Maternal factor PABPN1L is essential for maternal mRNA degradation during maternal-to-zygotic transition Article Swipe
Ying Wang
,
Tianhao Feng
,
Xiaodan Shi
,
Siyu Liu
,
Zerui Wang
,
Xin Zhang
,
Jintao Zhang
,
Shuqin Zhao
,
Junqiang Zhang
,
Xiufeng Ling
,
Mingxi Liu
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.08.20.258830
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.08.20.258830
Infertility affects 10% - 15% of families worldwide. However, the pathogenesis of female infertility caused by abnormal early embryonic development is not clear. We constructed a mouse model (Pabpn1l -/-) simulating the splicing abnormality of human PABPN1L and found that the female was sterile and the male was fertile. The Pabpn1l -/- oocytes can be produced, ovulated and fertilized normally, but cannot develop beyond the 2-cell stage. Using RNA-Seq, we found a large-scale upregulation of RNA in Pabpn1l -/- MII oocytes. Of the 2401 transcripts upregulated in Pabpn1l-/- MII oocytes, 1523 transcripts (63.4%) were also upregulated in Btg4 -/- MII oocytes, while only 53 transcripts (2.2%) were upregulated in Ythdf2 -/- MII oocytes. We documented that transcripts in zygotes derived from Pabpn1l -/- oocytes have a longer poly(A) tail than the control group, a phenomenon similar to that in Btg4-/- mice. Surprisingly, the poly(A) tail of these mRNAs was significantly shorter in the Pabpn1l -/- MII oocytes than in the Pabpn1l +/+. These results suggest that PABPN1L is involved in BTG4-mediated maternal mRNA degradation, and may antagonize poly(A) tail shortening in oocytes independently of its involvement in maternal mRNA degradation. Thus, PABPN1L variants could be a genetic marker of female infertility.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.08.20.258830
- https://www.biorxiv.org/content/biorxiv/early/2020/08/20/2020.08.20.258830.full.pdf
- OA Status
- green
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3059464066
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3059464066Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.08.20.258830Digital Object Identifier
- Title
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Maternal factor PABPN1L is essential for maternal mRNA degradation during maternal-to-zygotic transitionWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-08-20Full publication date if available
- Authors
-
Ying Wang, Tianhao Feng, Xiaodan Shi, Siyu Liu, Zerui Wang, Xin Zhang, Jintao Zhang, Shuqin Zhao, Junqiang Zhang, Xiufeng Ling, Mingxi LiuList of authors in order
- Landing page
-
https://doi.org/10.1101/2020.08.20.258830Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2020/08/20/2020.08.20.258830.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/08/20/2020.08.20.258830.full.pdfDirect OA link when available
- Concepts
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Downregulation and upregulation, Zygote, Biology, Andrology, Messenger RNA, Oocyte, Embryo, Infertility, RNA, RNA splicing, Embryogenesis, Cell biology, Gene, Genetics, Pregnancy, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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48Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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