Matrix stiffness modulates androgen response genes and chromatin state in prostate cancer Article Swipe
Roosa Kaarijärvi
,
Heidi Kaljunen
,
Onni Niemi
,
Mikko Räsänen
,
Ville Paakinaho
,
Kirsi Ketola
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/narcan/zcaf010
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/narcan/zcaf010
The interplay between the extracellular matrix (ECM) and prostate cancer has been shown to increase ECM stiffness, correlating with more aggressive disease forms. However, the impact of ECM stiffness on the androgen receptor (AR), a key target in prostate cancer treatment, remains elusive. Here, we investigated whether matrix stiffness influences prostate cancer progression, transcriptional regulation, chromatin state, and AR function in AR-positive prostate cancer cells under varying ECM stiffness conditions. We utilized ATAC-seq (assay for transposase-accessible chromatin with sequencing) and RNA sequencing under different ECM conditions, along with the SUC2 metastatic prostate adenocarcinoma patient dataset, to investigate the role of ECM stiffness in chromatin state and androgen response genes, as well as its impact on prostate cancer progression. Results demonstrated that increased ECM stiffness elevated the expression of genes related to proliferation and differentiation. In contrast, androgen response genes were most highly induced in soft ECM conditions. Integrating chromatin accessibility with transcriptomic data revealed that androgen response genes were more transcriptionally available in soft ECM conditions. Additionally, increased ECM stiffness upregulated genes associated with low overall survival in the SUC2 dataset. Taken together, our results indicate that high expression of hard matrix stiffness genes may promote prostate cancer progression, leading to more aggressive disease forms associated with poor survival.
Related Topics
Concepts
Prostate cancer
Chromatin
Extracellular matrix
Cancer research
Prostate
Biology
Androgen receptor
Transcriptome
Chromoplexy
Cancer
Cell biology
Gene
Gene expression
PCA3
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/narcan/zcaf010
- OA Status
- gold
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408672008
All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W4408672008Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/narcan/zcaf010Digital Object Identifier
- Title
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Matrix stiffness modulates androgen response genes and chromatin state in prostate cancerWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-15Full publication date if available
- Authors
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Roosa Kaarijärvi, Heidi Kaljunen, Onni Niemi, Mikko Räsänen, Ville Paakinaho, Kirsi KetolaList of authors in order
- Landing page
-
https://doi.org/10.1093/narcan/zcaf010Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1093/narcan/zcaf010Direct OA link when available
- Concepts
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Prostate cancer, Chromatin, Extracellular matrix, Cancer research, Prostate, Biology, Androgen receptor, Transcriptome, Chromoplexy, Cancer, Cell biology, Gene, Gene expression, PCA3, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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42Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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