arXiv (Cornell University)
Mechanical activity enables patterning and discrimination at the immune synapse
October 2025 • Tony E. Wong, Tom Chou, Suraj Shankar, Shenshen Wang
Immune cells recognize and discriminate antigens through immunological synapses - dynamic intercellular junctions exhibiting highly organized receptor-ligand patterns. While much work has focused on molecular kinetics and passive mechanisms of pattern formation, the role of active mechanical control in patterning and discrimination remains underexplored. We develop a minimal continuum model coupling receptor binding kinetics, membrane deformation, and cytoskeletal forces, with elastohydrodynamic flow in the synapt…