterm birth and SMM by cancer status and tested for effect modification. Causal mediation analysis based on a counterfactual approach evaluated the proportions explained by maternal comorbidity. Main Outcome Measures: SMM, preterm birth Results: Among 46,064 cancer survivors, 2,440 singleton births, 214 multiple births, and 2,590 linked newborns occurred after cancer. In singleton births, preterm birth incidence was 14.8% in cancer survivors versus 12.4% in females without cancer (aRR 1.19, 95%CI 1.06-1.34); SMM incidence was 3.9% in cancer survivors versus 2.4% in females without cancer (aRR 1.44, 95%CI 1.13-1.83). Cancer survivors had more maternal comorbidities before and during pregnancy; 26% of the association between cancer and preterm birth and 30% of the association between cancer and SMM was mediated by maternal comorbidities. Associations between cancer and outcomes did not differ between ART and non-ART births. Conclusion: Preterm birth and SMM risks were modestly increased after cancer. Significant proportions of elevated risks may be due to increased comorbidities. Prevention and treatment of comorbidities provides an opportunity to improve perinatal outcomes among cancer survivors.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.22541/au.165364022.29840547/v1
- https://www.authorea.com/doi/pdf/10.22541/au.165364022.29840547
- OA Status
- gold
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281944049
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4281944049Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.22541/au.165364022.29840547/v1Digital Object Identifier
- Title
-
Maternal Comorbidity and Adverse Perinatal Outcomes in Female Adolescent and Young Adult Cancer Survivors: a Cohort StudyWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-05-27Full publication date if available
- Authors
-
Milli Desai, Beth Zhou, Vinit Nalawade, Cynthia Gyamfi-Bannerman, Nina Veeravalli, Henry J. Henk, James D. Murphy, Brian W. Whitcomb, H. Irene SuList of authors in order
- Landing page
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https://doi.org/10.22541/au.165364022.29840547/v1Publisher landing page
- PDF URL
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https://www.authorea.com/doi/pdf/10.22541/au.165364022.29840547Direct link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.authorea.com/doi/pdf/10.22541/au.165364022.29840547Direct OA link when available
- Concepts
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Medicine, Comorbidity, Cancer registry, Cancer, Obstetrics, Incidence (geometry), Pregnancy, Live birth, Cohort study, Relative risk, Premature birth, Gestational age, Internal medicine, Confidence interval, Biology, Genetics, Physics, OpticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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41Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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