Mechanical activity enables patterning and discrimination at the immune synapse Article Swipe

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Tony E. Wong , Tom Chou , Suraj Shankar , Shenshen Wang ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.48550/arxiv.2510.18771

Immune cells recognize and discriminate antigens through immunological synapses - dynamic intercellular junctions exhibiting highly organized receptor-ligand patterns. While much work has focused on molecular kinetics and passive mechanisms of pattern formation, the role of active mechanical control in patterning and discrimination remains underexplored. We develop a minimal continuum model coupling receptor binding kinetics, membrane deformation, and cytoskeletal forces, with elastohydrodynamic flow in the synaptic cleft. Numerical simulations and scaling analysis reveal that contractile cortical flows arrest coarsening and stabilize long-lived multifocal clusters, whereas active pulling accelerates cluster dissolution and elevates background receptor binding. Nonequilibrium mechanical forces enable adaptive control over the speed, sensitivity, and dynamic range of affinity discrimination in a pattern-dependent manner. Our results highlight how immune cells exploit cytoskeletal remodeling to robustly regulate antigen recognition through synaptic patterning.

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Type: preprint
Landing Page: http://arxiv.org/abs/2510.18771
PDF: https://arxiv.org/pdf/2510.18771
OA Status: green
OpenAlex ID: https://openalex.org/W4416057153

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OpenAlex ID: https://openalex.org/W4416057153

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DOI: https://doi.org/10.48550/arxiv.2510.18771

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Title: Mechanical activity enables patterning and discrimination at the immune synapse

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Type: preprint

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Publication year: 2025

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Publication date: 2025-10-21

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Authors: Tony E. Wong, Tom Chou, Suraj Shankar, Shenshen Wang

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Landing page: https://arxiv.org/abs/2510.18771

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PDF URL: https://arxiv.org/pdf/2510.18771

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