Mathematical models of developmental vascular remodelling: A review Article Swipe
Jessica R. Crawshaw
,
Jennifer A. Flegg
,
Miguel O. Bernabéu
,
James M. Osborne
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pcbi.1011130
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pcbi.1011130
Over the past 40 years, there has been a strong focus on the development of mathematical models of angiogenesis, while developmental remodelling has received little such attention from the mathematical community. Sprouting angiogenesis can be seen as a very crude way of laying out a primitive vessel network (the raw material), while remodelling (understood as pruning of redundant vessels, diameter control, and the establishment of vessel identity and hierarchy) is the key to turning that primitive network into a functional network. This multiscale problem is of prime importance in the development of a functional vasculature. In addition, defective remodelling (either during developmental remodelling or due to a reactivation of the remodelling programme caused by an injury) is associated with a significant number of diseases. In this review, we discuss existing mathematical models of developmental remodelling and explore the important contributions that these models have made to the field of vascular development. These mathematical models are effectively used to investigate and predict vascular development and are able to reproduce experimentally observable results. Moreover, these models provide a useful means of hypothesis generation and can explain the underlying mechanisms driving the observed structural and functional network development. However, developmental vascular remodelling is still a relatively new area in mathematical biology, and many biological questions remain unanswered. In this review, we present the existing modelling paradigms and define the key challenges for the field.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pcbi.1011130
- https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011130&type=printable
- OA Status
- gold
- Cited By
- 18
- References
- 132
- Related Works
- 10
- OpenAlex ID
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https://openalex.org/W4385520744Canonical identifier for this work in OpenAlex
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https://doi.org/10.1371/journal.pcbi.1011130Digital Object Identifier
- Title
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Mathematical models of developmental vascular remodelling: A reviewWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-08-03Full publication date if available
- Authors
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Jessica R. Crawshaw, Jennifer A. Flegg, Miguel O. Bernabéu, James M. OsborneList of authors in order
- Landing page
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https://doi.org/10.1371/journal.pcbi.1011130Publisher landing page
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https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011130&type=printableDirect link to full text PDF
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goldOpen access status per OpenAlex
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https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011130&type=printableDirect OA link when available
- Concepts
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Vascular remodelling in the embryo, Sprouting angiogenesis, Angiogenesis, Biology, Mathematical model, Neuroscience, Computer science, Hierarchy, Computational biology, Neovascularization, Mathematics, Statistics, Cancer research, Endocrinology, Economics, Market economyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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18Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 6, 2023: 4Per-year citation counts (last 5 years)
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132Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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